Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor & Referee "Werner, Hauke Dr."
Now showing items 1-7 of 7
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CNS myelin heterogeneity in species, single myelin sheaths and in Multiple Sclerosis
(2025-06-16)In the Central Nervous System (CNS), oligodendrocytes (OLGs) produce myelin which is a specialized plasma membrane that supports axons. Similarly, Schwann Cells (SCs) fulfill this role in the Peripheral Nervous System ... -
Role of clathrin-mediated endocytosis in myelinating oligodendrocytes
(2024-05-17)The myelin sheath is a multi-layered oligodendroglial membrane that enwraps axons, providing insulation and support. Although myelin is one of the most long-lived structures in the nervous system, its maintenance requires ... -
CMTM5 - a novel CNS myelin protein involved in preserving axonal integrity
(2022-04-28)Myelination of axons in the nervous system facilitates rapid, saltatory signal propagation, accelerating nerve conduction speed manyfold. Additionally, myelinating glia support the long-term integrity of axons they ... -
Schwann cells restrict axonal diameters via CMTM6
(2021-05-03)Myelination of axons accelerates nerve impulse propagation 20-100-fold, theoretically allowing rapid nerve conduction with reduced axonal diameters. However, to our knowledge no myelin dependent signal has been described ... -
Functional characterization and molecular identification of neuroprotective receptors for erythropoietin-like ligands
(2019-12-19)The cytokine erythropoietin (Epo) regulates erythropoiesis but also protects mammalian neurons from apoptosis. However, receptors and transduction pathways involved in neuroprotection are only partially characterized. ... -
Oligodendroglial anillin facilitates septin assembly to prevent myelin outfoldings
(2019-02-25)Myelination of axons facilitates rapid and precise impulse propagation in the nervous system and thus, normal motor, sensory, and cognitive capabilities. In the central nervous system (CNS), myelin is formed by oligodendrocytes, ... -
Amyloid-beta driven changes in transcriptome plasticity: From OMICS to Therapy
(2016-04-06)Alzheimer’s disease is characterized by a progressive cognitive decline coinciding with the formation of amyloid plaques and tau fibrils in the human brain. It is the most common form of dementia and the number of people ...