Blättern Fakultät für Biologie und Psychologie (inkl. GAUSS) nach "Nave, Klaus-Armin Prof. Dr." Betreuer
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A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia
(2012-12-07)Summary A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia Schizophrenia (SZ) is as severe and phenotypically as well ... -
Cell type specific transcriptomic characterization of myelin abnormalities
(2022-08-22)Myelin is indispensable for the fast and efficient transmission of electric signals along axons. The formation of myelin by oligodendrocytes in the central nervous system (CNS) is tightly regulated at the transcriptional ... -
Characterization of the neuronal proteolipids M6A and M6B and the oligodendroglial tetraspans PLP and TSPAN2 in neural cell process formation
(2012-07-12)The tetraspan-transmembrane proteins of the M6-proteolipid proteolipid protein family are among the most abundant cell surface proteins in neurons. Their cellular function has remained largely speculative, also because ... -
Genetic Evidence For Neuron-Glia Metabolic Coupling In The CNS
(2016-07-27)The active contribution of oligodendrocytes and astrocytes to sustain brain physiology was completely underestimated, but severe consequences of their dysfunction in various diseases and glia-specific mutants emphasized ... -
Myelin lipids are energy reserves in the nervous system
(2021-03-18)Neuronal functions critically depend on a continuous supply of glucose as prolonged hypoglycemia can lead to severe brain injury. It is surprising that except for astroglial glycogen the brain has no visible energy reserves. ... -
Role of myelin-associated NAD+- dependent deacetylase Sirtuin 2 in modifying axonal degeneration
(2013-01-25)In the central nervous system (CNS), oligodendrocytes (OLs) ensheath axons with lipid-rich myelin membranes that provide an electrical insulation and are essential for fast nerve impulse transmission. However, myelination ... -
Subcellular trafficking of proteolipid protein (PLP/DM20) and novel mechanisms of ER retention in Pelizaeus-Merzbacher disease
(2006-11-22)Missense mutations that predict the misfolding of membrane proteins have been associated with a number of neurogenetic diseases. However, it is not known how apparently minor changes in the ...