Blättern Fakultät für Biologie und Psychologie (inkl. GAUSS) nach "Braus, Gerhard Prof. Dr." Betreuer
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Alterations in gene expression and secondary metabolite production during development of Aspergillus nidulans
(2014-02-10)Many studies describing development and secondary metabolism of the filamentous fungus Aspergillus nidulans contributed to a better understanding of fungal secondary metabolism regulation at the molecular level. However, ... -
Amino Acid Biosynthesis and the COP9 Signalosome in Aspergillus nidulans
(2003-01-30)The filamentous fungus Aspergillus nidulans represents an eukaryotic model system versatile in metabolism and developmental properties. This work focuses on the impact of modified enzyme ... -
Analysis of Neuronal Diseases in the Model Organism <i>Aspergillus nidulans</i>
(2008-12-11)Neuronal diseases can include abnormal aggregation of key proteins or the dysfunction of transport processes during the development of nerve cells. Parkinson s disease (PD) is a neurodegenerative ... -
Biosynthesis of Aromatic Amino Acids in Yeast and Aspergillus
(2001-02-22)Chorismate mutases (E.C. 5.4.99.5) catalyse the Claisen rearrangement of chorismic acid to prephenate, the first reaction of the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis. Within this ... -
Blue light-dependent development of the filamentous fungus Aspergillus nidulans
(2007-11-22)Numerous studies have revealed that fungal development and the production of secondary metabolites are linked although the molecular mechanisms are yet unknown. Light seems to be one of the ... -
C-terminal tyrosine residue modifications modulate α-synuclein toxicity in yeast as unicellular model for Parkinson´s disease
(2016-12-07)The presence of protein inclusions called Lewy bodies (LBs) that are mainly composed of misfolded and accumulated α-synuclein (αSyn) represents a hallmark of Parkinson´s disease (PD). Oligomeric αSyn species are thought ... -
Characterization of the pathogenicity relevant genes THI4 and PA14_2 in Verticillium dahliae
(2014-02-17)Verticillium is a soil-borne plant pathogen including species that are distributed all over the word. Up to now no fungicides could avoid an infection on host plants. In resting structures, (microscrlerotia, melanized ... -
Chromatinstruktur und Regulation der Genexpression am Histidin/Adenin-Verzweigungspunkt in Hefe und Aspergillus
(2001-10-23)Imidazole glycerole phosphate (IGP) synthase (E.C.2.4.2. & E.C.4.3.2.4) catalyzes the fifth and the sixth reaction step of the histidine biosynthesis. The byproduct of the reactions, AICAR, ... -
CsnA Dependent Development and Regulation of Amino Acid Biosynthesis of the Filamentous Ascomycete <i>Aspergillus nidulans</i>
(2006-02-24)Aspergilli comprise a heterogenous group of filamentous fungi. The ascomycete Aspergillus nidulans represents a well studied eukaryotic model system for metabolism and development. Aspergillus ... -
DAHP Synthasen aus Pilzen
(2002-07-09)The first step of the biosynthesis of the aromatic amino acids is the condensation of erythrose-4-phosphate and phosphoenolpyruvate to 3-deoxy-D-arabino-heptuloso-nate 7-phosphate. This ... -
Deneddylation and fungal development - Regulation of Nedd8 protein modification by DenA and the COP9 signalosome
(2012-08-16)Ubiquitin dependent protein degradation is a common principle in eukaryotic organisms to control appropriate temporal and spatial protein levels. Abnormal regulation leads to embryonic lethality in plants, insects and ... -
Developmental regulators and secreted effector molecules of the fungal pathogen Verticillium spp.
(2020-09-29)The haploid Verticillium dahliae and the allodiploid V. longisporum are two filamentous fungal pathogens, which colonize the plant vascular system of a broad host range including important crops. They survive outside of ... -
Governing fungal polar cell extension: Analysis of Rho GTPase and NDR kinase signalling in Neurospora crassa
(2008-05-16)Polar morphogenesis is required for the function of elongated cell types like neuronal cells, pollen tubes and cells of filamentous fungi. The basal signalling components involved are highly conserved. Defects in polar ... -
Interplay of Verticillium signaling genes favoring beneficial or detrimental outcomes in interactions with plant hosts
(2020-07-14)Verticillia and their plant hosts both contribute to pathogenesis as a consequence of their interaction. Evolution-driven genome extension includes hybridization, resulting in amphidiploid species as the rapeseed pathogen ... -
Localization and Stability of the Transcriptional Activator Gcn4p of Saccharomyces cerevisiae
(2003-02-27)The «general amino acid control« (GAAC) of the yeast Saccharomyces cerevisiae is a well characterized regulatory network which secures a sufficient amino acid supply of the organism. This ... -
Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)
(2010-01-21)The prolyl-4 hydroxylase domain enzymes 1-3 (PHD1-3) are involved in regulating the protein stability of the alpha subunit of the hypoxia inducible factor (HIF), which is the master regulator ... -
Phosphorylation dependent stability control of the deneddylase DenA and its impact on Aspergillus nidulans development
(2016-04-05)Summary Malfunctioning protein degradation in higher eukaryotes is associated with numerous diseases, including neurodegenerative disorders and cancer. Understanding regulation mechanisms of protein degradation is thus ... -
Protein Modification and Degradation in the Cell Cycle of the Yeast Saccharomyces cerevisiae
(2004-07-19)The anaphase-promoting complex or cyclosome (APC/C) is a large ubiquitin ligase essential for the mitotic and meiotic cell cycle. It ligates chains of ubiquitin to its target proteins marking ... -
Regulation of Flo11p-dependent adhesion in <i>Saccharomyces cerevisiae</i>
(2005-11-17)In der Bäckerhefe Saccharomyces cerevisiae kodiert FLO11 für ein Zell-Oberflächenprotein. Dessen Expression wird von verschiedenen Umweltbedingungen, wie Glukose-, Stickstoff- oder ... -
Regulation of fungal polar tip extension through NDR kinase signalling
(2010-07-20)NDR kinases play an important role in cell differentiation and morphogenesis. Until now, not much is known about the regulation of NDR kinases and the cross-communication between individual ...