Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Burckhardt, Gerhard Prof. Dr."
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Adenovirus-mediated gene transfer of FK506-binding proteins FKBP12.6 and FKBP12 in failing and non-failing rabbit ventricular myocytes
(2004-09-27)The FK506-binding proteins (FKBPs) FKBP12 and FKBP12.6 influence the Ca2+-release from the sarcoplasmic reticulum (SR) in skeletal and heart muscle, respectively, via regulation of the SR ... -
Characterization of a human renal organic anion transporter
(2001-05-02)The renal excretion of organic anions, including a variety of endogenous substances, xenobiotics and their metabolites, involves an organic anion transport system with multiple specificity. ... -
Cloning and characterization of organic anion systems in the adrenal cortex and their role in steroid release
(2001-06-06)The adrenal steroid hormones have a central role in maintaining homeostasis, as they have influence on almost every physiological process. Their movement across the cell membrane is still ... -
Functional characterization of the human renal organic anion transporter 3 (hOAT3) and comparison to hOAT1
(2004-06-01)Renal secretion of organic anions is critically dependent on their basolateral uptake against the electrochemical gradient. Due to their localization, two transporters are likely involved, ... -
Molecular mechanisms of the cytokine-dependent induction of the heme oxygenase-1 gene: in vivo and in vitro studies
(2004-09-27)Heme oxygenase 1 (HO-1) is the inducible enzyme which catalyzes the rate-limiting reaction of heme degradation yielding carbon monoxide (CO), divalent iron (Fe2+), and biliverdin. Due to a ... -
OCT1-mediated cellular drug uptake and interactions between drug transport and drug metabolism
(2012-12-07)OCT1 is a polyspecific organic cation transporter belonging to the solute carrier gene family SLC22. Human OCT1 is mainly expressed on the sinusoidal membrane of hepatocytes and thus may play an important role in ... -
Role of transport systems in cortisol release from human adrenal cells
(2004-05-25)Adrenal steroid hormones (e.g., cortisol) play a pivotal role in the regulation and maintenance of metabolic homeostasis. The secretion of glucocorticoids from adrenocortical cells into ... -
Transcriptional Regulation of human Plasminogen Activator Inhibitor-1 Gene Expression by Insulin-like Growth Factor-1, Insulin and Upstream Stimulatory Factor-2
(2005-11-11)PAI-1 inhibits conversion of the proenzyme plasminogen to the active protease plasmin and modulates proteolytic processes associated with pathophysiological conditions such as prethrombotic ...