Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor & Referee "Bähr, Mathias Prof. Dr."
Now showing items 1-5 of 5
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Modulation of the ROCK pathway in models of Parkinson´s disease
(2015-12-09)The cure of neurodegenerative diseases is one of the main goals in today’s neuroscience research. One of the main obstacles is the delayed diagnostics in relation to molecular pathology. In Parkinson’s disease (PD), several ... -
Charakterisierung der Sumoylierung von p35, dem Aktivator der Zyklin-abhängigen Kinase 5 (Cdk5), und der daraus resultierenden funktionellen Konsequenz
(2013-05-28)For the central nervous system development and neuron-specific functions, including neurite outgrowth as well as synaptic function and plasticity, cyclin-dependent kinase (Cdk) 5 has a central role. Cdk5 activity requires ... -
Prion protein-induced proteome alterations in sporadic Creutzfeldt-Jakob disease and in SH-SY5Y cell culture model
(2011-01-11)Cellular prion protein (PrPC) is a glycosylated membrane glycoprotein mainly expressed in the central nervous system. Some still undefined molecular events can lead to the conversion of ... -
Überleben und Differenzierung TAT-Bcl-xL-transduzierter transplantierter neuraler Vorläuferzellen nach zerebraler Ischämie der Maus
(2010-01-06)Increased endogenous neurogenesis can be observed after cerebral ischemia in mice, but fails to significantly contribute to neural regeneration or integration. Therefore, the local application ... -
Development of Viral Tools for CNS Gene Transfer: Adeno-Associated Viral Vectors in Gene Therapy of Parkinson's Disease
(2006-08-09)Gene transfer to the brain is a promising therapeutic strategy for a variety of neurodegenerative disorders including Parkinson s disease (PD). PD is characterized by a progressive degeneration of the nigrostriatal ...