Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor & Referee "Figura, Kurt von Prof. Dr. Dr. h.c."
Now showing items 1-20 of 36
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Congenital Disorders of Glycosylation IIj (CDG-IIj): Identifizierung eines Defekts der COG6-Untereinheit des Conserved Oligomeric Golgi-Komplexes
(2010-09-16)`Congenital Disorders of Glycosylation` (CDG) are a rapidly expanding group of so far 23 autosomal recessive multisystemic disorders associated with deficiencies in the biosynthesis of ... -
Proteomanalyse lysosomaler Membranen: Identifizierung und Charakterisierung neuer lysosomaler Membranproteine
(2009-06-18)Lysosomes are intracellullar acidic vesicles, which contain a variety of soluble and membrane-bound proteins like hydrolases and transport-systems. They are found in all nucleated ... -
Charakterisierung Subtyp-spezifischer Autophagieproteine
(2009-06-15)Macroautophagy is a starvation-induced protein degradation pathway that nonselectively delivers cytosolic material and organelles to the vacuole (lysosome) for degradation. The Cvt-pathway ... -
Etablierung und Analyse von 'knock-out' Mausmodellen der σ1 Untereinheiten des AP 1 Komplexes
(2009-02-10)The multimeric adaptor protein complex 1 (AP-1) is essential for clathrin coated vesicle assembley mediating protein sorting between the trans-Golgi network (TGN) and the endosomal compartment. ... -
Charakterisierung der Eaf 1-Funktion für die Biogenese der Aminopeptidase 1
(2008-11-10)In Saccharomyces cerevisiae the leucine exopeptidase aminopeptidase 1 (Ape1) is synthesized as a cytosolic precursor. After oligomerisation to a homododecameric complex the enzyme gets ... -
Identifizierung und molekulare Charakterisierung des lysosomalen Matrixproteins Serincarboxypeptidase 1
(2008-07-30)The lysosomal matrix contains more than 50 hydrolytic enzymes that function in the degradation of macromolecules like polysaccharides, proteins, nucleic acids and lipids. Apart from their ... -
Signalbindung und Membraninteraktion von heterotetrameren Adaptorprotein-Komplexen
(2007-10-09)The heterotetrameric adaptor protein complexes AP1, AP2, AP3 and AP4 are involved in intracellular sorting of transmembrane proteins. APs interact with sorting signals of transmembrane ... -
Regulation des mitochondrialen Zerfalls innerhalb der neuronalen Apoptose
(2007-05-23)Under physiological conditions, mitochondrial morphology dynamically shifts between a punctuate appearance and tubular networks by fission and fusion events. Mitochondrial apoptosis pathways ... -
Ein Knockout-Mausmodell für Congenital Disorder of Glycosylation-IIc: Defizienz des Golgi-GDP-Fucose-Transporters
(2007-02-12)The monogenetic inherited human diseases termed 'Congenital Disorders of Glycosylation' (CDG) are caused by defects of enzymes and transporters involved in the modification of proteins by ... -
A novel pathway for VLDL assembly in the mouse liver
(2006-12-11)LDL is thought to be endocytosed and completely degraded by peripheral cells and the liver. Using primary mouse hepatocytes, mouse liver perfusion and intravenous LDL-injection in mice, it ... -
Identifikation und immunologische Charakterisierung von MHC-Klasse-II-Peptidepitopen in humanen Leukämie- und Lymphom-assoziierten Antigenen
(2006-11-27)CD4+ T cells play important roles in antitumor responses through several different mechanisms. Ultimately, they provide crucial help in the induction and maintenance of CTL responses. ... -
Efficacy of enzyme replacement therapy in α-manosidosis mice
(2006-08-11)The Lysosomal Storage Disorders (LSD) are a group of about 50 diseases caused by genetic defects that affect one or more of the lysosomal hydrolases. The defect results in the accumulation ... -
Molecular Characterization of pFGE, the Paralog of the C-α-Formylglycine-generating Enzyme
(2006-03-01)C-α formylglycine (FGly) is the catalytic residue in the active site of sulfatases. In eukaryotes, it is generated in the endoplasmic reticulum by post-translational modification of a ... -
Characterisation of the Early Endosomal SNARE Complex
(2005-11-23)SNARE proteins are crucial factors in membrane fusion. These membrane proteins assemble to four-helix coiled-coils consisting of four SNARE helices: Qa, Qb, Qc and R, thereby fusing opposing ... -
Recognition of basic sorting motifs within synaptic membrane cargo proteins by the clathrin-adaptor complex AP-2
(2005-08-24)Communication in the central nervous system (CNS) occurs via chemical synapses, intercellular asymmetric junctions between an axon and the dendrite of a neighbouring neuron. Synapses comprised ... -
Charakterisierung der endosomalen Qb-SNAREs Vti1a und Vti1b
(2005-08-05)SNARE proteins play an important role as mediators of membrane fusion in the intracellular membrane transport. The goal of this thesis was to enlighten the mechanism of intracellular ... -
Genetic analysis of stoned B/stonin 2 function in vivo
(2005-07-04)Clathrin-mediated endocytosis at presynaptic nerve terminals is a regulated process tightly coupled to the exocytotic fusion event that requires clathrin, dynamin, AP2 as well as synaptotagmin ... -
σ1-adaptin - the Small Subunit of the Clathrin Adaptor Complex AP-1
(2005-06-03)The adaptor protein AP-1 is a heterotetrameric complex which mediates the formation of clathrin-coated vesicles at the trans-Golgi network and at endosomes. The interactions with ... -
Identification of a new factor essential for vacuolar aminopeptidase I activity.
(2004-12-08)The Saccharomyces cerevisiae vacuolar aminopeptidase I, Ape1p, is transported from the cytoplasm to the vacuole by constitutive autophagocytosis. Ape1p is synthesized as a proform with a ... -
TIP47 is recruited to lipid droplets and important for the organelle biogenesis and function
(2004-09-27)The cytoplasmic protein TIP47 (tail interacting protein of 47kD) was characterized as a cargo selection device for MPRs (mannose 6-phosphate receptors) and supposed to determine MPR transport ...