Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Göpfert, Martin Prof. Dr."
Now showing items 1-20 of 26
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A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia
(2012-12-07)Summary A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia Schizophrenia (SZ) is as severe and phenotypically as well ... -
Analyses of improved long term memory in SHARP1 and SHARP2 double knockout mice
(2015-09-15)The transition of recent experiences into stable and remote memory traces is an important task that mainly occurs during sleep. Sleep-associated consolidation of remote long-term memory is based on cortical networks that ... -
Analysis of ether-à-go-go potassium channel (Eag1) splice variants in melanoma cells
(2011-05-03)The human ether-à-go-go potassium channel (hEag1) can be detected in adult brain and in both, tumor cell lines and primary tumors. The physiological function of this channel in the brain ... -
Behavioual Adaptations to Light Deprivation
(2019-03-20)Similar to most non-sedentary animals, Drosophila shows a wide range of visually guided behaviours and their functionality is crucial for survival. Previous studies showed that visual impairment significantly reduced the ... -
Biotechnological approaches to fight fruit flies of agricultural importance
(2012-10-08)Tephritid fruit flies destroy fruits and vegetables, causing tremendous economic losses and bringing a barrier to trade in fruits, vegetables and their associated products. The Sterile Insect Technique (SIT), a target-specific ... -
Candidate mechanosensitive transduction channels in Drosophila melanogaster
(2011-06-15)Gravity sensing and hearing in Drosophila melanogaster rely on Johnston's Organ (JO), a chordotonal stretch-receptor organ consisting of ca. 500 mechanosensory neurons residing in the 2nd ... -
Characterization of protein complexes associated with TRP channels in the context of nociception
(2017-12-05)The transient receptor potential A1 (TRPA1) channel is essential for vertebrate pain. TRPA1 plays a fundamental role as a primary detector of noxious stimuli of physical and chemical nature, and is critically involved in ... -
Charakterisierung und experimentelle Therapien eines neuen Mausmodells für das Rett Syndrom
(2015-11-20)Rett syndrome is one of the most frequent genetic causes of mental retardation of females. To date still no treatment exists for this disease, although genetic approaches in mice showed that Rett syndrome is treatable, at ... -
Chromophore-independent roles of Drosophila opsin apoproteins and visual cycle components
(2019-02-13)Visual rhodopsins consist of opsin protein moieties that are covalently bound to 11-cis-retinal, the visual chromophore that is derived from vitamin A. In Drosophila, the visual opsin genes Rh5 and Rh6 were reported to be ... -
Der Einfluss von Neuregulin-1 auf Erkrankungen des peripheren Nervensystems
(2014-07-08)A duplication of the gene encoding the peripheral myelin protein 22kDa (PMP22) underlies the commonest inherited neuropathy, Charcot Marie Tooth disease 1A (CMT1A). Although demyelination is a characteristic disease feature, ... -
Encoding, coordination, and decision making in the primate fronto-parietal grasping network
(2017-09-22)The processes taking place in our brain allow us to flexibly interact with our surrounding based on our internal demands. This requires perceptual information processing up to the generation of movements taking place in ... -
Functional Analysis of Two Major Sperm Tail Proteins Identifies ODF1 as Being Essential for the Tight Linkage of the Sperm Head to the Tail via SPAG4 and ODF2 as A Component of the β-catenin Destruction Complex
(2015-04-02)In the mammalian sperm tail, the outer dense fibers (ODFs) are accessory fibers accompanying the axonemal tubuli doublets on their outer site. The ODFs are composed of at least 14 polypeptides of which only a few have been ... -
Funktionelle Analyse des Transkriptionsfaktors Uncx4.1 im murinen Mittelhirn
(2012-05-18)The development of the brain is a complex process, which involves a lot of finely regulated processes. The best known disease which is associated with the midbrain is morbus parkinson. In the last years a lot of effort was ... -
Glutamate receptors potentiate single K-ATP channels through intracellular ATP changes
(2013-12-20)Rett Syndrome (RTT) is a neurodevelopmental disorder caused primarily by mutations in a Mecp2 gene and exclusively affects females. RTT is one of the prevalent developmental disorders with a high frequency of occurrence ... -
Identification and Characterization of Deafness Genes in Drosophila melanogaster
(2011-02-08)The antennal auditory organ of Drosophila, Johnston s organ (JO), provides a valuable system to study hearing. JO neurons and hair cells of mammals are developmentally specified via homologous ... -
Identification and Characterization of Protein Complexes Involved in Different Pain States in Vertebrates
(2019-02-28)Chronic pain imposes substantial challenges to medical practice as the treatment options for its clinically relevant manifestations are limited. Owing to lack of knowledge about the exact molecular mechanism underlying ... -
Modulation of the ROCK pathway in models of Parkinson´s disease
(2015-12-09)The cure of neurodegenerative diseases is one of the main goals in today’s neuroscience research. One of the main obstacles is the delayed diagnostics in relation to molecular pathology. In Parkinson’s disease (PD), several ... -
Molecular Mechanisms of Frequency Discrimination in the Drosophila Ear
(2023-01-24)Since the first confirmed evidence of potassium ions crossing the membrane to the first cloned and identified potassium channel from Drosophila melanogaster, the studies of potassium channels have extensively broadened our ... -
Molecular Physiology of the Ribbon Synapse
(2010-07-16)Hearing relies on Ca2+ influx-triggered exocytosis in cochlear inner hair cells (IHCs). In this study, we examined the regulation of IHC Ca2+ channels by the CaV(beta)2 Ca2+ channel subunit ... -
Molecular role of PMP22 in CMT1A
(2021-07-02)Myelinating Schwann cells wrap around peripheral axons and allow fast neural transmission. Peripheral myelin protein of 22 kDa (PMP22) is a transmembrane protein strongly expressed in Schwann cells. Alterations in PMP22 ...