Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Title
Now showing items 800-819 of 1652
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Investigation of the mitochondrial contact site and cristae organizing system and its role in cristae formation
(2020-10-27)Mitochondria are essential organelles in eukaryotic cells that feature a unique doublemembrane architecture. The mitochondrial inner membrane forms numerous invaginations, named cristae, which can adopt different shapes ... -
Investigation of the role of prolyl isomerase A in protein misfolding associated with neurodegenerative diseases
(2023-06-26)Misfolded proteins and disrupted homeostasis are key characteristics of neurodegenerative diseases. There is a strong association between intrinsically disordered proteins and pathogenic misfolding in neurodegenerative ... -
Investigation of the structure of spliceosomal complexes from the yeast S. cerevisiae
(2021-03-19)Nuclear pre-mRNA splicing is catalysed by the spliceosome, a multi-megadalton ribonucleoprotein (RNP) complex. It assembles de novo for each round of splicing on premRNA intron with stepwise binding of five small nuclear ... -
Investigation of TOMM20 Interactome in Relation to Protein Quality Control and Translocation
(2024-11-11)The human mitochondria are home to a vast repertoire of approximately 1,500 proteins, most of which are synthesized within the cytosol and post-translationally translocated into the mitochondria. Amidst the intricate ... -
Investigation on the molecular factors driving the formation of distinct tau 'strains'
(2022-11-28)Pathological aggregation of the microtubule-binding protein tau into amyloid fibrils is a hallmark of different neurodegenerative diseases collectively termed tauopathies. To date, tau amyloid structures associated with ... -
Investigation on the Physiological and Pathological Aspects of the Proline-Rich Region of the Microtubule-Associated Protein Tau
(2020-12-17)The microtubule-associated protein tau is involved in several neurodegenerative diseases including Alzheimer’s disease (AD), Pick’s disease (PiD), Progressive Supranuclear Palsy (PSP) and others. The aggregation and ... -
Investigations into the mode of action of the DNA uridine endonuclease Mth212 of Methanothermobacter thermautotrophicus ΔH
(2010-03-05)Spontaneous hydrolytic deamination of cytosine to uracil is one of the most frequent DNA modifications during cellular everyday metabolism. To counteract this mutagenic effect, most organisms ... -
Investigations into the regulation of histone H2B monoubiquitination
(2011-10-26)Transcription-associated chromatin modifications are recognized now as important regulators of gene expression. One of them, the monoubiquitination of lysine 120 of histone H2B (H2Bub1), ... -
Investigations of sirtuin metabolism
(2015-04-15)Sirtuins are a class of histone deacetylases (HDACs) found in all organisms in all three domains of life. Unlike other classes, which hydrolyze water, sirtuins require NAD+ as co-substrate and form nicotinamide and the ... -
Involvement of N-type voltage dependent calcium channels in axon degeneration during experimental autoimmune optic neuritis
(2007-11-27)Optic neuritis is one of the most common clinical manifestations of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS). After an episode of optic ... -
Involvement of the paired-domain transcription factor Pax6 in the regulation of glucagon gene transcription by insulin
(2000-11-23)Regulation of gene transcription is an important aspect of insulin's action. However, the mechanisms involved are poorly understood. Insulin inhibits glucagon gene transcription and insulin deficiency is associated ... -
Is increased Na+ influx a cause of mitochondrial redox stress, cardiomyopathy, and a therapeutic target?
(2023-11-09)Maintaining balanced Na+ levels is critical for normal functioning of cardiomyocytes, including contractions, excitation-contraction coupling (ECC), and metabolism. The NaV1.5-F1759A (human) mutation, which increases ... -
Isolation and characterisation of synaptic vesicles from mouse brain
(2011-08-08)All eukaryotic cells exhibit a constant turnover of membrane components via trafficking of vesicles between subcellular compartments. A classical example of a dynamic membrane delimited ... -
Isolation and Characterization of Human Precatalytic Spliceosomal B Complexes
(2007-04-26)The spliceosomal B complex is the substrate that undergoes catalytic activation leading to catalysis of pre-mRNA splicing. Previous characterization of this complex was performed in the ... -
Isolation and Characterization of Proteins Interacting with Tobacco Transcription Factor TGA2.2
(2004-07-09)In plants, the as-1 cis-element and its trans-acting factors, known as TGA transcription factors, play an important role in the transcriptional control of salicylic acid- and auxin-inducible ... -
Isolation and characterization of Saccharomyces cerevisiae mutants for vacuolar import and autophagocytosis
(2001-11-01)The yeast vacuolar protein aminopeptidase 1 (Apelp) is synthesised as a cytosolic procursor that is transported to the vacuole via the cytoplasm to vacuole trnasport (Cvt) pathway. The ... -
Isolation and characterization of tissue and development-specific microRNAs from Drosophila, mouse and human
(2005-07-19)MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression in plants, animals and viruses. These small RNAs provide specificity to protein effector complexes mediating ... -
Isolation and functional analysis of differentially expressed genes in human prostate cancer
(2003-02-27)Prostate cancer is the most frequently diagnosed solid tumor in men, and the second leading cause of cancer death in males from western countries. One of the key issues in prostate cancer ... -
Die Isolierung und Charakterisierung der cDNA und des Gens Metr-1 der Maus, einem Vertreter der Bruno-like Genfamilie und Analysen zur Expression
(2002-12-13)The BRUNO-like proteins are family members of the RNA Binding proteins. These proteins play an important role in development, cell differentiation and regulation of the nervous system, ... -
Isolierung und Charakterisierung der gamma-Tocopherolmeth yltransferase
(2001-12-18)The tocopherols and tocotrienols are well known antioxidants and play an important role in protecting cells from free radical damage and in the prevention of many diseases, e.g. cancer and ...