Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Hoyer-Fender, Sigrid Prof. Dr."
Now showing items 1-20 of 46
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Analyse zur Rolle von pflanzlichen Wirkstoffen und Histondeacetylase-Inhibitoren auf Wachstumsfaktoren und deren Signalwege in Prostatakarzinomzellen
(2013-12-19)Prostate cancer (PCa) is the most frequently new diagnosed cancer entity and the third leading cause of cancer-related deaths of men in Germany. The options for therapy of PCa are restricted and most of them have strong ... -
Calreticulin in kidney function and disease: chronic low level of calreticulin impairs Ca2+ homeostasis leading to mitochondrial dysfunction and chronic renal injury
(2012-11-28)Chronic kidney disease (CKD) is becoming a major public health problem worldwide. The persistent progression of CKD is postulated to result from a self-perpetuating vicious cycle of events activated after initial injury. ... -
CEP72 represents a putative Oncogene that negatively regulates the mitotic Function of Brca1 and induces Chromosomal Instability
(2015-10-26)Proper progression through mitosis ensures the maintenance of whole chromosomal stability in a eukaryotic cell. Hence, failures during this tightly regulated process can lead to the perpetual mis-segregation of whole ... -
Charakterisierung der Sumoylierung von p35, dem Aktivator der Zyklin-abhängigen Kinase 5 (Cdk5), und der daraus resultierenden funktionellen Konsequenz
(2013-05-28)For the central nervous system development and neuron-specific functions, including neurite outgrowth as well as synaptic function and plasticity, cyclin-dependent kinase (Cdk) 5 has a central role. Cdk5 activity requires ... -
Charakterisierung von Leupaxin und seiner Interaktionspartner in Karzinomzellen
(2011-02-23)Leupaxin (LPXN) is identified as a protein enhancing the growth of existing TRAMP-tumours and metastasis. Various pathways give evidence of this effect. The overexpression of LPXN in Prostate ... -
Comparative Analysis of Embryonic Stem Cells and Multipotent Adult Germline Stem Cells at the Level of Transcriptome and Proteome
(2011-04-01)Pluripotency of different stem cell types is a complex biological state which allows the cells to continuously proliferate (self-renewal) but also primes them for differentiation into all ... -
Differentiation of Flk-1 positive multipotent adult germline stem cells into endothelial cells in vitro and in vivo
(2011-03-08)Multipotent adult germline stem cells (maGSCs) offer a novel route to cell-based therapy without immune rejection and ethical limitations. The present study showed the generation and expansion ... -
Effekte von Hypericin auf humane renale Karzinomzellen in vitro
(2010-06-08)Hypericin is an agent extracted from Hypericum plants. St. John s wort (Hypericum perforatum, L.) is the most common representative of this genus. Blooms and leaves of Hypericum plants are ... -
Einfluss von GnRH Analoga auf die Metastasierung humaner Mammakarzinomzellen in vitro und in vivo
(2010-12-08)Breast cancer is one of the tumor diseases with a very strong metastasis behavior, with the bone as one of the main target sites. Since 50 % of human breast cancers express GnRH receptors, ... -
Embryonic and foetal germ cell development in the marmoset monkey: comparative in situ and cell culture studies
(2018-11-12)Primordial germ cells (PGCs) are the precursors of sperm and egg cells. They arise early in mammalian embryonic development and have to translocate from their extraembryonic tissue of specification over a significant ... -
Expression and Functional Analysis of the Fas-Associated Factor1 (Faf1) Gene
(2007-04-27)Janchiv, Khulan: Expression and Functional Analysis of the Fas-Associated Factor1 (Faf1) Gene Key words: Faf1, VCP, UBA, UBX, TUNEL Dissertation zur Erlangung des Doktortitels, angenommen ... -
From stem cells to male germ cells: Experimental approaches for the in vitro generation of mouse and human spermatogonial stem cells
(2015-06-24)Currently different in vitro experimental approaches make use of the unique potential of pluripotent cells in order to produce functional sperm aiming at the establishment of new treatment opportunities for male infertility. ... -
Functional Analysis of Insl5 and Insl6 Genes and Verification of Interactions between Pelota and its Putative Interacting Proteins.
(2009-11-27)The aims of the study were to determinate expression and function of two members of insulin like family, namely Insl5 and Insl6 and to verify the interactions between PELO and its putative ... -
Functional Analysis of Two Major Sperm Tail Proteins Identifies ODF1 as Being Essential for the Tight Linkage of the Sperm Head to the Tail via SPAG4 and ODF2 as A Component of the β-catenin Destruction Complex
(2015-04-02)In the mammalian sperm tail, the outer dense fibers (ODFs) are accessory fibers accompanying the axonemal tubuli doublets on their outer site. The ODFs are composed of at least 14 polypeptides of which only a few have been ... -
Functional characterization of CDY family proteins and their role in recognition of the heterochromatic histone H3K9me3 modification
(2010-01-14)In the nucleus of eukaryotic cells the DNA is wrapped around octamers of histone proteins containing two H2A-H2B dimers and one (H3-H4)2 tetramer. This entity represents the basic repeating ... -
Funktionen und Interaktionen von Homöodomänenproteinen während der Entwicklung des Rückenmarks
(2006-12-13)The dorsal spinal cord consists of several types of interneurons which process and relay sensory information from the periphery. These dorsal interneurons are generated during two distinct ... -
Human and mouse meniscus progenitor cells and their role in meniscus tissue regeneration
(2014-05-19)Osteoarthritis (OA) is a degenerative disease of hyaline cartilage. The cartilage is an avascular tissue, once damaged it is difficult to repair. Articular cartilage is responsible for the smooth, frictionless, and painless ... -
Identification and Functional Characterization of Novel Genes Involved in Primary Neurogenesis in Xenopus laevis
(2002-07-16)The South African claw-toed frog, Xenopus laevis, is a good model to study neurogenesis in vertebrates. Early on, at the open neural plate stage, the territory of primary neurons is nicely ... -
Identifikation und funktionelle Charakterisierung von Effektorproteinen des Typ III Sekretionssystems von Chlamydophila pneumoniae
(2009-09-08)Chlamydophila pneumoniae causes atypical pneumoniae and is also discussed as a risk factor for a wide range of chronic diseases like chronic obstructive pulmonary disease or atherosklerosis. ... -
Identifizierung neuer Coregulatoren von SOX9 und RUNX2 in chondrogenen Progenitorzellen in der Osteoarthrose
(2015-06-23)Osteoarthritis is a degenerative disease of the joints. It is characterized by a successive destruction of the articular cartilage and surrounding structures. Osteoarthritis is the most common musculoskeletal joint disease ...