Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Title
Now showing items 260-279 of 1725
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Charakterisierung der Sumoylierung von p35, dem Aktivator der Zyklin-abhängigen Kinase 5 (Cdk5), und der daraus resultierenden funktionellen Konsequenz
(2013-05-28)For the central nervous system development and neuron-specific functions, including neurite outgrowth as well as synaptic function and plasticity, cyclin-dependent kinase (Cdk) 5 has a central role. Cdk5 activity requires ... -
Charakterisierung des 5-HT<sub>3B</sub>-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus
(2012-01-24)5-HT3B is a subunit of the serotonin receptor type 3 (5-HT3), which is an ion channel of the cys-loop receptor family. The gene HTR3B encodes for 5-HT3B. The polymorphism ... -
Charakterisierung des Kerntransportsystems von Linker-Histonen
(2001-12-04)Histones are the major protein constituents of the eukaryotic chromatin. The lysine-rich H1 histones are located in the linker region of DNA between nucleosome cores. After their synthesis ... -
Charakterisierung des mRNA-Exportweges bei zellulärem Stress in Saccharomyces cerevisiae
(2016-11-15)In response to stress cells activate a prompt expression of stress-specific genes of which chaperones are essential in stabilizing and refolding proteins. In this situation stress-specific RNAs are selectively transcribed, ... -
Charakterisierung eines neuen ATP-binding-cassette Transporters aus der ABCA-Subfamilie
(2004-09-08)This thesis describes the identification and characterisation of the novel ATP-binding-cassette gene ABCA5 and its putative rat orthologue rAbca5.ABCA5 was isolated and cloned from the human ... -
Charakterisierung eines neuen Proteins, Mapl-1 und seine Rolle in der Regulation der Pax-6 Funktion.
(2002-01-22)Pax proteins comprise a family of highly conserved transcriptional regulators that hold essential roles during embryonic development and organogenesis. The structural motif common to all ... -
Charakterisierung eines Proteinkomplexes in Säugerzellen, der am Transport zwischen Membrankompartimenten beteiligt ist.
(2006-03-29)The intracellular trafficking allows dynamic flux of proteins and lipids between different compartments. This is largely mediated by the budding of vesicles from a donor compartment, followed ... -
Charakterisierung mukosaler Immunantworten im SIV-Makaken-Modell für AIDS
(2010-01-07)The massive damage of mucosal tissue as a consequence of infection as well as the sexual transmission of HIV via mucosa-associated tissue requires a better knowledge about these organs. The comparative flow-cytometric ... -
Charakterisierung Subtyp-spezifischer Autophagieproteine
(2009-06-15)Macroautophagy is a starvation-induced protein degradation pathway that nonselectively delivers cytosolic material and organelles to the vacuole (lysosome) for degradation. The Cvt-pathway ... -
Charakterisierung und experimentelle Therapien eines neuen Mausmodells für das Rett Syndrom
(2015-11-20)Rett syndrome is one of the most frequent genetic causes of mental retardation of females. To date still no treatment exists for this disease, although genetic approaches in mice showed that Rett syndrome is treatable, at ... -
Charakterisierung und Kristallisation der Elektronen-einspeisenden Module der F<sub>420</sub>H<sub>2</sub>-Dehydrogenase
(2004-07-28)The F420H2: quinone oxidoreductase from the hyperthermophilic sulfate reducing archaeon Archaeoglobus fulgidus and the F420H2: phenazine oxidoreductase from the methanogenic ... -
Charakterisierung und Nutzung der mikrobiellen Diversität extremer Habitate der Kamtschatka-Region
(2009-01-06)The Kamchatka Peninsula, located in the northeast of Russia is known for its variety of volcanic areas. Samples from these environments are excellent sources for extremophilic microorganisms ... -
Charakterisierung von Calcium-Transienten in Astrozyten der ventralen respiratorischen Gruppe
(2007-11-27)Astrocytes are described as one of the major cell population in the brain of mammals and show a special form of excitability, which is based on changes of intracellular Ca2+-concentrations. ... -
Charakterisierung von einer retrograden Modulation inhibitorischer synaptischer Transmission im Kleinhirn der Ratte
(2003-12-15)In recent years, a lot of interest has been given to retrograde modulatory mechanisms of synaptic transmission: in many regions of the central nervous system, substances released from ... -
Charakterisierung von funktionellen Oberflächenstrukturen des Hepatitis-B-Virus Nukleokapsids
(2005-12-28)During hepatitis B virus (HBV) morphogenesis the transmembrane large envelope protein (L protein) probably directly interacts with mature cytosolic nucleocapsids. The shell of the capsid ... -
Charakterisierung von Leupaxin und seiner Interaktionspartner in Karzinomzellen
(2011-02-23)Leupaxin (LPXN) is identified as a protein enhancing the growth of existing TRAMP-tumours and metastasis. Various pathways give evidence of this effect. The overexpression of LPXN in Prostate ... -
Charakterisierung von lipid droplet-Regulatoren der Fruchtfliege <i>Drosophila melanogaster</i>
(2012-09-28)The storage of lipids as a reservoir for energy and biosynthetic building blocks is a central feature of life. At the same time, storage amounts need to be tightly controlled since a failed regulation severely impacts the ... -
Charakterisierung von Mikrogliafunktionen im Simianen Immundefizienzvirus (SIV) - Rhesusaffentiermodell für AIDS
(2009-01-23)Nearly 60% of patients infected with HIV are affected by neurological and psychiatric symptoms. The motor and cognitive dysfunctions, as well as behavioral changes are described by the term ... -
Charakterisierung von SNARE-Proteinen in der Hefe Saccharomyces cerevisiae
(2003-05-14)SNARE proteins are involved in the fusion of transport vesicles with target membranes in all eukaryotes and form complexes in which 3 Q-SNAREs interact with one R-SNARE. In the first part ...