Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Engel, Wolfgang Prof. Dr."
Now showing items 1-20 of 49
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Analysis of coiled coil domain containing 33 protein (CCDC33) and determination of infertility causes in mutant mouse line with the deletion of six germ cell-specific genes
(2013-02-27)Since most cases of male infertility remain idiopathic, analysis of the mechanism in which genes are involved in spermatogenesis control might help to better understand the reasons. This thesis consists of 2 parts concerning ... -
Cellular and Biochemical Analysis of an Outer Dense Fiber Protein 2 (Odf2) Variant and the Endogenous Odf2 / Cenexin in Functional Approaches
(2009-02-11)The genome of a somatic cell is duplicated once every cell - cycle. The centrosome as well as the cytoskeleton plays central roles in orchestrating cell cycle progression and its proper ... -
Charakterisierung von Leupaxin und seiner Interaktionspartner in Karzinomzellen
(2011-02-23)Leupaxin (LPXN) is identified as a protein enhancing the growth of existing TRAMP-tumours and metastasis. Various pathways give evidence of this effect. The overexpression of LPXN in Prostate ... -
Comparative Analysis of Embryonic Stem Cells and Multipotent Adult Germline Stem Cells at the Level of Transcriptome and Proteome
(2011-04-01)Pluripotency of different stem cell types is a complex biological state which allows the cells to continuously proliferate (self-renewal) but also primes them for differentiation into all ... -
Creation and establishment of transgenic mouse models for for Mecp2 gene, causing Rett syndrome
(2007-05-08)The MeCP2 protein is a transcriptional repressor binding to methylated cytosines and modifying the chromatin structure. Mecp2 gene was eventually found to be the cause of 95% of Rett Syndrome cases. In spite of its ubiquitous ... -
Differentiation of Flk-1 positive multipotent adult germline stem cells into endothelial cells in vitro and in vivo
(2011-03-08)Multipotent adult germline stem cells (maGSCs) offer a novel route to cell-based therapy without immune rejection and ethical limitations. The present study showed the generation and expansion ... -
Effect of radiation on hepatic fat metabolism in rat and mouse: A role of radiation-induced TNF-α in the regulation of FAT/CD36
(2015-08-13)Radiotherapy is an important method to treat tumors. The positive effects of irradiation on tumoral tissue are thought to be due to the damage of the DNA of tumor cells and the damage of tumor vessels. Radiation as single ... -
Elucidation of Theg Gene Role in Spermatogenesis and Characterisation of a Novel Spontaneous Mutation Named “nax” in Mouse
(2003-02-11)In the present study, a differentially expressed gene, named Theg, expressed specifically in spermatids, is characterised. Its expression is up regulated by some unknown factor/s from Sertoli ... -
Expression and functional analyses of murine Pelota (Pelo) gene
(2007-04-25)In the present study, we have studied the expression pattern of Pelo at the protein level with the help of polyclonal anti-Pelo antibody and generation of conditional inactivation, which ... -
Expression and functional analysis of <i>Tex18</i> and <i>Stra8</i> genes in male germ cells
(2005-11-25)In the present study expression and functional analysis of two testis specific genes, namely Tex18 and Stra8 was performed.RT-PCR, made for the expression analysis of Tex18 gene showed it ... -
Expression and Functional Analysis of the Fas-Associated Factor1 (Faf1) Gene
(2007-04-27)Janchiv, Khulan: Expression and Functional Analysis of the Fas-Associated Factor1 (Faf1) Gene Key words: Faf1, VCP, UBA, UBX, TUNEL Dissertation zur Erlangung des Doktortitels, angenommen ... -
Expression and functional analysis of the germ cell specific genes ADAM 27 and Testase 2
(2004-02-12)In the present study two members of the ADAM family of proteins, murine ADAM 27 and Testase 2, were characterized. Both genes are expressed specifically in the testicular germ cells and therefore are postulated to be ... -
Functional Analysis of Insl5 and Insl6 Genes and Verification of Interactions between Pelota and its Putative Interacting Proteins.
(2009-11-27)The aims of the study were to determinate expression and function of two members of insulin like family, namely Insl5 and Insl6 and to verify the interactions between PELO and its putative ... -
Functional Analysis of the Dynein Light Chain Genes, <i>Dnali1</i> and <i>Tcte3</i>
(2006-02-01)In the present study, the function of two murine genes, Dnali1 and Tcte3 were investigated. Murine Dnali1 gene is a homologue of Chlamydomonas p28 and belongs to the family of inner arm ... -
Funktionelle Analyse des murinen Foxq1 Gens und die Charakterisierung magenspezifischer Gene
(2007-11-09)This work clearly demonstrates an involvement of Foxq1 in gastric acid secretion. Our results let us suggest, that Foxq1 takes part in the organisation of tubulovesicle transport or the ... -
Funktionelle Analyse des murinen Sall4-Gens
(2007-01-02)Mutations in human SALL4 gene cause Okihiro syndrome, an autosomal dominant disorder characterised by radial ray abnormalities and Duane anomaly and some other anal, renal, cardiac, ear, ... -
Funktionelle Analyse von MHC-Klasse-I-Genen der Rhesusaffen (<i>Macaca mulatta</i>)
(2008-09-01)This thesis focuses on the structure and function of rhesus macaque (Macaca mulatta, Mamu) major histocompatibility complex (MHC) class I genes. As the cellular immune response is at least ... -
Funktionelle Untersuchungen zum PTPN11-Genprodukt SHP2 und zu PTPN11 Mutanten, die dem Noonan-Syndrom zugrunde liegen
(2006-04-04)Noonan Syndrome (NS) [OMIM 163950] is an autosomal dominant disorder characterized by short stature, facial dismorphism, webbed neck, heart defects (most commonly pulmonic stenosis and ... -
Funtional Analysis of the Murine Genes, MOCS1 and Sox15
(2003-08-06)In this work, function of the murine genes, MOCS1 and Sox15 were investigated. Human molybdenum cofactor deficiency is a rare and devastating autosomal-recessive disease for which no therapy ... -
Genetic and functional characterisation of killer cell immunoglobulin like receptors (KIR) of rhesus macaques (Macaca mulatta)
(2011-02-24)This PhD thesis reports the characterisation of the genetic diversity of killer cell immunoglobulin like receptors (KIR) as well as interactions between KIR and MHC class I molecules in the ...