Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Title
Now showing items 1345-1364 of 1720
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Stimulus-secretion coupling in pancreatic β-cells of healthy and diabetic rats in tissue slice preparation
(2006-07-04)A primary event in the development of type 2 diabetes is a decrease in the capacity of pancreatic β-cells to secrete insulin in response to glucose stimulation. The Goto Kakizaki (GK) ... -
Stoichiometric Biology of the Synapse
(2013-05-07)Synaptic transmission at chemical synapses relies on the fusion of neurotransmitter-loaded vesicles with the plasma membrane of the pre-synaptic terminal (exocytosis). The synaptic vesicle material is then retrieved from ... -
Strategies of Sexual Reproduction in Aphids
(2002-11-08)Second copulas of Uroleucon cirsii (L.) are shorter on average than first copulas both for individual males and females. This suggests that male aphids are limited by sperm, on the one hand, ... -
Strengths and Difficulties Questionnaire (SDQ)
(2008-02-12)This study examines whether the German translation of the Strengths and Difficulties Questionnaire (SDQ) is a reliable and valid screening instrument and whether it is as effective a tool for clinical diagnostics and ... -
Stress Response SCF Ubiquitin Ligase F box Protein Fbx15 Controls Nuclear Co repressor Localization and Virulence of the Opportunistic Human Fungal Pathogen Aspergillus fumigatus
(2016-09-06)Aspergillus fumigatus is the most prevalent cause for pulmonary infections in immuno-compromised patients. Virulence factors are often linked to developmental control mechanisms, which are often identified in the closely ... -
Structural Analysis of a Transactivation Domain Cofactor Complex
(2005-07-29)Signal Transducers and Activators of Transcription (STAT) proteins were discovered as targets for interferon activation. These proteins are dormant in the cytoplasm until they are activated ... -
Structural Analysis of the 50S Ribosomal Stalk
(2007-06-27)Protein biosynthesis represents a dynamic process that takes place on the ribosome and is driven by translation factors. Some of these factors are GTP binding proteins. They possess a limited ... -
Structural and biochemical characterization of c-di-AMP synthesizing enzymes
(2020-06-11)One major concern of today’s life is the increase of antimicrobial resistance and the rising num-ber of multi drug resistant bacterial species. There is an urgent need of identifying new antibi-otic drug targets since ... -
Structural and biochemical characterization of diheme <i>c</i>-type cytochromes
(2008-12-04)Cytochromes are an abundant family of proteins incorporating heme as a prosthetic group and are involved in processes of electron conduction or redox reactions. Heme consists of an aromatic ... -
Structural and functional analysis of exportin-cargo recognition
(2010-11-19)All nucleocytoplasmic exchange proceeds through nuclear pore complexes, which constitute giant aqueous channels in the nuclear envelope. Most of this traffic is mediated by Ran-dependent ... -
Structural and functional analysis of yeast proteins involved in ER-to-Golgi transport: Sec24p family proteins and the GTPase activating protein Gyp5p
(2001-06-20)To maintain their intricate, internal structure of specialized compartments as well as meeting the necessity to react to changes of environmental conditions, eukaryotic cells have evolved ... -
Structural and functional characterization of proteins involved in the biogenesis of spliceosomal U snRNPs
(2009-09-11)One major hallmark of eucaryotic organisms is the subdivision of their cells into different, membrane enclosed compartments. In their central compartment, the nucleus, eucaryotes store their ... -
Structural and functional characterization of the autophagy proteins Atg5 and Atg16L1 and their interaction partners
(2011-05-26)Autophagy is a degradative pathway conserved in eukaryotes. During autophagy a portion of the cytoplasm is sequestered by a de novo forming isolation membrane resulting in the formation of ... -
Structural and functional characterization of TIM22 complex in the inner mitochondrial membarne
(2024-08-16)Mitochondria have gained significant attention in disease models due to their crucial role in cellular energy production and metabolic activity. Understanding how mitochondria maintain their function and interact with other ... -
Structural and functional studies on GTPases involved in eukaryal translation initiation
(2015-06-05)Translation, the process of mRNA-encoded protein biosynthesis, is one of the fundamental processes that are universally conserved in extant cellular life. In all its major stages, namely initiation, elongation, termination ... -
Structural and Funtional Studies on VitaminB1-Dependent Human and Bacterial Transketolases
(2012-08-24)Transketolases (TKs, EC 2.2.1.1) are ubiquitous enzymes in cellular carbohydrate metabolism that require the cofactor thiamin diphosphate for catalytic activity. TKs are involved in numerous metabolic pathways whereas the ... -
Structural basis of human mitochondrial RNA processing
(2024-12-16)Mitochondrial transcription produces polycistronic transcripts, in which ribosomal RNA (rRNA) and messenger RNA (mRNA) regions are interspersed with transfer RNA (tRNA) sequences. Endonucleolytic cleavages at the 5' and ... -
Structural characterization of alpha-synuclein aggregates seeded by patient material
(2019-12-12)Neurodegenerative diseases share a common underlying pathologic hallmark, the appearance of insoluble protein aggregates in diverse tissues of the nervous system. For many neurodegenerative diseases a common temporal and ... -
Structural characterization of autophagy related protein complexes
(2017-06-08)Autophagy is a conserved and highly regulated process in eukaryotic cells that plays an important role in maintaining cellular homeostasis. During macroautophagy a double membrane grows de novo that encloses cytoplasmic ... -
Structural characterization of human spliceosome activation by cryo-EM
(2022-01-27)Eukaryotic genes are transcribed as precursor mRNA (pre-mRNA), in which coding regions (exons) are interrupted by non-coding regions (introns). Introns are excised and exons are ligated together in a two-step process ...