Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Dobbelstein, Matthias Prof. Dr."
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Biochemical characterization of human shieldin complex
(2022-08-01)Shieldin is a newly identified DNA repair effector involved in repair of double strand breaks (DSBs) in G1 phase of cell cycle. Shieldin is a four-component complex consisting of proteins SHLD1, SHLD2, SHLD3 and HORMA REV7. ... -
Bioinformatic analysis of multi-omics data elucidates transcriptional cyclin dependent kinase mediated transcriptional regulation
(2022-08-01)Transcriptional regulation is a highly dynamic biological process which is governed by a complex network of proteins for precise expression of a gene. One of the most important regulators of gene expression are cyclin ... -
Characterization of the Oncogenic Role of BCL9-2 in Breast Tumorigenesis
(2012-05-16)One of a few highly conserved signaling pathways, which regulate cell proliferation and tissue organization during embryogenesis and in the adult organism, is the Wnt/beta-catenin signaling cascade. The mutations of ... -
Dissecting the ß-catenin-dependent and -independent functions of BCL9 and BCL9-2 in intestinal tumorigenesis
(2013-04-26)The Wnt/ß-catenin signaling pathway is highly conserved and plays an important role during embryonic development, in adult homeostasis and tumorigenesis. The members of the novel BCL9 family were characterized as co-activators ... -
Interaction of the Hedgehog and vitamin D receptor signaling pathways in Patched associated cancers
(2015-05-12)Tumor formation can be linked to the misregulation of the developmentally important Hedgehog (Hh) signaling pathway. In general, Hh signaling is initiated by the secretion of Hh ligands. This is followed by the binding of ... -
Mechanisms of homologous chromosome synapsis and recombination in mammalian meiosis
(2022-10-13)Homologous chromosome synapsis and recombination are key events that occur during meiotic prophase and result in the formation of chromatin structures called chiasmata. These chromatin structures physically connect ... -
NF-ĸB mediated signaling mechanisms in epidermal homeostasis and carcinogenesis
(2013-09-16)The transcription factor NF-κB is a major player in a wide variety of crucial cellular functions such as proliferation, apoptosis, invasion as well as inflammation. However in the human epidermis, opposite, growth inhibitory ... -
Novel proapoptotic p63 isoforms are driven by an endogenous retrovirus in the male germ line of humans and great apes, likely increasing genome stability
(2011-05-04)TAp63, a homolog of the tumor suppressor p53, has the capability to protect the female germ line by eliminating oocytes that suffered severe DNA damage upon irradiation. Though expression ... -
Die Rolle von Wnt5a bei der Regression des Basalzellkarzinoms
(2013-01-04)Basal Cell Carcinomas (BCCs) are the most commonly diagnosed tumors among people in the western world. Interestingly, approximately 20% of BCCs show signs of spontaneous regression. Regression of BCCs also occurs in ... -
The kinase MK2 in DNA replication upon genotoxic stress and chemotherapy
(2013-01-11)DNA damage constitutes a constant threat to genomic integrity. Cells evolved programs controlled by a complex signaling network to cope with these lesions in order to avoid tumorigenesis. These cellular processes and ... -
The NF-κB signaling pathway in melanoma cells and implications for its therapeutic modulation
(2012-12-10)One of the major challenges in cancer therapy is to overcome drug resistance. Melanoma cells are an illustrative example for this notion, as metastasized melanoma is almost universally resistant against chemotherapy. The ... -
Treatment of acute Graft-versus-Host Disease using inorganic-organic hybrid nanoparticles
(2019-12-04)Acute Graft-versus-Host Disease (aGvHD) is a severe complication of allogeneic hematopoietic stem cell transplantation, which is induced by donor T cells that become stimulated after recognizing recipient proteins as ...