Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor & Referee "Papantonis, Argyris Prof. Dr."
Now showing items 1-12 of 12
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Generation and characterization of an otic bioengineered neuronal organoid (oBENO) from human pluripotent stem cells
(2025-12-03)Hearing loss impacts nearly 20% of the global population, and according to estimations its prevalence will increase by 2050, affecting around 1 in 4 individuals. The most common form of hearing impairment, sensorineural ... -
Computational analysis of nucleosome assembly and cis-regulatory DNA elements
(2025-11-12)Induced pluripotent stem cells (iPSCs) represent embryonic stem cells (ESCs) that are reprogrammed from somatic stem cells. iPSCs can be directed to differentiate into any cell type in the human body, therefore, holding ... -
Analysis of Transcription Factor Binding and Cancer Stage-Specific Regulatory Dynamics Using DNA-Binding Domain Annotations
(2025-07-31)Transcription Factors (TFs) regulate gene expression by binding to specific DNA sequences through their DNA-Binding Domain (DBD)s. Accurate modeling of TF–DNA interactions is essential for uncovering the mechanisms of ... -
HMGB2 programming and structural variations as tumor supportive mechanisms in cancer
(2025-06-17)Cancer is a widespread disease that affects many. In order to escape into malignancy, a cell has to undergo a multistep process during which it acquires a set of traits. These traits allow it to replicate indefinitely and ... -
The role of chromatin hubs in the regulation of gene expression and maintenance of genomic integrity
(2025-03-20)The correct development and functioning of complex organisms rely on precise spatiotemporal regulation of gene expression and on efficient maintenance of their genomic stability. Regulation of gene expression during ... -
Coordinated Transcriptional Response to Stress-Related Disorders in Multiple Brain Regions: A Spatial and snRNA-sequencing Study in Mice
(2024-10-22)Recent work has demonstrated specific, genome-wide transcriptional changes related to fear and anxiety in rodent animal models and post-mortem human brain samples on the level of individual brain regions and even cell ... -
High-resolution analysis of regulatory interactions and nano-scale chromatin structures
(2024-09-11)Despite having the same genetic blueprint, the development of a complex, multicellular organism from a single fertilized egg results in a wide variety of hundreds distinct cell types, each uniquely contributing to the ... -
Investigation into gene regulatory networks governing the development and maintenance of the planarian reproductive system
(2024-03-20)Regulation of gene expression is a fundamental mechanism allowing the existence of complex living systems. This regulation takes shape in the form of hierarchical gene regulatory networks (GRNs), culminating in the binding ... -
Computational analysis of transcriptional regulation and chromatin assembly
(2023-12-07)Primordial germ cells (PGCs), the precursors of gametes, are specified from post-implantation epiblast cells in response to bone morphogenetic protein (BMP) signaling at the onset of gastrulation in mouse. Followed by ... -
Understanding the role of the transcription factor MGA in primordial germ cell differentiation
(2023-06-20)One of the most crucial cell lineage decisions in mammalian embryos is the differentiation of a few pluripotent epiblast cells into primordial germ cells (PGCs). PGCs are unique for their ability to mature into either sperm ... -
Genotype-Phenotype Correlation in Noonan Syndrome – Focus on LZTR1 and its Substrates
(2023-05-30)Noonan syndrome (NS) is a multisystemic disorder that is known as one of the most common monogenetic diseases associated with early-onset congenital heart defects, such as hypertrophic cardiomyopathy (HCM). Infants diagnosed ... -
Exploring the roles of RNAPII in genome organization
(2022-12-16)The role of RNAPII in 3D genome organization has been heavily debated over the last two decades. Here, in situ Hi-C and Micro-C data were used to conclusively address this debate. I discovered that: 1) using cell population ...