Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Neher, Erwin Prof. Dr."
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Charakterisierung von einer retrograden Modulation inhibitorischer synaptischer Transmission im Kleinhirn der Ratte
(2003-12-15)In recent years, a lot of interest has been given to retrograde modulatory mechanisms of synaptic transmission: in many regions of the central nervous system, substances released from ... -
Cytoskeletal reorganization in human blood platelets during spreading
(2017-06-21)Anucleate, human blood platelets play an important role in haemostasis to prevent excessive blood loss from a vascular damage. Their actin and microtubule (MT) cytoskeleton is especially responsible for bringing about ... -
Effect of nitric oxide and inflammatory mediators on axonal transport
(2005-11-04)Increased production of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and reactive oxygen species by glia in the central nervous system (CNS) is a hallmark of a variety ... -
Electrophysiological characterization of insulin secreting beta-cells in pancreatic tissue slices
(2004-11-09)In the present study a pancreatic tissue slice preparation was established to enable the characterization of insulin secreting β-cells in close to in vivo conditions. The procedure to obtain ... -
Epac-mediated modulation of neurotransmitter release from cultured hippocampal neurons
(2008-07-15)cAMP regulates secretory processes through both protein kinase A (PKA)-independent and PKA-dependent signaling pathways. However, their relative contributions to fast neurotransmission are ... -
Expression and function of serotonin receptor isoforms in the respiratory system
(2005-02-09)A variety of different serotonin receptors (5-HTRs) are known to modify neuronal net-work activity through G-protein activated second messenger pathways. To obtain more information about ... -
Functional properties and Ca2+-dependent feedback modulation of voltage-gated Ca2+ channels in glutamatergic nerve terminals of the mammalian auditory brainstem
(2012-03-02)The functional properties of mammalian presynaptic nerve endings remain elusive since most terminals of the central nervous system are not accessible to direct electrophysiological recordings. ... -
In vivo imaging of long-term changes in the Drosophila neuromuscular junction
(2005-02-11)So far synaptogenesis could hardly be studied in its native settings. In this thesis, an assay which allows the study of synapse formation and maturation in vivo was established in a ... -
Investigation of Protein - Protein Interactions in Clathrin-Mediated Membrane Transport
(2006-11-13)Ever since it was reported that synaptic vesicle (SV) retrieval follows two kinetic phases, the molecular mechanisms corresponding to these kinetic modes have been controversially discussed. ... -
Isolation and characterisation of synaptic vesicles from mouse brain
(2011-08-08)All eukaryotic cells exhibit a constant turnover of membrane components via trafficking of vesicles between subcellular compartments. A classical example of a dynamic membrane delimited ... -
Maturation of GABAergic signaling during brainstem development
(2007-07-13)In the central nervous system, γ-aminobutyric acid (GABA) is known to act as an inhibitory neurotransmitter, via ligand-gated GABAA receptor channels and G protein-coupled GABAB receptors. ... -
Mechanisms of posttetanic potentiation and its possible role in maturation of the calyx of Held synapse
(2006-05-12)In this work, a hitherto overlooked form of short-term plasticity was identified at the calyx of Held, a glutamatergic excitatory synapse in the auditory brainstem pathway.Brief trains ... -
Mitochondrial metabolism in hypoglossal motoneurons from mouse – implications for amyotrophic lateral sclerosis (ALS)
(2004-03-03)Motoneurons (MNs) are selectively damaged both in human amyotrophic lateral sclerosis (ALS) and corresponding mouse models of this neurodegenerative disease. A variety of studies indicate that mitochondrial dysfunction and ... -
Molecular Mechanisms of Serotonergic Signaling: Role in Neuronal Outgrowth and Receptor Oligomerization
(2010-12-21)Role of 5-HT7/G12 signaling in morpho- and synaptogenesis. The neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) modulates different aspects of early neuronal differentiation, including ... -
Molecular physiology of the inner hair cell ribbon synapses
(2005-08-05)During this work we investigated organization, molecular composition and function of hair cell ribbon synapses. We demonstrated RIBEYE, Bassoon and Piccolo to be components of IHC synaptic ... -
Molekular-Dynamik-Simulationen zum Katalysemechanismus der Acetylcholinesterase
(2002-02-14)Acetylcholinesterase plays an important role in the signal transmission in cholinergic synapses. The aim of this work is to obtain a better insight into the catalytic reaction mechanism ... -
Munc18 function in large dense-core vesicle exocytosis
(2005-03-23)Neurotransmitter and hormon release is based on Ca2+ dependent exocytosis. The sequential steps of exocytosis are executed by proteins and protein complexes. Formation of the SNARE complex ... -
Probing modes of vesicle docking in neurosecretory cells with evanescent wave microscopy
(2006-02-20)Secretory vesicles dock at the plasma membrane and proceed through several steps in preparation for Ca2+-triggered fusion. The molecular events between the first morphological contact with ... -
Role of the mGRIP1 homologue DGrip in the Drosophila neuromuscular system
(2005-07-05)Here, the identification and characterisation of the Drosophila homologue of the Glutamate Receptor Interacting Protein, DGrip is described. Mutants of DGrip show four scorable defects, a ... -
Role of the microtubulin-associated molecule tau in inflammatory-mediated axonal damage
(2008-02-14)Intracellular aggregates of the microtubule associated protein tau in neurites are the major component of neurofibrillary tangles in Alzheimer's disease and other neurodegenerative tauopathies. The exact molecular mechanism of ...