Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Title
Now showing items 972-991 of 1708
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Molecular and Functional Characterization of Programmed Cell Death (PCD) in Toxoplasma gondii
(2013-05-06)Toxoplasma gondii is a protozoan parasite which leads to widespread infections in humans and animals worldwide. Infection is typically asymptomatic in immunocompetent hosts, but may lead to severe symptoms in immunocompromized ... -
Molecular and structural investigation of assembly, maturation and heterogeneity of inner hair cell ribbon synapses
(2019-10-07)Age-related hearing and balance impairments represent the most common sensory deficits in humans. Both senses rely on hair cell ribbon synapses, which are highly specialized to sustain continuous release of neurotransmitter ... -
Molecular Characterization of pFGE, the Paralog of the C-α-Formylglycine-generating Enzyme
(2006-03-01)C-α formylglycine (FGly) is the catalytic residue in the active site of sulfatases. In eukaryotes, it is generated in the endoplasmic reticulum by post-translational modification of a ... -
Molecular Characterization of the Male Germ Cell Expressed Genes Hook1 and TSEP22
(2003-12-10)In this work, the two murine genes Hook1 and TSEP22 were characterized at the molecular level. Both genes were expressed in male germ cells and the presence of the gene products of these ... -
Molecular Dynamics Studies of the Phi29 Connector-DNA complex
(2015-04-10)During replication of the Phi29 bacteriophage, a DNA packaging motor packages the viral DNA into the procapsid against a maximum pressure difference of ~60 atm, which is generated by the already packed DNA. Several models ... -
Molecular evidence for the antiquity of group I introns inter-rupting transfer RNA genes in cyanobacteria
(2003-05-14)Genes interrupted by group I introns have been the perennial focus of evolutionary studies. Previous work has demonstrated the importance of lateral transfer in the evolutionary history of these auto-catalytic molecules. ... -
Molecular Evolution in non-bilaterian Metazoa with Emphasis on Phylum Porifera
(2010-01-21)The relationships between and within non-bilaterian phyla (Porifera, Placozoa, Cnidaria and Ctenophora) at the base of the metazoan tree of life are not resolved and still much debated. One ... -
Molecular evolution of primates - featuring mobile elements
(2009-03-12)With at least 66 genera and about 350 species, the order Primates is one of the most diverse mammalian orders. Even though the phylogenetic relationships among major lineages are elucidated, ... -
Molecular mechanism of Inhibition of the CREB-coactivator TORC by the mitogen-activated kinase DLK in pancreatic beta-cells
(2010-09-08)The ubiquitously expressed transcription factor CREB is involved in numerous cell signalling pathways including metabolic process, cell cycle or survival, cell growth and immune ... -
Molecular mechanisms governing germ line development in zebrafish and the role of this lineage in sexual differentiation
(2006-03-17)Primordial germ cells (PGCs) in zebrafish are specified early in the development by inheritance of a specific type of cytoplasm termed germ plasm. The asymmetrically distributed germ plasm ... -
Molecular Mechanisms in Primordial Germ Cell Development in Zebrafish
(2007-10-16)In many organisms, primordial germ cells (PGCs) are specified early on in development at distant places from where the gonad will develop. Therefore, the cells have to migrate to reach the ... -
Molecular mechanisms of acute axonal degeneration in the rat optic nerve
(2015-12-03)The development of neuroprotective treatments is urgently needed for neurodegenerative and neurotraumatic diseases. As axonal degeneration is a key initiating event in these diseases, it is pivotal to better understand and ... -
Molecular Mechanisms of Frequency Discrimination in the Drosophila Ear
(2023-01-24)Since the first confirmed evidence of potassium ions crossing the membrane to the first cloned and identified potassium channel from Drosophila melanogaster, the studies of potassium channels have extensively broadened our ... -
Molecular mechanisms of myelin membrane biogenesis
(2008-03-26)During vertebrate brain development, axons are ensheathed by myelin, an insulating membrane generated by oligodendrocytes. Our aim is to elucidate the cellular machinery that is required for the formation of this membrane. ... -
Molecular mechanisms of replication stress-induced mitotic chromosome missegregation
(2022-12-09)Chromosomal instability (CIN), the process of the generation of structural and numerical changes in the karyotype, is a major hallmark of human cancer generating genetic variation, thereby driving tumor evolution and ... -
Molecular Mechanisms of Serotonergic Signaling: Role in Neuronal Outgrowth and Receptor Oligomerization
(2010-12-21)Role of 5-HT7/G12 signaling in morpho- and synaptogenesis. The neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) modulates different aspects of early neuronal differentiation, including ... -
Molecular mechanisms of the cytokine-dependent induction of the heme oxygenase-1 gene: in vivo and in vitro studies
(2004-09-27)Heme oxygenase 1 (HO-1) is the inducible enzyme which catalyzes the rate-limiting reaction of heme degradation yielding carbon monoxide (CO), divalent iron (Fe2+), and biliverdin. Due to a ... -
Molecular mechanisms underlying cortical (mal)formation: case studies of ESCO2 and EXOSC10
(2021-09-23)This work focuses on elucidating the molecular mechanisms that control the cortical development. Identification of genes and factors that direct the development of the cerebral cortex will both tell us about their ... -
Molecular mechanisms underlying silent synapse generation and their role in drug-associated behaviors
(2025-08-29)Silent synapses are immature glutamatergic connections that express stable NMDARs, while AMPARs are absent. These synapses are abundant during early development and serve as plasticity substrates, offering synaptic ... -
Molecular motions at the 5 stem-loop of U4 snRNA: Implications for U4/U6 snRNP assembly
(2005-07-05)The human 15.5K protein binds to the 5' stem-loop of U4 snRNA (KtU4), promotes the assembly of the spliceosomal U4/U6 snRNP, and is required for the recruitment of the 61K protein and ...