Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Heinrich, Ralf Prof. Dr."
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A neuronal PIP3-dependent program of oligodendrocyte precursor recruitment and myelination
(2017-01-26)Evolution of myelin has enabled rapid impulse propagation and development of complex brain circuitry. However, the in vivo mechanisms that trigger and orchestrate proliferation of oligodendrocyte precursor cells (OPCs), ... -
A new rodent model of Parkinson s Disease based on neuron specific downregulation of glutathione production.
(2009-04-21)Parkinson s disease (PD) is characterized by a progressive degeneration of the nigrostriatal system. Only in few patients genetic mutations have been identified to cause disease onset, ... -
Amyloid-beta driven changes in transcriptome plasticity: From OMICS to Therapy
(2016-04-06)Alzheimer’s disease is characterized by a progressive cognitive decline coinciding with the formation of amyloid plaques and tau fibrils in the human brain. It is the most common form of dementia and the number of people ... -
Analyzing UNC-50/GMH1 dependent membrane trafficking in yeast and C. elegans
(2015-11-30)Although the basic principles of the intracellular trafficking of proteins and lipids within the secretory apparatus have been established, the precise regulation of molecular membrane transport events is still not well ... -
Anti-apoptotic and neuroprotective erythropoietin/CRLF3-signalling in insects and humans
(2022-06-14)The cytokine receptor like factor 3 (CRLF3) evolved together with the eumetazoan nervous system and is present in all major groups of Animalia. Based on sequence similarities, CRLF3 was assigned to the family of class 1 ... -
Anti-TGF-beta-Antikörper und Öffnung der Blut-Hirn-Schranke - Evaluation neuer Optionen zur Behandlung hochmaligner Gliome im Tiermodell
(2010-06-16)Malignant brain tumors are characterized by a very poor prognosis with current standard-of-care therapies. Even high dose chemotherapy and new experimental drugs have not improved the outcome ... -
Attention and Adaptation in Visual Motion Processing
(2007-11-20)This thesis contributes to the questions of how cognition and the history of the visual input influence the processing of sensory information in the brain. The main part of this work consists ... -
Attention shift and remapping across saccades
(2017-03-15)Humans and monkeys make two to three saccades per second on average when they are awake, and they are able to keep track of relevant visual stimuli while making saccadic eye-movements to scan a visual scene. Since the ... -
Behavioual Adaptations to Light Deprivation
(2019-03-20)Similar to most non-sedentary animals, Drosophila shows a wide range of visually guided behaviours and their functionality is crucial for survival. Previous studies showed that visual impairment significantly reduced the ... -
Bilateral processing of thermoreception in the olfactory system of larval Xenopus laevis
(2011-01-12)This study of the ventral olfactory bulb of larval Xenopus laevis shows for the first time the existence of a thermosensitive olfactory glomerulus. This thermosensitive olfactory glomerulus ... -
Bilaterale Koordination kommissuraler Interneurone im Mesothorakalganglion von Locusta migratoria migratorioides
(2009-03-26)Bilateral left-right-coordination of insect pairs of legs must involve commissural interneurons (CINs) which cross the midline of the segmental ganglion. This study describes two types ... -
Cell-penetrating peptide-enhanced delivery of heat shock proteins in models of neurodegeneration
(2008-04-30)The hallmark of Parkinson's disease (PD) is the loss of dopaminergic (DA) neurons in the substantia nigra (SN), the depletion of striatal dopamine levels, and the presence of intraneuronal proteinaceous cytoplasmatic ... -
Charakterisierung von Calcium-Transienten in Astrozyten der ventralen respiratorischen Gruppe
(2007-11-27)Astrocytes are described as one of the major cell population in the brain of mammals and show a special form of excitability, which is based on changes of intracellular Ca2+-concentrations. ... -
Development of Transgenic Sterile Insect Technique Strains for the Invasive Fruit Pest Drosophila suzukii
(2020-12-03)Globalization has contributed enormously to emergence and expansion of invasive pests. A recent example is the invasion in Europe and the USA by the cherry vinegar fly Drosophila suzukii. The pest has high potential to ... -
Effect of nitric oxide and inflammatory mediators on axonal transport
(2005-11-04)Increased production of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and reactive oxygen species by glia in the central nervous system (CNS) is a hallmark of a variety ... -
Efficacy of enzyme replacement therapy in α-manosidosis mice
(2006-08-11)The Lysosomal Storage Disorders (LSD) are a group of about 50 diseases caused by genetic defects that affect one or more of the lysosomal hydrolases. The defect results in the accumulation ... -
Erythropoietin-mediated neuroprotection in insects
(2016-08-30)The cytokine erythropoietin (Epo) initiates adaptive cellular responses to a variety of mechanical and physiological insults in various non-hematopoietic mammalian tissues including the nervous system. Previous studies on ... -
Expression and function of erythropoietin and its receptor in invertebrate nervous systems
(2010-02-08)This doctoral study provided substantial evidences for the presence of the EPO/EPOR signalling system in the CNS of invertebrates from different phyla (chapter 2) and demonstrated neuroprotective ... -
Functional characterization and molecular identification of neuroprotective receptors for erythropoietin-like ligands
(2019-12-19)The cytokine erythropoietin (Epo) regulates erythropoiesis but also protects mammalian neurons from apoptosis. However, receptors and transduction pathways involved in neuroprotection are only partially characterized. ... -
Funktion und die Signalübertragung der GABAB-Rezeptoren im respiratorischem Netzwerk der Maus
(2007-07-10)The present project investigated the novel aspects of the function and downstream signaling of GABAB receptors i the developing brainstem respiratory