Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Doenecke, Detlef Prof. Dr."
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Die Bedeutung der subzellulären CaMKIIδ-Überexpression auf den intrazellulären Ca2+-Stoffwechsel in Herzmuskelzellen
(2007-04-17)The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase. It is formed as a multimer consisting of 6 to 12 monomers. CaMKIIδ, the ... -
Brain derived neurotrophic factor (BDNF): Untersuchungen zur Expression und Regulation in vitro sowie zur funktionellen Relevanz in der experimentellen autoimmunen Enzephalomyelitis (EAE)
(2010-07-14)The neurotrophin brain derived neurotrophic factor (BDNF) is essential for the development and maintenance of the nervous system. Neurons are the main cellular source of this neurotrophin, ... -
CaMKII-dependent regulation of ion channels and its role in cardiac arrhythmias
(2008-07-24)Intracellular calcium (Ca2+) is a central second messenger, which translates the electrical signal into cardiac contraction. This process is termed excitation-contraction coupling (E-C ... -
Cell-penetrating peptide-enhanced delivery of heat shock proteins in models of neurodegeneration
(2008-04-30)The hallmark of Parkinson's disease (PD) is the loss of dopaminergic (DA) neurons in the substantia nigra (SN), the depletion of striatal dopamine levels, and the presence of intraneuronal proteinaceous cytoplasmatic ... -
Characterization of cytoplasmic bodies involved in 5' to 3' mRNA degradation in human cells
(2008-04-23)In the context of gene expression regulation, discontinuing translation of mRNAs occurs by evolutionarily conserved mechanisms whose executors have been described to be associated with various types of cytoplasmic ... -
Charakterisierung von funktionellen Oberflächenstrukturen des Hepatitis-B-Virus Nukleokapsids
(2005-12-28)During hepatitis B virus (HBV) morphogenesis the transmembrane large envelope protein (L protein) probably directly interacts with mature cytosolic nucleocapsids. The shell of the capsid ... -
Crystal structure analysis of selenocysteine biosynthesis components
(2010-11-04)Some organisms from all three domains of life eukaryotes, bacteria and archaea, incorporate selenocysteine (Sec) into fractions of their proteins. Sec synthesis takes place on its ... -
Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
(2004-11-18)Hepatic stellate cells (HSCs) and liver myofibroblasts (LMFs) represent major cell populations involved in liver fibrogenesis. Several lines of evidence demonstrate that in contrast to LMFs, ... -
Expressionsanalyse des humanen Histonsubtyps H1x
(2008-06-02)Nuclear eukaryotic DNA is organised as chromatin in conjunction with proteins. The basal structural organisation unit of chromatin is the nucleosome consisting of the nucleosome core particle, ... -
Functional analysis of IGFBP-2 overexpression in mouse liver myofibroblasts: Therapeutic implication for liver fibrogenesis
(2008-05-20)Liver fibrosis is characterized by abnormal accumulation of extracellular matrix (ECM) proteins which are secreted from the cells of the fibroblast lineage during chronic liver injury. Different liver cell populations ... -
Functional Analysis of Two Major Sperm Tail Proteins Identifies ODF1 as Being Essential for the Tight Linkage of the Sperm Head to the Tail via SPAG4 and ODF2 as A Component of the β-catenin Destruction Complex
(2015-04-02)In the mammalian sperm tail, the outer dense fibers (ODFs) are accessory fibers accompanying the axonemal tubuli doublets on their outer site. The ODFs are composed of at least 14 polypeptides of which only a few have been ... -
Funktionelle Charakterisierung der Transkriptionsfaktoren Nkx2.2 und Arx in der Entwicklung der endokrinen Zellen im murinen Pankreas
(2011-09-08)The pancreas is a compound-gland structured into two functional units exhibiting exocrine and endocrine properties. Exocrine cells produce and secret digestive enzymes, whereas endocrine ... -
Identification and characterization of Campylobacter jejuni factors relevant for the infection process
(2007-10-09)Campylobacter jejuni is the most frequent bacterial cause of foodborne-illness in the developed world including Germany, where the reported number is 60,000 cases in a year. Despite the ... -
Local Protein Turnover As a Regulatory Mechanism of Growth and Collapse of Neuronal Growth Cones
(2005-05-11)The axonal growth cone is remarkably sensitive to chemical and mechanical cues from its environment that enables it to make autonomous morphological restructuring decisions. Depending on ... -
Mechanisms underlying the nuclear transport of histones and histone-related proteins
(2005-11-11)The CCAAT-specific transcription factor NF-Y is a heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC. Each subunit contains an evolutionarily conserved core region, comprising a ... -
Molecular mechanisms of myelin membrane biogenesis
(2008-03-26)During vertebrate brain development, axons are ensheathed by myelin, an insulating membrane generated by oligodendrocytes. Our aim is to elucidate the cellular machinery that is required for the formation of this membrane. ... -
Neuroaxonale Schädigung in experimentellen Modellen der multiplen Sklerose
(2008-08-28)Multiple sclerosis (MS) is the commonest non-traumatic neurological disease leading to permanent disability in young adults and is considered to be autoimmune in nature. The hallmarks ... -
Neuroligin: Charakterisierung eines neuronalen Transmembranproteins
(2004-02-06)Synapses are highly specialized contact sites where the communication between nerve cells takes place. Cell adhesion proteins are the key regulators of synaptogenesis and modulation. The ... -
Nuclear import of histone fold motif containing heterodimers by importin 13
(2009-08-03)In this study, we have analyzed the nuclear import of two related histone fold pairs, CHRAC-15/17 and p12/CHRAC-17. The CHRAC-15/17 heterodimer is part of the chromatin accessibility complex ... -
Nuclear transport of the DNA fragmentation factor via the classical importin α/β-pathway
(2007-11-02)One of the biochemical hallmarks of apoptosis is internucleosomal DNA fragmentation mediated by the endonuclease DNA fragmentation factor (DFF) 40. In proliferating cells DFF40 is expressed ...