Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Jahn, Reinhard Prof. Dr."
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Analysis of the mechanisms of interaction of alpha-synuclein and membranes in cellular models of Parkinson´s Disease
(2018-12-04)Alpha-synuclein (aSyn) plays a crucial role in Parkinson’s disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions known as Lewy bodies. The physiological function ... -
Biochemistry and physiological role of otoferlin
(2011-11-24)In humans deafness is caused by environmental but also by genetic factors. Mutations in the gene encoding otoferlin are one genetic cause of deafness, leading to DFNB9 an autosomal recessive ... -
Biophysical Characterization of SNARE Complex Disassembly Catalyzed by NSF and alphaSNAP
(2008-09-17)SNAREs (SNAP receptors) are small membrane-bound proteins which are key mediators of intracellular membrane fusion. The actual fusion step is believed to occur through complex formation of ... -
Biophysikalische und thermodynamische Charakterisierung der neuronalen SNARE-Komplexbildung
(2008-07-16)Membrane fusion events are mediated by a set of conserved protein machinery, the SNARE proteins. SNARE proteins assemble into a very stable α-helical complex between two membranes. The ... -
Development of Viral Tools for CNS Gene Transfer: Adeno-Associated Viral Vectors in Gene Therapy of Parkinson's Disease
(2006-08-09)Gene transfer to the brain is a promising therapeutic strategy for a variety of neurodegenerative disorders including Parkinson s disease (PD). PD is characterized by a progressive degeneration of the nigrostriatal ... -
Differentielle Expression und Funktion eines glialen Kaliumkanals (K<sub>ir</sub>4.1, KCNJ10) im Rückenmark und Bedeutung in einem neurodegenerativen Krankheitsmodell
(2008-07-10)In the last decade it became more and more obvious, that inwardly-rectifying potassium channels (Kir), beside their classical role in establishing and maintaining the resting membrane ... -
Elektronenmikroskopische 3D Strukturbestimmung des Spleißosoms
(2005-08-15)In order to elucidate the conformational changes of the spliceosome that occur during its catalytic activation it is necessary to obtain high resolution 3D structures. The 3D structure of ... -
Elucidation of protein interactions in complex samples by protein-protein cross-linking of synaptosomes
(2019-08-23)Synapses are essential structures for inter-cellular communication in the central nervous system between neuronal cells. They form highly-specialized compartments that convert electrical to chemical signals, i.e. ... -
Epac-mediated modulation of neurotransmitter release from cultured hippocampal neurons
(2008-07-15)cAMP regulates secretory processes through both protein kinase A (PKA)-independent and PKA-dependent signaling pathways. However, their relative contributions to fast neurotransmission are ... -
Evolution of Bicoid-dependent hunchback Regulation in Diptera
(2006-12-20)An early segmentation gene of Drosophila melanogaster, hunchback, with an evolutionarily conserved function but diverging regulation was used as an entry point to explore the evolution of early ... -
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
(2006-09-18)During regulated exocytosis from neurons and neuroendocrine cells a rise in intracellular calcium concentration leads to the formation of the so-called core-complex, between the plasmalemmal ... -
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
(2006-09-18)During regulated exocytosis from neurons and neuroendocrine cells a rise in intracellular calcium concentration leads to the formation of the so-called core-complex, between the plasmalemmal ... -
Free energy calculations of protein-ligand complexes with computational molecular dynamics
(2008-11-07)The accurate calculation of binding free energies for protein-ligand complexes is a field of extensive research. The accuracy in such free energy calculations from atomic-level molecular ... -
Functional Studies of SNAP-25 using a knock-out and rescue approach
(2006-11-01)The neuronal SNARE complex, consisting of SNAP-25, synaptobrevin and syntaxin, is required for presynaptic exocytosis of neurotransmitter-filled vesicles during synaptic transmission. However ... -
Eine funktionelle Charakterisierung der frühendosomalen SNARE-Proteine
(2009-06-19)Most intracellular transport processes occur via budding and fusion of vesicles, where fusion is dependent on SNARE proteins. Fusion is preceded by docking, the close contact of vesicles ... -
Die Funktionelle Rolle der Palmitilierung des 5-HT 1A Rezeptor
(2005-04-08)In the present study, we verified that the mouse 5-hydroxytryptamine(1A) (5-HT(1A)) receptor is modified by palmitic acid, which is covalently attached to the protein through a thioester-type ... -
Genetic analysis of stoned B/stonin 2 function in vivo
(2005-07-04)Clathrin-mediated endocytosis at presynaptic nerve terminals is a regulated process tightly coupled to the exocytotic fusion event that requires clathrin, dynamin, AP2 as well as synaptotagmin ... -
High-resolution characterization of structural changes involved in prion diseases and dialysis-related amyloidosis
(2009-10-16)Protein aggregation is the cause of several human diseases such as diabetes mellitus type 2, Parkinson s disease, Alzheimer s disease, Huntington s disease, spongiform encephalopathies, ... -
Investigation of early endosomal sorting and budding
(2009-11-04)Early endosomes constitute a major sorting platform of eukaryotic cells. They receive endocytic carrier vesicles from the plasma membrane and trafficking vesicles from the Golgi complex and ... -
Investigation of Protein - Protein Interactions in Clathrin-Mediated Membrane Transport
(2006-11-13)Ever since it was reported that synaptic vesicle (SV) retrieval follows two kinetic phases, the molecular mechanisms corresponding to these kinetic modes have been controversially discussed. ...