Blättern Fakultät für Biologie und Psychologie (inkl. GAUSS) nach "Hardeland, Rüdiger Prof. Dr." Betreuer
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A Role for Glycogen Synthase Kinase 3 beta in the Regulation of Glucagon Gene Transcription by Insulin
(2003-11-21)Insulin binding to its receptor on the a-cells in endocrine pancreas initiates a signalling cascade that results in inhibition of glucagon gene transcription. Evidence suggests that the ... -
Anti-Apoptosis and Regeneration in the Visual System: Effects of BAG1 (Bcl-2-associated athanogene-1)
(2008-04-28)In the present work, we investigated Bcl-2-associated athanogene-1 (BAG1) as a therapeutic molecule in the lesioned visual system in vivo. The effects of BAG1 were tested in two in vivo models of apoptosis and regeneration, ... -
BEHAVIOURAL AND PHARMACOLOGICAL VALIDATION OF CHRONIC SOCIAL STRESS AS A MODEL OF DEPRESSIVE-LIKE SYMPTOMS IN RATS
(2006-06-22)In order to develop a model of chronic social stress in rats, in the first study the male Wistar rats were subjected to five weeks daily exposure to social defeat. This protocol resulted ... -
CaMKII-dependent regulation of ion channels and its role in cardiac arrhythmias
(2008-07-24)Intracellular calcium (Ca2+) is a central second messenger, which translates the electrical signal into cardiac contraction. This process is termed excitation-contraction coupling (E-C ... -
Cell-penetrating peptide-enhanced delivery of heat shock proteins in models of neurodegeneration
(2008-04-30)The hallmark of Parkinson's disease (PD) is the loss of dopaminergic (DA) neurons in the substantia nigra (SN), the depletion of striatal dopamine levels, and the presence of intraneuronal proteinaceous cytoplasmatic ... -
Charakterisierung von Mikrogliafunktionen im Simianen Immundefizienzvirus (SIV) - Rhesusaffentiermodell für AIDS
(2009-01-23)Nearly 60% of patients infected with HIV are affected by neurological and psychiatric symptoms. The motor and cognitive dysfunctions, as well as behavioral changes are described by the term ... -
Eskalierendes Commitment und präferenzkonsistente Informationsbewertung
(2006-07-14)The PhD thesis offers a new explanation for escalation of commitment. Escalation of commitment is the tendency to persist in losing courses of action or to throw good money after bad. ... -
Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
(2004-11-18)Hepatic stellate cells (HSCs) and liver myofibroblasts (LMFs) represent major cell populations involved in liver fibrogenesis. Several lines of evidence demonstrate that in contrast to LMFs, ... -
Functional analysis of IGFBP-2 overexpression in mouse liver myofibroblasts: Therapeutic implication for liver fibrogenesis
(2008-05-20)Liver fibrosis is characterized by abnormal accumulation of extracellular matrix (ECM) proteins which are secreted from the cells of the fibroblast lineage during chronic liver injury. Different liver cell populations ... -
Functional characterization of the human renal organic anion transporter 3 (hOAT3) and comparison to hOAT1
(2004-06-01)Renal secretion of organic anions is critically dependent on their basolateral uptake against the electrochemical gradient. Due to their localization, two transporters are likely involved, ... -
Funktionelle Analyse von MHC-Klasse-I-Genen der Rhesusaffen (<i>Macaca mulatta</i>)
(2008-09-01)This thesis focuses on the structure and function of rhesus macaque (Macaca mulatta, Mamu) major histocompatibility complex (MHC) class I genes. As the cellular immune response is at least ... -
Funktionelle Analysen deregulierter Signalwege transformierter B-Lymphozyten - Das Epstein-Barr-Virus-Onkogen LMP1
(2007-06-20)The development of different tumor entities can often be correlated with a viral infection. One of this tumor associated viruses is the Epstein-Barr virus (EBV). More than 90% of the human ... -
Hilfeverhalten und Zivilcourage: Ein Vergleich von antizipiertem und realem Verhalten
(2009-03-03)So far, there have been few experimental studies concerning the similarities and differences of helping behavior and civil courage. In contrast to research on helping behavior, there is ... -
Interaktion von Leukozyten mit endothelialen Adhäsionsmolekülen und ihre Inhibition durch Expression von konkurrierenden Fusionsproteinen
(2002-06-05)The adhesion of inflammatory leukocytes to vascular endothelium and their recruitment into the vessel wall are phenomenons of chronical diseases that have to be treated. Vascular cell ... -
Konsequenzen der Expression des Ether à go-go Kaliumkanals
(2006-08-02)This work provides the first description of a highly effective and specific siRNA-based inhibitor for the potential oncogene hEAG1 (human ether à go-go channel), which proved to be ... -
Neuroautonome Regulation und deren emotionale Modulation bei Mäusen
(2005-05-20)In this dissertation, characteristic somatomotor-, neuroautonomic- and endocrine responses of mice to external stimuli with innate or learned aversive attributes were investigated. Unconditioned ... -
Neuroligin: Charakterisierung eines neuronalen Transmembranproteins
(2004-02-06)Synapses are highly specialized contact sites where the communication between nerve cells takes place. Cell adhesion proteins are the key regulators of synaptogenesis and modulation. The ... -
Oxidativer Metabolismus von Kynurensäure und ihren Analoga
(2002-02-05)In the following work I am examining the oxidative metabolism of kynurenic acid by taking also into consideration the enzymatic and non-enzymatic reaction phases. Therefore, I used, on one ... -
Pharmakologische Untersuchungen zu endokrinen Effekten des UV-Filters Ethylhexyl-methoxycinnamat
(2006-05-31)During the last years it has become apparent that an increased exposure to UV-irradiation is accompanied by noxious side effects. Ethylhexyl-methoxycinnamate (OMC), a cinnamate derivative, ... -
Regulation des mitochondrialen Zerfalls innerhalb der neuronalen Apoptose
(2007-05-23)Under physiological conditions, mitochondrial morphology dynamically shifts between a punctuate appearance and tubular networks by fission and fusion events. Mitochondrial apoptosis pathways ...