Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor & Referee "Posnien, Nico Dr."
Now showing items 1-8 of 8
-
Investigations towards a link of morphodynamics and transcriptional pattern in embryonic tissues during morphogenesis
(2025-09-16)The acquisition and loss of epithelial characteristics—such as apico-basal polarity, cell–cell adhesion, and barrier integrity—are essential processes during development, regeneration, and disease. While epithelial–mesenchymal ... -
Coordinated Transcriptional Response to Stress-Related Disorders in Multiple Brain Regions: A Spatial and snRNA-sequencing Study in Mice
(2024-10-22)Recent work has demonstrated specific, genome-wide transcriptional changes related to fear and anxiety in rodent animal models and post-mortem human brain samples on the level of individual brain regions and even cell ... -
Investigation into gene regulatory networks governing the development and maintenance of the planarian reproductive system
(2024-03-20)Regulation of gene expression is a fundamental mechanism allowing the existence of complex living systems. This regulation takes shape in the form of hierarchical gene regulatory networks (GRNs), culminating in the binding ... -
Computational analysis of transcriptional regulation and chromatin assembly
(2023-12-07)Primordial germ cells (PGCs), the precursors of gametes, are specified from post-implantation epiblast cells in response to bone morphogenetic protein (BMP) signaling at the onset of gastrulation in mouse. Followed by ... -
Ablation of cell-specific cholesterol synthesis affects cerebral β-amyloidosis
(2023-03-13)Cholesterol, an essential membrane component, among others modifies membrane fluidity and regulates cell signaling. CNS cholesterol metabolism is separated from peripheral cholesterol by specific properties of the ... -
Robust phylogenomic inference through genome skimming as demonstrated by a systematic analysis of Nereididae
(2022-12-16)The introduction of massively parallel sequencing in the mid-2000s has truly revolutionized the field of molecular phylogenetics and ultimately our understanding of the tree of life. Despite today's existence of long-read ... -
Functional characterization and molecular identification of neuroprotective receptors for erythropoietin-like ligands
(2019-12-19)The cytokine erythropoietin (Epo) regulates erythropoiesis but also protects mammalian neurons from apoptosis. However, receptors and transduction pathways involved in neuroprotection are only partially characterized. ... -
Comparative gene expression to study the developmental basis of organ diversification.
(2019-09-30)The striking diversity in adult morphologies is the result of millions of years of adaptation of species to different environments and habitats. Fixed changes in populations or species are the consequence of mutations in ...