Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Groß, Uwe Prof. Dr."
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Die Bedeutung von BRCA1-assoziiertem Protein in der Entwicklung der lastinduzierten Myokardhypertrophie
(2009-02-17)Mitogen activated protein kinase (MAPK) pathways are regulating important cellular processes such as growth, differentiation, mitosis and apoptosis and are highly relevant for cardiac ... -
Biochemical Characterization of <i>Toxoplasma gondii</i> Type II NADH Dehydrogenases - Physiological Impact on Mitochondrial Functions and Energy Metabolism
(2010-03-09)The single subunit mitochondrial type II NADH dehydrogenases (NDH2s) in apicomplexan parasites have been considered as potential drug targets due to the absence in mammalian cells. Toxoplasma ... -
Characterisation of the cell wall protein Pga29p in the human pathogenic fungus <i>Candida albicans</i>
(2009-02-17)Candida albicans is an opportunistic fungal pathogen that is responsible for most of the Candida infections in humans. It can cause superficial infections on the mucosa, nails or skin and ... -
Characterisation of the immune modulatory effect of wild type Rift Valley fever virus strains
(2010-11-12)Rift Valley fever Phlebovirus (RVFV) belongs to the Bunyaviridae family. It is transmitted by mosquitoes and infects a wide range of vertebrate hosts. In humans, infection can lead to fatal ... -
Characterization of genes differentially regulated after bile acid exposure in Campylobacter jejuni
(2019-08-23)In the past decades Campylobacter has raised as the main cause of bacterial gastrointestinal infection worldwide. Campylobacter causes gastrointestinal infection that can vary from asymptomatic, mild to a severe diarrhea. ... -
Characterization of the cell wall protein Ecm33 family in Candida glabrata
(2013-09-05)Candida glabrata is the second most frequent cause of local and systemic human candidiasis and infections with this species are difficult to treat because of frequent azole resistance. C. glabrata infections have high ... -
DNA methylation as a potential epigenetic driver of morphological development in Candida albicans
(2022-01-04)Candida albicans is a commensal yeast in the mammalian gut, but also has retained its virulence potential while co-evolving in mammalian species. As a perfectly adapted opportunist colonizing mucosal surfaces, it is also ... -
Effect of Radiation on Leukocytes Migration and Gene expression of Rat Liver Chemokines: In-vivo and In-vitro Studies
(2010-02-01)Liver damage is a serious clinical complication of gamma-irradiation. CXC- and CC-chemokines, known to attract inflammatory cells, play a role in transmigration process during inflammation. Chemokines are generated locally ... -
Effekte von Hypericin auf humane renale Karzinomzellen in vitro
(2010-06-08)Hypericin is an agent extracted from Hypericum plants. St. John s wort (Hypericum perforatum, L.) is the most common representative of this genus. Blooms and leaves of Hypericum plants are ... -
Der Einfluss mechanischer Last auf das Potential multipotenter adulter Keimbahnstammzellen zur kardialen Regeneration
(2011-02-23)In the present thesis murine multipotent adult germline stem cells (maGSCs) were analysed under different conditions in vivo and in vitro. It was shown in vivo that undifferentiated maGSCs ... -
Entwicklung von diagnostischen Methoden zum Nachweis von europäischen humanpathogenen Arboviren
(2014-10-17)A majority 50-70% of aseptic meningo-encephalitis cases is caused by unknown aetiological agents.
In the course of this work a cytometric bead array (CBA) for simultaneous detection of antibodies against ...
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Epidemiologische Untersuchungen zur Toxoplasmose und Identifizierung immunogener parasitärer Antigene
(2012-02-23)Toxoplasmosis is an infectious disease caused by the parasite Toxoplasma gondii. Whereas the infection proceeds in most cases asymptomatically in immunocompetent humans, a threat for the ... -
Genomweite Suche neuer Modulatoren der Signaltransduktion in kardialer Hypertrophie und Herzinsuffizienz
(2011-02-23)Activated through cytokines, growth factors and hormones the MAPK signaling pathway regulates cell response to environmental cues. The signaling cascade is involved in fundamental cellular ... -
Hemmung der Cytochrom c-induzierten Caspase-Aktivierung durch Toxoplasma gondii in vitro und in vivo:molekulare Mechanismen und parasitäre Effektormoleküle
(2012-11-22)Toxoplasma gondii is an obligate intracellular parasite and is able to infect almost all nucleated cells of humans and warm-blooded animals. Infection of immunocompetent individuals is mostly asymptomatic and leads to ... -
Human and mouse meniscus progenitor cells and their role in meniscus tissue regeneration
(2014-05-19)Osteoarthritis (OA) is a degenerative disease of hyaline cartilage. The cartilage is an avascular tissue, once damaged it is difficult to repair. Articular cartilage is responsible for the smooth, frictionless, and painless ... -
Identification and characterization of virulence associated factors of C. jejuni
(2010-11-25)Campylobacter jejuni, an important food-borne human bacterial pathogen in industrialized countries and in the developing world, the leading cause of bacterial diarrhoea. The infection may ... -
Identifikation und funktionelle Charakterisierung von Effektorproteinen des Typ III Sekretionssystems von Chlamydophila pneumoniae
(2009-09-08)Chlamydophila pneumoniae causes atypical pneumoniae and is also discussed as a risk factor for a wide range of chronic diseases like chronic obstructive pulmonary disease or atherosklerosis. ... -
Identifizierung infektionsrelevanter Antigene des Schimmelpilzes Aspergillus fumigatus sowie deren rekombinante Herstellung mit dem Ziel der Entwicklung eines Impfstoffes gegen die invasive Aspergillose
(2010-08-17)Aspergillus fumigatus is the main cause of invasive aspergillosis, which is more frequently diagnosed due to the ongoing use of immunosuppressive pharmaceuticals. Prior publications ... -
Identifizierung neuer Coregulatoren von SOX9 und RUNX2 in chondrogenen Progenitorzellen in der Osteoarthrose
(2015-06-23)Osteoarthritis is a degenerative disease of the joints. It is characterized by a successive destruction of the articular cartilage and surrounding structures. Osteoarthritis is the most common musculoskeletal joint disease ... -
Identifizierung schutzvermittelnder Antigene von Aspergillus fumigatus für eine Impfstoffentwicklung zur Verhütung invasiver Aspergillosen bei Leukämie-Patienten
(2015-01-23)A.fumigatus is the most common cause of invasive, usually fatal aspergillosis in severely immunocompromised patients. A natural resistance to the fungus is mediated by the innate immune system. Additionally, an acquired ...