Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Title
Now showing items 240-259 of 1668
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Characterization of the Phosphomimetic Mutant Y39E of a-Synuclein
(2024-08-06)α-Synuclein (aSyn) has long been identified as a key factor in the pathogenesis of Parkinson's Disease (PD), with familial mutations in the SNCA gene contributing to the aberrant aggregation of aSyn. Its aggregation results ... -
Characterizing the RanGAP1-RanBP2 complex in mitosis
(2009-03-18)The RanGAP1-RanBP2 complex represents a fascinating macromolecular assembly comprising at least two enzymatic activities. On one hand, it harbors the GTP hydrolysis activating function of ... -
Characterizing the SUMOylation of APC4 and the Function of APC4 Within Neurons
(2021-09-23)The Anaphase Promoting Complex (APC/C) is an E3 ubiquitin ligase that is involved in multiple molecular processes in eukaryotic cells. It is regulated by an intricate system of post-translational modifications that enables ... -
Charakterisierung der angeborenen Immunantwort in SIV-infizierten Rhesusaffen
(2010-01-28)Members of the APOBEC protein family of deaminases like A3G and A3F are components of the innate immunity capable to inhibit the replication of HIV in vitro. Their ability to influence viral ... -
Charakterisierung der bradyzoitspezifisch exprimierten P-Typ Plasmamembran ATPase TgPMA1 in <i>Toxoplasma</i> <i>gondii</i>
(2003-09-02)Toxoplasma gondii is an obligate intracellular parasite that causes persistent infections in a broad range of warm-blooded vertebrates, including humans. A stage differentiation ... -
Charakterisierung der Eaf 1-Funktion für die Biogenese der Aminopeptidase 1
(2008-11-10)In Saccharomyces cerevisiae the leucine exopeptidase aminopeptidase 1 (Ape1) is synthesized as a cytosolic precursor. After oligomerisation to a homododecameric complex the enzyme gets ... -
Charakterisierung der endosomalen Qb-SNAREs Vti1a und Vti1b
(2005-08-05)SNARE proteins play an important role as mediators of membrane fusion in the intracellular membrane transport. The goal of this thesis was to enlighten the mechanism of intracellular ... -
Charakterisierung der konservierten Domänen des Transkriptionsfaktors N.t.BZI-1
(2002-05-15)The conserved domains of the transcriptional regulator BZI-1 are defined by the homology to related transcriptionfactors. The specific function of different domains is mediated by the modular ... -
Charakterisierung der Nicotiana tabacum bZIP-Transkriptionsfactoren BZI-2, BZI-3 und BZI-4 als Heterodimerisierungspartner von BZI-1
(2004-06-14)Three bZIP-transcription factors, BZI-2, BZ-3 and BZI-4 were isolated, which heterodimerise with BZI-1. In contrast to BZI-1, these proteins show distinct expression patterns. BZI-2 is ... -
Charakterisierung der Proteinphosphatase 1E (PPM1E) - Lokalisierung und Trunkation in Gehirngewebe und Effekte auf neuronale Morphologie in primärer Neuronenkultur
(2010-11-26)Alzheimer s disease (AD) is a progressive neurodegenerative disorder, characterized by early deficits in learning and memory with eventual loss of higher cognitive functions. Although ... -
Charakterisierung der Sumoylierung von p35, dem Aktivator der Zyklin-abhängigen Kinase 5 (Cdk5), und der daraus resultierenden funktionellen Konsequenz
(2013-05-28)For the central nervous system development and neuron-specific functions, including neurite outgrowth as well as synaptic function and plasticity, cyclin-dependent kinase (Cdk) 5 has a central role. Cdk5 activity requires ... -
Charakterisierung des 5-HT<sub>3B</sub>-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus
(2012-01-24)5-HT3B is a subunit of the serotonin receptor type 3 (5-HT3), which is an ion channel of the cys-loop receptor family. The gene HTR3B encodes for 5-HT3B. The polymorphism ... -
Charakterisierung des Kerntransportsystems von Linker-Histonen
(2001-12-04)Histones are the major protein constituents of the eukaryotic chromatin. The lysine-rich H1 histones are located in the linker region of DNA between nucleosome cores. After their synthesis ... -
Charakterisierung des mRNA-Exportweges bei zellulärem Stress in Saccharomyces cerevisiae
(2016-11-15)In response to stress cells activate a prompt expression of stress-specific genes of which chaperones are essential in stabilizing and refolding proteins. In this situation stress-specific RNAs are selectively transcribed, ... -
Charakterisierung eines neuen ATP-binding-cassette Transporters aus der ABCA-Subfamilie
(2004-09-08)This thesis describes the identification and characterisation of the novel ATP-binding-cassette gene ABCA5 and its putative rat orthologue rAbca5.ABCA5 was isolated and cloned from the human ... -
Charakterisierung eines neuen Proteins, Mapl-1 und seine Rolle in der Regulation der Pax-6 Funktion.
(2002-01-22)Pax proteins comprise a family of highly conserved transcriptional regulators that hold essential roles during embryonic development and organogenesis. The structural motif common to all ... -
Charakterisierung eines Proteinkomplexes in Säugerzellen, der am Transport zwischen Membrankompartimenten beteiligt ist.
(2006-03-29)The intracellular trafficking allows dynamic flux of proteins and lipids between different compartments. This is largely mediated by the budding of vesicles from a donor compartment, followed ... -
Charakterisierung mukosaler Immunantworten im SIV-Makaken-Modell für AIDS
(2010-01-07)The massive damage of mucosal tissue as a consequence of infection as well as the sexual transmission of HIV via mucosa-associated tissue requires a better knowledge about these organs. The comparative flow-cytometric ... -
Charakterisierung Subtyp-spezifischer Autophagieproteine
(2009-06-15)Macroautophagy is a starvation-induced protein degradation pathway that nonselectively delivers cytosolic material and organelles to the vacuole (lysosome) for degradation. The Cvt-pathway ...