Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Einsle, Oliver Prof. Dr."
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Die Bedeutung der Proteine 4.1G und 4.1N für den Aufbau und die Funktion glutamaterger Synapsen
(2009-09-14)In the present study, the role of proteins 4.1G and 4.1N for the synaptic localisation of AMPA receptors and neurotransmission at glutamatergic synapses in the mouse brain has been examined. ... -
Biochemische Charakterisierung von PpoA aus Aspergillus nidulans
(2010-02-17)In the present work Psi-factor- producing oxygenases from Aspergillus nidulans, so called Ppo-enzymes have been studied and characterized. These enzymes are known to possess regulatory ... -
Blue light-dependent development of the filamentous fungus Aspergillus nidulans
(2007-11-22)Numerous studies have revealed that fungal development and the production of secondary metabolites are linked although the molecular mechanisms are yet unknown. Light seems to be one of the ... -
Chararcterisation of fungal protein kinases involved in the regulation of the cell cycle of Saccharomyces cerevisiae and of sexual development in Aspergillus nidulans
(2007-11-22)In this work, fungal model organisms, the single cell budding yeast Saccharomyces cerevisiae and the filamentous fungus Aspergillus nidulans were used to characterize different factors ... -
Crystal structure of a human U5 snRNP specific binary complex and crystal structure of a histone deacetylase-like bacterial amidohydrolase
(2005-12-09)The crystal structure of the complex comprising the GYF-domain of U5-52K and the U5-15K protein has been determined at 2.35 Å resolution. The protein U5-52K (Lin1p) is a component of yeast ... -
Crystallographic studies on a cold adapted subtilase and proteins involved in mRNA processing
(2005-06-03)The crystal structure of a subtilisin-like serine proteinase from the psychrotrophic marine bacterium, Vibrio sp. PA-44, was solved by means of molecular replacement and refined at 1.84 Å ... -
„Ex vivo” Replikation des pathogenen Prion Proteins
(2007-01-29)The prion protein (PrP) is an ubiquitous protein. Prion stands for proteinaceous infectious particle and is according to the 'protein-only hypothesis' the infective agens of the transmissible ... -
Functional and structural investigation of spliceosomal snRNPs
(2009-01-20)The expression of most eukaryotic protein-encoding genes involves precursor messenger RNA (pre-mRNA) processing steps including pre-mRNA splicing. Pre-mRNA splicing is catalyzed by a ... -
Kristallisation von GGA-Proteinen und röntgenkristallographische Untersuchungen am Cα-Formylglycin Generierenden Enzym
(2007-03-05)GGA proteins are a family of monomeric clathrin adaptors that mediate the sorting of mannose-6-phosphate receptors between the trans-Golgi network and endosomes. Crystal structures of isolated GGA protein VHS, GAT and GAE ... -
Kristallstrukturanalyse des spleißosomalen DEAD-Box Proteins hPrp28
(2008-06-25)DEAD-box proteins belong to the helicase superfamily. They use the energy of ATP hydrolysis to dissociate RNA-RNA or RNA-protein interactions and therefore to catalyze rearrangements in ... -
Mobilisierung von Speicherlipiden in <i>Cucumis sativus</i>- und <i>Arabodopsis thaliana</i>-Keimlingen
(2008-12-12)Germination of oilseeds is characterized by mobilisation of TAGs that are stored in lipid bodies and serve as carbon source. Beside the classical degradation pathway of these storage ... -
Neue Enzyminhibitoren und Rezeptoragonisten durch Variation funktionaler Schleifen von Mikroproteinen
(2005-10-25)Cystine knot microproteins are peptidic biomolecules with approximately 28-40 amino acids in length. They are able to fold into extremely stable threedimensional structures characterized ... -
Ein neuer Syntheseweg für wertvolle Fettsäuren in Saccharomyces cerevisiae und Arabidopsis thaliana
(2009-04-03)The production of very long chain fatty acids (VLCPUFAs) with relevance for human nutrition in transgenic oilseeds represents a major challenge for plant biotechnology. Up to now, VLCPUFA ... -
Präparation und röntgenkristallographische Untersuchungen an archaebakteriellen Box C/D sRNPs und einer neuartigen Glukosyltransferase aus Thermotoga maritima MSB8
(2005-10-18)A variety of posttranscriptional nucleotide modifications in ribosomal ribonucleic acids (RNAs) are directed by nucleolar RNAs (snoRNAs). The two major classes involved in these modifications ... -
Purification and crystallization of spliceosomal snRNPs
(2009-02-26)In eukaryotes, the non-coding sequences (introns) of precursor messenger RNA are excised by a large ribonucleoprotein complex, the spliceosome. The core components of the spliceosome are ... -
Structural Analysis of the 50S Ribosomal Stalk
(2007-06-27)Protein biosynthesis represents a dynamic process that takes place on the ribosome and is driven by translation factors. Some of these factors are GTP binding proteins. They possess a limited ... -
Structural and biochemical characterization of diheme <i>c</i>-type cytochromes
(2008-12-04)Cytochromes are an abundant family of proteins incorporating heme as a prosthetic group and are involved in processes of electron conduction or redox reactions. Heme consists of an aromatic ... -
Structural characterization of the two copper proteins nitrous oxide reductase from Pseudomonas stutzeri and laccase Lcc5 from Coprinopsis cinerea
(2011-08-24)Although, the reduction of nitrous oxide (N2O) is highly exergonic, a high activation barrier hinders a spontaneous reaction. With regard to inertness, N2O is second only to molecular ... -
Structure Determination of Viscotoxin A1, Tendamistat and Tri Peptidyl peptidase-I
(2008-10-22)The current work reports the methods used to elucidate crystal structures of the target proteins using experimental phasing as well as their structure analysis.Viscotoxins belong to the ... -
Struktur-Funtionsbeziehung in den spleißosomalen Proteinen des U4/U6•U5 tri-snRNP
(2007-01-29)Subject of this thesis is the splicesosmal U5-particle. The functional relationship of the proteins is investigated by means of limited proteolysis and spectroscopy. Due to the splicesosome's ...