Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Cramer, Patrick Prof. Dr."
Now showing items 1-6 of 6
-
Bioinformatic analysis of multi-omics data elucidates transcriptional cyclin dependent kinase mediated transcriptional regulation
(2022-08-01)Transcriptional regulation is a highly dynamic biological process which is governed by a complex network of proteins for precise expression of a gene. One of the most important regulators of gene expression are cyclin ... -
Reconstitution of the Integrator complex and its interaction with paused transcription elongation complex of Pol II-DSIF-NELF
(2021-10-19)The Integrator complex (INT) is the latest and largest multi-subunit protein complex to be added to the list of factors involved in RNA Polymerase II (Pol II) transcription. INT consist of 15 subunits with an estimated ... -
Structural studies of short nucleosome arrays containing linker histone H1
(2022-04-21)The DNA inside the eukaryotic nucleus is bound by octamers of histone proteins to form the nucleosome as the basic repeating unit of chromatin. Along the genome, nucleosomes locally form regularly spaced arrays. The relative ... -
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome and implications for chromatin remodelling
(2020-07-15)Eukaryotic cells condense their DNA into chromatin, which hampers the accessibility of genetic information. Nucleosomes are the smallest building blocks of chromatin and are comprised of an octameric core of histone proteins, ... -
Structure of the Pol II initation complex with TFIIH and core Mediator and mechanistic implications for transcription
(2018-03-13)The transcription of protein coding genes is a key step in the conversion of genomic information into the content of a cell’s proteome. In eukaryotes, this process is performed by the multi-subunit DNA-dependent RNA ... -
Transcriptome maps of general eukaryotic RNA degradation factors and identification and functional characterization of the novel mRNA modification N<sup>3</sup>-methylcytidine
(2019-07-01)The first part of this dissertation focused on the different RNA degradation pathways in the yeast Saccharomyces cerevisiae (S. cerevisiae). We used the method photoactivatable ribonucleoside-enhanced crosslinking and ...