Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Ehrenreich, Hannelore Prof. Dr. Dr."
Now showing items 1-20 of 20
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Ablation of cell-specific cholesterol synthesis affects cerebral β-amyloidosis
(2023-03-13)Cholesterol, an essential membrane component, among others modifies membrane fluidity and regulates cell signaling. CNS cholesterol metabolism is separated from peripheral cholesterol by specific properties of the ... -
Amyloid-beta driven changes in transcriptome plasticity: From OMICS to Therapy
(2016-04-06)Alzheimer’s disease is characterized by a progressive cognitive decline coinciding with the formation of amyloid plaques and tau fibrils in the human brain. It is the most common form of dementia and the number of people ... -
Analysis of Myelin Membrane Growth in Oligodendrocytes
(2015-12-07)Nervous systems of mammalian organisms are composed of various cell types with different morphology, function and connectivity. Understanding this complicity from a molecular point of view requires the application of ... -
Characterization of the invasion of hematopoietic myeloid cells into the CNS during EAE
(2022-12-01)Experimental autoimmune encephalomyelitis (EAE), the classical animal model of multiple sclerosis, is caused by T cells directed against myelin antigens. Upon intravenous transfer, these cells appear in the vessels of the ... -
Conditional activation of NRG1 signaling in the brain modulates cortical circuitry
(2015-12-01)Neuregulin (NRG) 1 contains an epidermal growth factor (EGF)-like signaling domain and serves as a ligand for receptor tyrosine kinases of the ErbB family. ErbB4, the main neuronal NRG1 receptor in the brain, is enriched ... -
Effects of recombinant human erythropoietin in the cuprizone mouse model of de- and remyelination
(2012-06-14)Erythropoietin (EPO) has potent neuroprotective/neuroregenerative properties in various forms of experimental autoimmune encephalomyelitis (EAE), i.e. established rodent models of acute multiple sclerosis (MS), and in ... -
Encoding, coordination, and decision making in the primate fronto-parietal grasping network
(2017-09-22)The processes taking place in our brain allow us to flexibly interact with our surrounding based on our internal demands. This requires perceptual information processing up to the generation of movements taking place in ... -
Erythropoietin-mediated neuroprotection in insects
(2016-08-30)The cytokine erythropoietin (Epo) initiates adaptive cellular responses to a variety of mechanical and physiological insults in various non-hematopoietic mammalian tissues including the nervous system. Previous studies on ... -
Evaluation neuroprotektiver Strategien am Beispiel ausgewählter neurodegenerativer Erkrankungen: Amyotrophe Lateralsklerose und Alkoholabhängigkeit
(2007-06-19)Although neurodegenerative diseases have high prevalence rates and a poor prognosis, hardly any promising etiological treatment options are available. Within the next years, a cure of these ... -
Expression and function of erythropoietin and its receptor in invertebrate nervous systems
(2010-02-08)This doctoral study provided substantial evidences for the presence of the EPO/EPOR signalling system in the CNS of invertebrates from different phyla (chapter 2) and demonstrated neuroprotective ... -
Genetic Evidence For Neuron-Glia Metabolic Coupling In The CNS
(2016-07-27)The active contribution of oligodendrocytes and astrocytes to sustain brain physiology was completely underestimated, but severe consequences of their dysfunction in various diseases and glia-specific mutants emphasized ... -
Genetic variants of EPO and EPOR influence cognitive core features of schizophrenia
(2011-03-18)Introduction: Erythropoietin (Epo), a hematopoietic growth factor, has long been observed to improve cognition but this effect was attributed to the increase in hemoglobin levels. Even after ... -
Myelin lipids are energy reserves in the nervous system
(2021-03-18)Neuronal functions critically depend on a continuous supply of glucose as prolonged hypoglycemia can lead to severe brain injury. It is surprising that except for astroglial glycogen the brain has no visible energy reserves. ... -
Neuroendocrine effects of the endocrine disruptors Vinclozolin and Equol in the adult male rat
(2007-11-21)Numerous anthropogenic chemicals and natural plant-derived products can mimic or disrupt the normal function of endogenous sex steroid hormones by direct interaction with their specific nuclear receptors. These compounds ... -
Prädiktion von Therapieerfolg und Verlauf psychiatrischer Komorbidität bei prognostisch benachteiligten Alkoholkranken
(2005-02-16)This thesis comprises two articles which are concerned with the prediction of therapy outcome and course of psychiatric comorbidity in chronic multimorbid addicts.Article 1Objective: The ... -
Role of Neuroligin-2 and its Interacting Inhibitory Synapse Organizers in the Circuits of Fear Learning and Anxiety
(2022-06-03)Neuroligin-2 (Nlgn2) is a synaptic adhesion molecule that promotes the maturation and function of inhibitory synapses. Lack of Nlgn2 in mice produced a reduction in inhibitory synaptic transmission in many brain regions. ... -
Ryanodine receptors in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis
(2015-10-19)The activation of auto-aggressive T cells is crucial for the development of autoimmune diseases, such as multiple sclerosis (MS) or its animal model experimental autoimmune encephalomyelitis (EAE). T cell activation relies ... -
Therapieprozess- und Ergebnisforschung in der Ambulanten Langzeit-Intensivtherapie für Alkoholkranke (ALITA)
(2007-06-06)This thesis comprises two articles which investigate the mechanisms of action of the Outpatient Longterm Intensive Therapy for Alcoholics (OLITA).Article 1Context: Studies on supervised longterm ... -
Tyrphostin AG126 modulates Toll-like receptor (TLR) activation-induced functions in microglia by protein tyrosine kinase (PTK) -dependent and -independent mechanisms
(2010-10-25)Tyrphostins comprise a class of synthetic protein tyrosine kinase (PTK) inhibitors structurally derived from tyrosine and aimed at the specific prevention of substrate phosphorylation. The ... -
Zur Rolle der Therapeutenrotation und von Patientenmerkmalen für die Wirksamkeitsprozesse der Ambulanten Langzeit-Intensivtherapie für Alkoholkranke (ALITA)
(2004-07-09)This thesis comprises two articles which are concerned with the process and outcome research on the Outpatient Long-term Intensive Therapy for Alcoholics.For nine years, the so-called ...