Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Morgenstern, Burkhard Prof. Dr."
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Adipositas: <i>In vivo</i> Expressionsstudien über den Adipositas Faktor <i>DOR</i> und Studien zur Translationskontrolle in der frühen Adipogenese
(2012-05-22)In this thesis, mechanisms for the onset of obesity were investigated. Expression studies were performed to analyse the obesity related factor DORin an animal model and a possible effect of translational control in early ... -
Alignment-free Phylogenetic Placement and its Applications
(2023-03-03)The study of the evolutionary interrelations of living organisms has been at the heart of biological sciences all along. A revolution in sequencing techniques in the past decades has caused a massive increase in molecular ... -
Analyse und Charakterisierung regulatorischer Vorgänge in Bacillus licheniformis
(2015-05-08)Analysis of RNA-Seq data in a genome context sensitive approach to identify known and novel RNA-regulatory elements and events applied by Bacillus licheniformis DSM13 to adapt its physiology to a productive fermentation. ... -
Analyse von Translationsstarts in prokaryotischen Genomen mit Methoden des Maschinellen Lernens
(2007-12-11)Exact localization of prokaryotic translation initiation sites with automated prediction systems is still not completely solved. In this context, two approaches from the field of machine ... -
Computational methods for de novo assembly and sequencing error correction of short reads in the era of (viral) metagenomics
(2022-12-15)Viruses can affect all types of living cells, including bacteria, archaea and eukaryotes. Especially in the form of bacteriophages - bacteria infecting viruses - they have a huge impact on their host communities, driving ... -
Conformational Sampling of Enzyme dynamics: Triosephosphate Isomerase
(2012-10-17)Triosephosphate Isomerase is a glycolytic enzyme catalyzing the interconversion of Dihydroxyacetone phosphate to Glyceraldehyde-3-phosphate. TIM is a dimer and each monomer is comprised of 249 amino acids. The active ... -
Detektion funktioneller RNAs in Genomsequenzen
(2009-05-08)Using approved tools a pipeline for fRNA prediction in complete genome sequences is developed. The program allows the prediction of new and until now unknown fRNAs as well as members of ... -
Functional Phage Genomics of selected Taxa
(2019-06-26)This work reports the potential of a fully automated genome based phage prediction and classification method with ever-increasing amounts of sequencing data. Firstly, we present an approach we call ClassiPhage and ClassiPhages ... -
Komparative Genomanalyse zur Stammoptimierung produktionsnaher Bacillus-Stämme
(2011-06-30)B. licheniformis DSM13 is a Gram-positive, ubiquitous, endospore forming bacterium that is extensively used for industrial production of exoenzymes as it can secrete high amounts of protein. ... -
Molecular Dynamics Studies of the Phi29 Connector-DNA complex
(2015-04-10)During replication of the Phi29 bacteriophage, a DNA packaging motor packages the viral DNA into the procapsid against a maximum pressure difference of ~60 atm, which is generated by the already packed DNA. Several models ... -
Prokaryotic Biodiversity of Lonar Meteorite Crater Soda Lake Sediment and Community Dynamics During Microenvironmental pH Homeostasis by Metagenomics
(2016-08-24)This thesis is on the Archaea and Bacteria from a hypersaline hyperalkaline lake sediment of a meteorite impact crater named Lonar. We have surveyed the active and the total biodiversity of the sediment from Lonar. We have ... -
Robust phylogenomic inference through genome skimming as demonstrated by a systematic analysis of Nereididae
(2022-12-16)The introduction of massively parallel sequencing in the mid-2000s has truly revolutionized the field of molecular phylogenetics and ultimately our understanding of the tree of life. Despite today's existence of long-read ... -
Studying the regulation and development of circadian clock by systems biology approaches
(2020-09-24)System biology approaches, coupled with emerging omics tools, have been widely used and greatly accelerated biological and medical research and discovery. In this thesis, I will focus on applying those tools and technologies ... -
The development of an integrated database of the model organism Bacillus subtilis
(2016-01-25)In the era of “Omics” approaches, the available data is exponentially increasing and new methods must be invented to handle this data. For this purpose, databases store, maintain and provide the data, and algorithms ...