Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Fritz, Hans-Joachim Prof. Dr."
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Aktivität endogener Retroviren in Tumorgeweben von Primaten
(2009-09-14)The human endogenous retroviruses of the family K (HERV-K) is an evolutionary young group of retroviral sequences. In comparison with other endogenous retroviruses, some HERV-K proviruses ... -
Analyse des Transkriptionsfaktors TGA2.1 aus Nicotiana tabacum
(2002-04-02)The thesis explores the possible function of the plant transcription factor TGA2.1. For this purpose genetically modified plants were generated in which a) TGA2.1 was ectopically overexpressed ... -
Analysen zu TRIM-Genen in Primaten
(2009-04-16)In this work, the evolution of TRIM genes with identical domain structure as the antiviral TRIM5a was studied. The analysed TRIM genes form two clusters on chromosome 6 and 11 (MHC and 11p15 ... -
Analysis of two kinetically distinct components of transmitter release at a fast synapse of the mammalian central nervous system
(2006-01-06)Two kinetically distinct components of transmitter release have been observed in Ca2+ uncaging experiments at a CNS synapse in rats, and both release components showed a steep dependence ... -
Characterization of the 95 kDa sperm adhesion protein
(2004-03-04)During the early stages of fertilisation, the interaction between the spermatozoa and the oocyte involves complex mechanism. The events of gamete recognition and binding triggers signal ... -
Charakterisierung der angeborenen Immunantwort in SIV-infizierten Rhesusaffen
(2010-01-28)Members of the APOBEC protein family of deaminases like A3G and A3F are components of the innate immunity capable to inhibit the replication of HIV in vitro. Their ability to influence viral ... -
Charakterisierung der bradyzoitspezifisch exprimierten P-Typ Plasmamembran ATPase TgPMA1 in <i>Toxoplasma</i> <i>gondii</i>
(2003-09-02)Toxoplasma gondii is an obligate intracellular parasite that causes persistent infections in a broad range of warm-blooded vertebrates, including humans. A stage differentiation ... -
Charakterisierung des 5-HT<sub>3B</sub>-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus
(2012-01-24)5-HT3B is a subunit of the serotonin receptor type 3 (5-HT3), which is an ion channel of the cys-loop receptor family. The gene HTR3B encodes for 5-HT3B. The polymorphism ... -
Charakterisierung eines neuen Proteins, Mapl-1 und seine Rolle in der Regulation der Pax-6 Funktion.
(2002-01-22)Pax proteins comprise a family of highly conserved transcriptional regulators that hold essential roles during embryonic development and organogenesis. The structural motif common to all ... -
Charakterisierung mukosaler Immunantworten im SIV-Makaken-Modell für AIDS
(2010-01-07)The massive damage of mucosal tissue as a consequence of infection as well as the sexual transmission of HIV via mucosa-associated tissue requires a better knowledge about these organs. The comparative flow-cytometric ... -
Charakterisierung zellulärer Immunantworten von mit SIV immunisierten und infizierten Makaken
(2007-11-26)The infection with HIV and the resulting AIDS-disease are a global challenge for mankind. The infection of macaques with simian immunodeficiency virus (SIV) is the most important animal ... -
Determination of the Structure of the Spliceosomal U6 snRNP from Yeast, <i>Saccharomyces cerevisiae</i>
(2007-08-09)The U6 small nuclear RNA (snRNA) undergoes major conformational changes during the assembly of the spliceosome and catalysis of splicing. It associates with the specific protein Prp24p, ... -
Efficacy of enzyme replacement therapy in α-manosidosis mice
(2006-08-11)The Lysosomal Storage Disorders (LSD) are a group of about 50 diseases caused by genetic defects that affect one or more of the lysosomal hydrolases. The defect results in the accumulation ... -
Einfluss der Helix 1 und des β-Faltblattes auf die Aggregation des Prionproteins und seine Amyloidstruktur
(2007-02-07)Prion diseases are caused by the aggregation of the native α-helical prion protein PrPC into its pathological β-sheet-rich isoform PrPSc. In current models of PrPSc, helix1 is assumed to ... -
Generation of Endoplasmic Reticulum Protein 28 (ERp28) Knock Out Mice, and Structural and Functional Analysis of its Drosophila Homologue, Wind
(2004-02-16)My thesis work includes two parts: firstly, generation of a knock out mouse of a gene, ERp28, which encodes a putative endoplasmic reticulum chaperone protein and secondly, the structural ... -
Identification and Functional Characterization of unc5A during Neocortical Regionalization
(2008-04-15)During the evolution of mammalian species, the cerebral neocortex acquired improved sensory, learning, and decision-making activities in parallel to its structural regionalization for specific functions. Each of these ... -
Identification of a new factor essential for vacuolar aminopeptidase I activity.
(2004-12-08)The Saccharomyces cerevisiae vacuolar aminopeptidase I, Ape1p, is transported from the cytoplasm to the vacuole by constitutive autophagocytosis. Ape1p is synthesized as a proform with a ... -
Identifikation und funktionelle Charakterisierung von Effektorproteinen des Typ III Sekretionssystems von Chlamydophila pneumoniae
(2009-09-08)Chlamydophila pneumoniae causes atypical pneumoniae and is also discussed as a risk factor for a wide range of chronic diseases like chronic obstructive pulmonary disease or atherosklerosis. ... -
Identifizierung und Charakterisierung von Genen für die Entwicklung des cerebralen Cortex
(2005-02-01)In order to identify new genes showing a regionalized expression in the E16.5 cerebral cortex a microarray expression analysis with 5 different cortex tissues was performed. After computational ... -
Investigation of Protein-protein Interactions within the Human Spliceosomal U4/U6.U5 tri-snRNP Particle
(2005-08-08)Two-hybrid data allowed me to define the regions through which proteins 220K, 200K, and 116K interact with each other. These regions include the N terminal and C-terminal domains of protein ...