Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Gottschalk, Gerhard Prof. Dr."
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Amino Acid Biosynthesis and the COP9 Signalosome in Aspergillus nidulans
(2003-01-30)The filamentous fungus Aspergillus nidulans represents an eukaryotic model system versatile in metabolism and developmental properties. This work focuses on the impact of modified enzyme ... -
Biosynthesis of Aromatic Amino Acids in Yeast and Aspergillus
(2001-02-22)Chorismate mutases (E.C. 5.4.99.5) catalyse the Claisen rearrangement of chorismic acid to prephenate, the first reaction of the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis. Within this ... -
Characterisation of Vti1b and Vti1a proteins and generation of knock-out mice.
(2002-07-09)Genomic DNA for Vti1b and Vti1a was isolated and the chromosomal regions characterised. Using targeted gene disruption mouse mutants lacking Vti1b constitutively were generated. It was shown ... -
Charakterisierung der endosomalen Qb-SNAREs Vti1a und Vti1b
(2005-08-05)SNARE proteins play an important role as mediators of membrane fusion in the intracellular membrane transport. The goal of this thesis was to enlighten the mechanism of intracellular ... -
Charakterisierung und Kristallisation der Elektronen-einspeisenden Module der F<sub>420</sub>H<sub>2</sub>-Dehydrogenase
(2004-07-28)The F420H2: quinone oxidoreductase from the hyperthermophilic sulfate reducing archaeon Archaeoglobus fulgidus and the F420H2: phenazine oxidoreductase from the methanogenic ... -
Charakterisierung und Nutzung der mikrobiellen Diversität extremer Habitate der Kamtschatka-Region
(2009-01-06)The Kamchatka Peninsula, located in the northeast of Russia is known for its variety of volcanic areas. Samples from these environments are excellent sources for extremophilic microorganisms ... -
Charakterisierung von SNARE-Proteinen in der Hefe Saccharomyces cerevisiae
(2003-05-14)SNARE proteins are involved in the fusion of transport vesicles with target membranes in all eukaryotes and form complexes in which 3 Q-SNAREs interact with one R-SNARE. In the first part ... -
Congenital Disorder of Glycosylation (CDG) - Ih
(2003-04-17)Die "Congenital Disorders of Glycosylation (CDG)" beschreiben eine schnell wachsende Gruppe von multisystemischen Erberkrankungen, die durch Mutationen in für die Biosynthese von Glykoproteinen ... -
Congenital Disorder of Glycosylation (CDG)-IIc: Eine retrovirale Expressionsklonierung identifiziert das CDG-IIc Syndrom (Leukozyten Adhäsionsdefekt II) als eine GDP-Fukose Transporter Defizienz
(2001-07-23)N-glycosylation is the most common modification of secretory and membrane-bound proteins in eukaryotic cells. In the last few years N-glycosylation obtained increased biomedical relevance ... -
Entschlüsselung des Genoms von Gluconobacter oxydans 621H - einem Bakterium von industriellem Interesse
(2004-09-08)Gluconobacter oxydans belongs to the group of acetic acid bacteria and is characterized by the incomplete oxidation of a wide range of carbohydrates and alcohols. Because this ... -
Functional analysis of the GlnK1 protein of Methanosarcina mazei strain Gö1: Aspects of nitrogen regulation
(2005-09-26)PII-proteins like GlnB and GlnK are ubiquitous distributed small regulator proteins that play a key role in regulation of nitrogen metabolism by sensing and signalling the intracellular ... -
Funktionelle Genomanalyse des Purinverwerters Clostridium acidurici 9a
(2013-02-20)Clostridium acidurici is an anaerobic, homoacetogenic bacterium, which is able to use purines such as uric acid as sole carbon, nitrogen, and energy source. Together with the two other known purinolytic clostridia C. ... -
Genom- und Transkriptionsanalyse von <i>Bacillus licheniformis</i> DSM13 - einem Organismus mit großem industriellem Potential
(2006-01-17)The Gram-positive soil bacterium Bacillus licheniformis is an organism of high industrial relevance. It is used in technical fermentations to produce large amounts of exoenzymes like proteases ... -
Genome Sequence Analysis and Characterization of Recombinant Enzymes from the Thermoacidophilic Archaeon Picrophilus torridus
(2004-09-16)Picrophilus torridus is a thermo- and acidophilic archaeon which grows optimally at 60°C and pH 0.7 and thus represents the most acidophilic organism known so far. In the frame of ... -
Genomweite Transkriptionsanalyse von Methanosarcina mazei Gö1
(2003-11-04)Computer programs have been developed in the course of this project that made it possible to generate DNA-Microarray-Chips that represent the whole genome of Methanosarcina mazei ... -
Identification of a new factor essential for vacuolar aminopeptidase I activity.
(2004-12-08)The Saccharomyces cerevisiae vacuolar aminopeptidase I, Ape1p, is transported from the cytoplasm to the vacuole by constitutive autophagocytosis. Ape1p is synthesized as a proform with a ... -
Identifizierung von Chitinasen mit fungizider Wirkung
(2004-02-11)Chitin is an linear unsoluble polymer consisting out of β-1,4-N-acetyl-D-glucosamin-units. This Polymer is the second most abundant polymer in nature and is a structural component of ... -
Insulin-Like Growth Factor Binding Protein-6: Posttranslational modifications and sorting in polarized MDCK cells
(2002-07-02)The insulin-like growth factors (IGFs) promote proliferation, and differentiation of a variety of cell types. The IGF availability and interactions with specific cell surface IGF-receptors ... -
Konstruktion und Durchmusterung von Metagenombanken: Identifizierung und Charakterisierung von Genen und Genprodukten von am Polyol-Stoffwechsel beteiligten Oxidoreduktasen und Coenzym B12-abhängigen Dehydratasen
(2004-01-21)A new way to exploit the metabolic and genetic diversity of microorganisms is the construction of DNA libraries directly from environmental samples. To isolate new genes encoding coenzyme ... -
Metagenomic Analyses of Glacier Ice
(2009-06-15)The largest part of the Earth s microbial biomass is stored in cold environments, which represent almost untapped reservoirs of novel species, processes, and genes. In this study, the ...