Blättern Fakultät für Biologie und Psychologie (inkl. GAUSS) nach "Engel, Wolfgang Prof. Dr. Dr." Betreuer
Anzeige 1-20 von 22
-
Analysis of coiled coil domain containing 33 protein (CCDC33) and determination of infertility causes in mutant mouse line with the deletion of six germ cell-specific genes
(2013-02-27)Since most cases of male infertility remain idiopathic, analysis of the mechanism in which genes are involved in spermatogenesis control might help to better understand the reasons. This thesis consists of 2 parts concerning ... -
Analysis of the Role of Piwil2 gene in Tumorigenesis and Germline Stem Cell Metabolisms
(2006-05-18)The genes of the piwi family are defined by conserved PAZ and Piwi domains and play important roles in stem cell self-renewal, RNA silencing and translational regulation in various organisms. ... -
Comparative Analysis of Embryonic Stem Cells and Multipotent Adult Germline Stem Cells at the Level of Transcriptome and Proteome
(2011-04-01)Pluripotency of different stem cell types is a complex biological state which allows the cells to continuously proliferate (self-renewal) but also primes them for differentiation into all ... -
Elucidation of Theg Gene Role in Spermatogenesis and Characterisation of a Novel Spontaneous Mutation Named “nax” in Mouse
(2003-02-11)In the present study, a differentially expressed gene, named Theg, expressed specifically in spermatids, is characterised. Its expression is up regulated by some unknown factor/s from Sertoli ... -
Expression and functional analysis of the germ cell specific genes ADAM 27 and Testase 2
(2004-02-12)In the present study two members of the ADAM family of proteins, murine ADAM 27 and Testase 2, were characterized. Both genes are expressed specifically in the testicular germ cells and therefore are postulated to be ... -
Expression and Functional Analysis of Vsig1 Gene
(2009-05-27)The aims of this study were to determine expression pattern and subcellular localization of VSIG1, a novel member of the immunoglobulin superfamily, and to analyse the function of the Vsig1 ... -
Functional Analysis of Insl5 and Insl6 Genes and Verification of Interactions between Pelota and its Putative Interacting Proteins.
(2009-11-27)The aims of the study were to determinate expression and function of two members of insulin like family, namely Insl5 and Insl6 and to verify the interactions between PELO and its putative ... -
Funktionelle Analyse des murinen Foxq1 Gens und die Charakterisierung magenspezifischer Gene
(2007-11-09)This work clearly demonstrates an involvement of Foxq1 in gastric acid secretion. Our results let us suggest, that Foxq1 takes part in the organisation of tubulovesicle transport or the ... -
Funtional Analysis of the Murine Genes, MOCS1 and Sox15
(2003-08-06)In this work, function of the murine genes, MOCS1 and Sox15 were investigated. Human molybdenum cofactor deficiency is a rare and devastating autosomal-recessive disease for which no therapy ... -
In vivo- und in vitro-Funktionsanalysen von Bax Inhibitor-1 bei humanen Karzinomzellen
(2007-05-29)Apoptosis is a form of programmed cell death, which is regulated by numerous gene products. Many of these genes are mutated or deregulated in human carcinoma. Bax inhibitor-1 (BI-1) gene ... -
Molecular and Functional Analysis of two Gene Trap Mouse Lines
(2004-05-10)For better understanding of the mechanisms regulating mammalian embryonic development, the isolation and characterization of new genes involved in this mechanism is important. A useful tool ... -
Novel interaction partners of the chromatin remodeler CHD7, a protein mutated in CHARGE syndrome
(2012-09-14)Summary CHARGE syndrome, an autosomal dominant inherited multiple malformation syndrome is caused by mutations in the chromodomain helicase DNA binding protein 7 gene (CHD7). In 10% of ‘typical’ CHARGE patients and 40-50% ... -
Pluripotency of multipotent adult germ-line stem cells: analysis of apoptotic and epigenetic features
(2012-05-10)Pluripotency is the potential of cells to proliferate incessantly (self-renewal) and to develop into all cell types of the three germ layers as well as to the germ line. Recently established multipotent adult Germ-line ... -
Studies on Expression and Function of Vsig1 Gene
(2011-03-11)The aim of this study was to determine the expression pattern of Vsig1 during testis development and analysis of the conditional Vsig1knockout mouse, transgenic Cyto-Vsig1 and Villin-Vsig1 ... -
Die Suszeptibilität der prämeiotischen und meiotischen männlichen Keimzelle zur malignen Transformation
(2001-07-25)Until now it is not known at which specific stage of spermatogenesis the germ cell gets its potency to malignant transformation. In the present thesis the susceptibility of premeiotic and ... -
The PHD finger protein 5 is a part of the spliceosome and acts as a DNA-binding protein
(2005-12-06)Four proteins namely U2AF35, SRp40, mDomino and Ddx1 were identified as PHF5a interacting partners by using the murine 11.5-days embryo yeast two-hybrid library screening.PHF5a interacting ... -
The susceptibility of primordial germ cells to malignant transformation and isolation and characterization of members of a new gene family differentially expressed in invasive and non-invasive immortalized male germ cells
(2002-03-08)In this study, we examined the susceptibility of primordial germ cells (PGCs) to malignant transformation using a transgenic mouse model. In this model we used the simian virus 40 (SV40) ... -
Über die funktionelle Analyse des murinen peroxisomalen Testis-spezifischen Gen 1 (Pxt1)
(2010-11-26)Mammalian spermatogenesis is a complex biological process by which diploid spermatogonia differentiate into specialized haploid spermatozoa. Regulation of male gametogenesis involves a ... -
Zur Funktion von Leupaxin beim Karzinom der Prostata
(2006-12-13)Prostate cancer is the most frequent cancer in man and the second leading cause of cancer related deaths in western countries. The cancer first developes as an androgen-dependent lesion, ...