Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Issue Date
Now showing items 41-60 of 1597
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Characterization of proneural bHLH transcription factor target genes in X. laevis
(2022-09-23)Zc3h12c is a member of the Zc3h12 endoribonuclease family (also known as MCPIP/Regnase), which contains four members (Zc3h12a-c). This family of proteins is characterized by the presence of a single centrally located ... -
The role of causal representations in moral judgment
(2022-09-05)Morality and causation are deeply intertwined. For instance, the value of anticipated consequences is a crucial input for an action’s moral permissibility, and assigning blame or responsibility for outcomes generally ... -
The Moral Permissibility of Killing in War: An Experimental Approach to the Moral Judgment of Side-Effect and Defensive Killing
(2022-09-05)In wars combatants face situations that challenge their moral compass. They may, for example, have to decide whether to pursue military victories to protect their community at the cost of harming innocents. They must also ... -
Cell type specific transcriptomic characterization of myelin abnormalities
(2022-08-22)Myelin is indispensable for the fast and efficient transmission of electric signals along axons. The formation of myelin by oligodendrocytes in the central nervous system (CNS) is tightly regulated at the transcriptional ... -
Investigating chemical crosslinking of protein-RNA complexes by mass spectrometry
(2022-08-12)RNA plays a quintessential role in cellular processes such as gene expression, transcription, RNA processing, and translation. Proteins carrying out those diverse functions are inherently flexible to accommodate dynamic ... -
HORMA domain proteins in Autophagy initiation
(2022-08-01)The autophagic pathway is an evolutionarily conserved strategy among eukaryotic cells for maintaining cell homeostasis at the basal level and during stressful conditions. It removes protein aggregates, damaged organelles, ... -
Biochemical characterization of human shieldin complex
(2022-08-01)Shieldin is a newly identified DNA repair effector involved in repair of double strand breaks (DSBs) in G1 phase of cell cycle. Shieldin is a four-component complex consisting of proteins SHLD1, SHLD2, SHLD3 and HORMA REV7. ... -
Bioinformatic analysis of multi-omics data elucidates transcriptional cyclin dependent kinase mediated transcriptional regulation
(2022-08-01)Transcriptional regulation is a highly dynamic biological process which is governed by a complex network of proteins for precise expression of a gene. One of the most important regulators of gene expression are cyclin ... -
Untersuchungen zur Rolle von Mph1 aus Saccharomyces cerevisiae und seines menschlichen Orthologen FANCM bei der Erhaltung der genomischen Integrität
(2022-07-22)Living is life-threatening. Cells can only endure the diverse exogenous and endogenous attacks on their genome because they are equipped with a network of coordinated security measures: the DNA damage response. Repair ... -
Entwicklung eines soziotechnischen Gestaltungsmodells für die Arbeit mit Kollaborationsplattformen
(2022-07-19)This dissertation examines the introduction and use of collaboration platforms in companies. Thus, this thesis is a research contribution to the topic of digitization of work. An investigation of collaboration platform use ... -
Improving electron microscopic hardware to push the resolution limits in single particle cryo-EM
(2022-07-19)Electron cryomicroscopy (cryo-EM) is a powerful tool in structural biology for determining 3D structures of macromolecular complexes. In the previous decade, many technological advancements have been introduced to improve ... -
Nucleo-cytoplasmic shuttling of snoRNAs in Saccharomyces cerevisiae
(2022-07-19)Small nucleolar RNAs (snoRNAs) are a group of small non-coding RNAs involved in the post-transcriptional modification of RNAs, such as rRNA and tRNA. The importance of their role is evidenced by the rRNA regions subject ... -
Understanding Transcriptional Control During Primordial Germ Cell Differentiation
(2022-07-08)AP2γ, encoded by Tfap2c, is a transcription factor which both represses and activates target gene expression. It is required for the survival of the early mouse embryo; depending on the context of its depletion, the loss ... -
Biophysical characterization and computational modeling of phase separation of immune adapter proteins
(2022-07-07)The processes of B cell activation and development are stimulated by antigen binding to the B cell receptor. Pre-signaling clusters are present in unstimulated, resting B cells and assemble by tripartite phase separation ... -
Functional imaging of the anesthetized brain in primates and rodents
(2022-07-05)Understanding the brain is aided by visualizing neural activity over time. The most popular method for doing so in humans is functional magnetic resonance imaging (fMRI)—a method that tracks blood oxygenation as a proxy ... -
A healthy social life? Sociality and health indicators in wild red-fronted lemurs
(2022-06-29)In the last 40 years, an increasing number of studies from medicine, neurosciences, and psychology demonstrated links between many aspects of sociality, health, and fitness in humans and laboratory animals. Some studies ... -
Characterization and development of bacteriophytochrome-derived near-infrared fluorescent proteins for the application in super-resolution microscopy
(2022-06-29)The developments of fluorescence microscopy techniques has advanced our understanding of biological systems on a cellular level. In recent years, several super-resolution microscopy techniques overcame the diffraction ... -
Vitality of heather (Calluna vulgaris) along gradients of climate, structure and diversity in dry lowland heathland habitats of Northern Germany
(2022-06-29)This thesis provides a fundamental overview to North German Dry lowland heathland vegetation composition, vegetation structures and the determinants for the vitality of the key species, Calluna vulgaris. It offers new ... -
Biodiversity Governance: Non-State and Sub-National Initiatives in Latin America
(2022-06-21)Non-state and sub-national actors have been increasingly taking action to address biodiversity loss, however, only relatively recently their initiatives started being integrated into international biodiversity governance. ... -
Decision-Making During Ongoing Actions
(2022-06-21)Contemporary theories of action-based decision-making suggest that making decisions between goods, and specifying the actions required to obtain these goods, are parallel and intertwined processes, which allows for highly ...