Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Hardeland, Rüdiger Prof. Dr."
Now showing items 1-20 of 74
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Analyse und Expression der Komplementproteine Faktor H und Faktor I der Ratte
(2003-11-25)In this thesis the previously unknown complete coding cDNA-sequence of rat complement protein factor H (FH) was revealed. In addition to the identification of the coding sequence two short variants of rat factor H were ... -
Anaylse der RyREF2-Bindungsstelle im Promotor des procinen RyR1 Gens und Characterisierung des procinen FHL1-Gens
(2001-11-07)Not available. -
Aspekte der Translationskontrolle in der Drosophila-Spermatogenese: Charakterisierung regulatorischer Elemente
(2002-12-04)Protein-RNA interactions are essential in the control of translation during cell differentiation in many organisms. The goal of this work was to characterize such interaction during ... -
Bedeutung der Homöodomäne des Transkriptionsfaktors Pax6 für die Aktivierung des Glukagon-Gens durch Pax6
(2004-09-08)Pax6 is one of the essential transcription factors for activating glucagon gene expression and contains two DNA-binding domains, the paired domain and the homeodomain. In vitro, Pax6 binds ... -
Die Bedeutung der subzellulären CaMKIIδ-Überexpression auf den intrazellulären Ca2+-Stoffwechsel in Herzmuskelzellen
(2007-04-17)The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase. It is formed as a multimer consisting of 6 to 12 monomers. CaMKIIδ, the ... -
BEHAVIOURAL AND PHARMACOLOGICAL VALIDATION OF CHRONIC SOCIAL STRESS AS A MODEL OF DEPRESSIVE-LIKE SYMPTOMS IN RATS
(2006-06-22)In order to develop a model of chronic social stress in rats, in the first study the male Wistar rats were subjected to five weeks daily exposure to social defeat. This protocol resulted ... -
Characterization of foetal hepatic cells during rat liver development
(2006-11-06)During embryonic development the embryonic/foetal liver is the site where hepatogenesis and hematopoiesis take place. Hepatoblasts have been partly characterized in several previous studies. ... -
Charakterisierung der Proteinphosphatase 1E (PPM1E) - Lokalisierung und Trunkation in Gehirngewebe und Effekte auf neuronale Morphologie in primärer Neuronenkultur
(2010-11-26)Alzheimer s disease (AD) is a progressive neurodegenerative disorder, characterized by early deficits in learning and memory with eventual loss of higher cognitive functions. Although ... -
Charakterisierung von stressregulierten Genen als potentielle Modulatoren von Lernen und Angst
(2003-01-15)Our laboratory has recently demonstrated that 1 h of stressful immobilization of Balb/c mice result in an enhanced learning if animals are trained 3 later in the fear conditioning paradigm. Furthermore it was shown that ... -
Cloning and characterization of organic anion systems in the adrenal cortex and their role in steroid release
(2001-06-06)The adrenal steroid hormones have a central role in maintaining homeostasis, as they have influence on almost every physiological process. Their movement across the cell membrane is still ... -
DIFFERENTIAL GENE EXPRESSION DURING ISCHEMIA AND REPERFUSION IN AN EXTRACORPOREAL SMALL BOWEL PERFUSION MODEL IN SWINE
(2002-12-04)In a perfusion model using isolated small intestine of the pig, a strong inflammatory reaction with cytokine release and induction of corresponding mRNA expression was shown during reperfusion ... -
Differentielle Expression und Funktion eines glialen Kaliumkanals (K<sub>ir</sub>4.1, KCNJ10) im Rückenmark und Bedeutung in einem neurodegenerativen Krankheitsmodell
(2008-07-10)In the last decade it became more and more obvious, that inwardly-rectifying potassium channels (Kir), beside their classical role in establishing and maintaining the resting membrane ... -
Differentielle Genexpressionsanalyse aktivierter Endothelzellen
(2001-08-28)Differential Display-PCR (DD) is a mRNA-fingerprint technique to identify differentially expressed genes by comparing displayed sets of randomized amplified cDNA. For this, an elaborated ... -
Downstream targets of transcription factor Pax6 in cortical development
(2008-04-22)Pax6 is a transcription factor with key functional roles in patterning and arealization of the cortex. We studied regulation of gene expression in Pax6 mutants through microarray analysis. This allowed us to focus on ... -
Einfluss der Helix 1 und des β-Faltblattes auf die Aggregation des Prionproteins und seine Amyloidstruktur
(2007-02-07)Prion diseases are caused by the aggregation of the native α-helical prion protein PrPC into its pathological β-sheet-rich isoform PrPSc. In current models of PrPSc, helix1 is assumed to ... -
Einschränkung hepatischer Abwehrreaktionen während einer Entzündung durch Prostaglandin E2 über Gs-Protein-gekoppelte Prostaglandin E2-Rezeptoren
(2002-07-05)The acute phase response is a complex reaction to injury and infection. It is initiated and maintained by cytokines, e. g. TNFalpha (tumor necrosis factor alpha) and interleukin-6 (IL-6). ... -
Eskalierendes Commitment und präferenzkonsistente Informationsbewertung
(2006-07-14)The PhD thesis offers a new explanation for escalation of commitment. Escalation of commitment is the tendency to persist in losing courses of action or to throw good money after bad. ... -
Expression der CRFR-Gene in Antwort auf Stress und Lernen
(2003-05-23)Learning can be defined as a process by which organisms alter and adapt their behavior to environmental stimuli thereby forming an inner representation of their world. One of the most ... -
Expression und Funktion von Caveolin bei glialen Zellen, insbesondere Oligodendrozyten
(2006-07-25)Caveolin-containing microdomains (CMD) are subdomains of the plasma membrane that contain high concentrations of sphingomyelin, glycosphingolipids and cholesterol. They are involved in ... -
Expressionsanalyse des humanen Histonsubtyps H1x
(2008-06-02)Nuclear eukaryotic DNA is organised as chromatin in conjunction with proteins. The basal structural organisation unit of chromatin is the nucleosome consisting of the nucleosome core particle, ...