Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Title
Now showing items 1339-1358 of 1683
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Structure and dynamics of the aggregation mechanism of the Parkinson´s disease-associated protein alpha-synuclein
(2006-09-18)In Parkinson s disease (PD), intracellular neuronal inclusions containing amyloid-like aggregates of the protein alpha-synuclein (aS) are deposited in the pigmented nuclei of the brainstem. ... -
Structure and function of A.nidulans PSI factor producing oxygenase A
(2013-04-25)Phytopathogenic fungi are not only of economic importance for the yield depression they cause, but can also be considered as severe threat for the health of the consumer ingesting molded crops and fruits. This health threat ... -
Structure and function of microbial communities involved in biomineralization
(2022-01-27)Different aspects of carbonate precipitation are considered in this study. The first part examines carbonates in a model system that helps to explain the initial steps in the formation of so-called concretions, which are ... -
Structure and function of the membrane protein Opa60 by solid-state NMR
(2021-10-18)Studying the structure of transmembrane (TM) proteins is an important task since many of them are drug targets and are involved in essential cellular functions. However, new techniques are urgently needed, as TM proteins ... -
Structure Determination of Viscotoxin A1, Tendamistat and Tri Peptidyl peptidase-I
(2008-10-22)The current work reports the methods used to elucidate crystal structures of the target proteins using experimental phasing as well as their structure analysis.Viscotoxins belong to the ... -
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome and implications for chromatin remodelling
(2020-07-15)Eukaryotic cells condense their DNA into chromatin, which hampers the accessibility of genetic information. Nucleosomes are the smallest building blocks of chromatin and are comprised of an octameric core of histone proteins, ... -
Structure of the Pol II initation complex with TFIIH and core Mediator and mechanistic implications for transcription
(2018-03-13)The transcription of protein coding genes is a key step in the conversion of genomic information into the content of a cell’s proteome. In eukaryotes, this process is performed by the multi-subunit DNA-dependent RNA ... -
Structure-based Search for novel c-di-AMP Synthase Inhibiting Fragments
(2023-03-24)One of the major threats for the global health system is the increasing number of antibiotic resistant bacterial strains. The misuse of antibiotics during the Covid pandemic aggravates these problems. Therefore, the ... -
Structure-Function Analysis of the Cell Polarity Determinants Bud8p and Bud9p in <i>Saccharomyces cerevisiae</i>
(2007-05-22)Polarity is a fundamental cellular property of living organisms and a prerequisite for orientation and survival in a multidimensional environment. In the eukaryotic model organism Saccharomyces ... -
Struktur und Dynamik des Feinwurzelsystems von tropischen Bergwäldern in Abhängigkeit von der Meereshöhe in Südecuador
(2006-08-08)In a tropical montane rainforest in the South of Ecuador the effect of increasing altitude on structure and dynamics of fine root system was assessed. Fine root bio- and necromass, ... -
Struktur- und Funktionsanalysen des Pax4-Promotors
(2002-04-05)Pax4 is a member of the Pax family of transcription factors with restricted expression and essentia l functions in the developing pancreas. Pax4 deficient mice do not develop pancreatic ... -
Struktur-Funtionsbeziehung in den spleißosomalen Proteinen des U4/U6•U5 tri-snRNP
(2007-01-29)Subject of this thesis is the splicesosmal U5-particle. The functional relationship of the proteins is investigated by means of limited proteolysis and spectroscopy. Due to the splicesosome's ... -
Strukturelle Charakterisierung der C-terminalen Domäne des spleißosomalen DExD/H-Box Proteins hPrp22
(2008-02-26)Splicing of pre-mRNA is one of the most dynamic processes in eukaryotic cells. In addition to the U snRNAs, there is a multitude of proteins involved in the splicing cycle. Some of them are mobile factors; others are ... -
Strukturelle und funktionale Analyse der acetylierten kleinen GTPase Ran
(2015-03-19)The nucleus is the most prominent feature of every eukaryotic cell. Since the nucleus contains virtually all the genetic information it separates the transcription and translation. This separation requires a bidirectional ... -
Strukturelle und funktionelle Untersuchungen zum m3G-Cap-vermittelten Kernimport spleißosomaler U snRNPs durch Snurportin1
(2005-02-01)During snRNP biogenesis the snRNAs are exported into the cytoplasm, where the assembly with the common Sm proteins occurs and the 5´cap nucleotide is modified from an 7-methyl-guanosine ... -
Strukturelle Untersuchungen zum Velvet-Komplex aus Aspergillus nidulans
(2013-03-22)The regulation of secondary metabolism and development in Aspergillus nidulans are two linked processes. Their regulation is dependent on light. The molecular basis for this connection is a complex composed of the two ... -
Students’ Interests in Agriculture: The Impact of School Farms Regarding Fifth and Sixth Graders
(2015-02-24)The present way of intensive agricultural production is closely connected to central issues of sustainable development such as the loss of biodiversity and climate change. The corresponding importance of agriculture stands ... -
Studien zu den biochemischen und strukturellen Eigenschaften von Snapin und zu seiner Rolle in der neuronalen Exozytose
(2005-01-10)Snapin has been originally described by Ilardi et al., 1999 as a brain specific protein that interacts with SNAP-25, one of the central proteins in neuronal exocytosis. Biochemical data on ... -
Studien zur Expression und Lokalisation von P-Typ ATPasen aus Dunaliella bioculata
(2001-06-13)The informations on structural consistencies of P-typ pumps that determine the subcellular distribution are very scarce. By means of DBCA1 (a putative Ca2+-ATPase) and DBPMA1 (a putative ... -
Studien zur Pathogenese humaner Leukoenzephalopathien
(2009-09-17)Leukoencephalopathies present a group of inborn, mostly neurodegenerative diseases. The aim of this work was to investigate two of these leukoencephalopathies: the GJA12-associated ...