Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Figura, Kurt von Prof. Dr. Dr. h.c."
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Adenovirus-mediated gene transfer of FK506-binding proteins FKBP12.6 and FKBP12 in failing and non-failing rabbit ventricular myocytes
(2004-09-27)The FK506-binding proteins (FKBPs) FKBP12 and FKBP12.6 influence the Ca2+-release from the sarcoplasmic reticulum (SR) in skeletal and heart muscle, respectively, via regulation of the SR ... -
Characterisation of the Early Endosomal SNARE Complex
(2005-11-23)SNARE proteins are crucial factors in membrane fusion. These membrane proteins assemble to four-helix coiled-coils consisting of four SNARE helices: Qa, Qb, Qc and R, thereby fusing opposing ... -
Characterisation of Vti1b and Vti1a proteins and generation of knock-out mice.
(2002-07-09)Genomic DNA for Vti1b and Vti1a was isolated and the chromosomal regions characterised. Using targeted gene disruption mouse mutants lacking Vti1b constitutively were generated. It was shown ... -
Charakterisierung der Eaf 1-Funktion für die Biogenese der Aminopeptidase 1
(2008-11-10)In Saccharomyces cerevisiae the leucine exopeptidase aminopeptidase 1 (Ape1) is synthesized as a cytosolic precursor. After oligomerisation to a homododecameric complex the enzyme gets ... -
Charakterisierung der endosomalen Qb-SNAREs Vti1a und Vti1b
(2005-08-05)SNARE proteins play an important role as mediators of membrane fusion in the intracellular membrane transport. The goal of this thesis was to enlighten the mechanism of intracellular ... -
Charakterisierung Subtyp-spezifischer Autophagieproteine
(2009-06-15)Macroautophagy is a starvation-induced protein degradation pathway that nonselectively delivers cytosolic material and organelles to the vacuole (lysosome) for degradation. The Cvt-pathway ... -
Charakterisierung von SNARE-Proteinen in der Hefe Saccharomyces cerevisiae
(2003-05-14)SNARE proteins are involved in the fusion of transport vesicles with target membranes in all eukaryotes and form complexes in which 3 Q-SNAREs interact with one R-SNARE. In the first part ... -
Congenital Disorder of Glycosylation (CDG) - Ih
(2003-04-17)Die "Congenital Disorders of Glycosylation (CDG)" beschreiben eine schnell wachsende Gruppe von multisystemischen Erberkrankungen, die durch Mutationen in für die Biosynthese von Glykoproteinen ... -
Congenital Disorder of Glycosylation (CDG)-IIc: Eine retrovirale Expressionsklonierung identifiziert das CDG-IIc Syndrom (Leukozyten Adhäsionsdefekt II) als eine GDP-Fukose Transporter Defizienz
(2001-07-23)N-glycosylation is the most common modification of secretory and membrane-bound proteins in eukaryotic cells. In the last few years N-glycosylation obtained increased biomedical relevance ... -
Congenital Disorders of Glycosylation IIj (CDG-IIj): Identifizierung eines Defekts der COG6-Untereinheit des Conserved Oligomeric Golgi-Komplexes
(2010-09-16)`Congenital Disorders of Glycosylation` (CDG) are a rapidly expanding group of so far 23 autosomal recessive multisystemic disorders associated with deficiencies in the biosynthesis of ... -
Etablierung und Analyse von 'knock-out' Mausmodellen der σ1 Untereinheiten des AP 1 Komplexes
(2009-02-10)The multimeric adaptor protein complex 1 (AP-1) is essential for clathrin coated vesicle assembley mediating protein sorting between the trans-Golgi network (TGN) and the endosomal compartment. ... -
Functional characterization of the human renal organic anion transporter 3 (hOAT3) and comparison to hOAT1
(2004-06-01)Renal secretion of organic anions is critically dependent on their basolateral uptake against the electrochemical gradient. Due to their localization, two transporters are likely involved, ... -
Funktionelle Analyse von Isoformen der CAPS-Proteinfamilie
(2001-06-13)Endocrine, neural and exocrine cells posses a regulatory secretion pathway by which hormones, neurotranmittes and enzymes are released. This exocytosis process requires calcium, ATP and ... -
Genetic analysis of stoned B/stonin 2 function in vivo
(2005-07-04)Clathrin-mediated endocytosis at presynaptic nerve terminals is a regulated process tightly coupled to the exocytotic fusion event that requires clathrin, dynamin, AP2 as well as synaptotagmin ... -
Identification of a new factor essential for vacuolar aminopeptidase I activity.
(2004-12-08)The Saccharomyces cerevisiae vacuolar aminopeptidase I, Ape1p, is transported from the cytoplasm to the vacuole by constitutive autophagocytosis. Ape1p is synthesized as a proform with a ... -
Identifikation und immunologische Charakterisierung von MHC-Klasse-II-Peptidepitopen in humanen Leukämie- und Lymphom-assoziierten Antigenen
(2006-11-27)CD4+ T cells play important roles in antitumor responses through several different mechanisms. Ultimately, they provide crucial help in the induction and maintenance of CTL responses. ... -
Identifizierung der für die Agonisten-induzierte Phosphorylierung und Internalisierung relevanten Serine und Threonine in der C-terminalen Domäne des humanen Prostaglandin E2 Rezeptors, Subtyp EP4
(2003-08-18)The prostanoid receptors belong to the family of G protein-coupled receptors with seven transmembrane domains. Four different subtypes have been identified for prostaglandin E2 (PGE2). The ... -
Identifizierung und molekulare Charakterisierung des lysosomalen Matrixproteins Serincarboxypeptidase 1
(2008-07-30)The lysosomal matrix contains more than 50 hydrolytic enzymes that function in the degradation of macromolecules like polysaccharides, proteins, nucleic acids and lipids. Apart from their ... -
Insulin-Like Growth Factor Binding Protein-6: Posttranslational modifications and sorting in polarized MDCK cells
(2002-07-02)The insulin-like growth factors (IGFs) promote proliferation, and differentiation of a variety of cell types. The IGF availability and interactions with specific cell surface IGF-receptors ... -
Isolation and characterization of Saccharomyces cerevisiae mutants for vacuolar import and autophagocytosis
(2001-11-01)The yeast vacuolar protein aminopeptidase 1 (Apelp) is synthesised as a cytosolic procursor that is transported to the vacuole via the cytoplasm to vacuole trnasport (Cvt) pathway. The ...