Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Bastians, Holger Prof. Dr."
Now showing items 1-4 of 4
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CEP72 represents a putative Oncogene that negatively regulates the mitotic Function of Brca1 and induces Chromosomal Instability
(2015-10-26)Proper progression through mitosis ensures the maintenance of whole chromosomal stability in a eukaryotic cell. Hence, failures during this tightly regulated process can lead to the perpetual mis-segregation of whole ... -
Characterizing the SUMOylation of APC4 and the Function of APC4 Within Neurons
(2021-09-23)The Anaphase Promoting Complex (APC/C) is an E3 ubiquitin ligase that is involved in multiple molecular processes in eukaryotic cells. It is regulated by an intricate system of post-translational modifications that enables ... -
Molecular mechanisms of replication stress-induced mitotic chromosome missegregation
(2022-12-09)Chromosomal instability (CIN), the process of the generation of structural and numerical changes in the karyotype, is a major hallmark of human cancer generating genetic variation, thereby driving tumor evolution and ... -
Role of N-glycosylation for the function of E-cadherin in tissue morphogenesis
(2022-12-14)E-cadherin is central to the formation, stabilization, and maturation of adherens junctions, which serve to physically link epithelial cells and transmit mechanical pulling forces from the outside to the actomyosin cortex ...