Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Outeiro, Tiago Fleming Prof. Dr."
Now showing items 1-14 of 14
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Alzheimer-like pathology in murine transgenic models: disease modification by environmental and genetic interventions
(2016-06-01)As no successful therapeutic approach to treat Alzheimer’s disease (AD) has been developed to date, preventative strategies and non-pharmacological interventions increasingly become a major research focus. In recent years, ... -
Analysis of the mechanisms of interaction of alpha-synuclein and membranes in cellular models of Parkinson´s Disease
(2018-12-04)Alpha-synuclein (aSyn) plays a crucial role in Parkinson’s disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions known as Lewy bodies. The physiological function ... -
Anti-apoptotic and neuroprotective erythropoietin/CRLF3-signalling in insects and humans
(2022-06-14)The cytokine receptor like factor 3 (CRLF3) evolved together with the eumetazoan nervous system and is present in all major groups of Animalia. Based on sequence similarities, CRLF3 was assigned to the family of class 1 ... -
C-terminal tyrosine residue modifications modulate α-synuclein toxicity in yeast as unicellular model for Parkinson´s disease
(2016-12-07)The presence of protein inclusions called Lewy bodies (LBs) that are mainly composed of misfolded and accumulated α-synuclein (αSyn) represents a hallmark of Parkinson´s disease (PD). Oligomeric αSyn species are thought ... -
From Chromatin Readers To Neuronal Networks: Finding New Treatments For Alzheimer´s Disease A Transcriptomics Approach
(2018-12-18)Alzheimer’s disease (AD) is the most common dementia-associated neurodegenerative disorder. It has detrimental social and economic impact not only on patients, but also their family and society as a whole. Current estimations ... -
Investigation on the Physiological and Pathological Aspects of the Proline-Rich Region of the Microtubule-Associated Protein Tau
(2020-12-17)The microtubule-associated protein tau is involved in several neurodegenerative diseases including Alzheimer’s disease (AD), Pick’s disease (PiD), Progressive Supranuclear Palsy (PSP) and others. The aggregation and ... -
Loss of Setd1b methyltransferase in the murine forebrain as a novel model for human intellectual disability
(2020-12-22)Methylation of histone 3 lysine 4 (H3K4me3) is an epigenetic mark for active transcription, which is mediated in mammals by six enzymes of the SET1/MLL family of histone methyltransferases (KMTs). All of them have been ... -
Modulating the aggregation of alpha-synuclein and prion protein with small molecules.
(2016-11-07)As living and health conditions improve in modern societies, the percentage of older people rises. A byproduct of this ageing is the marked increase of cases of cancer, cardiovascular, and neurodegenerative diseases. Many ... -
Molecular mechanisms underlying cortical (mal)formation: case studies of ESCO2 and EXOSC10
(2021-09-23)This work focuses on elucidating the molecular mechanisms that control the cortical development. Identification of genes and factors that direct the development of the cerebral cortex will both tell us about their ... -
Neurodegeneration induced by ß-synuclein in the context of the neurotransmitter dopamine
(2019-05-27)Objective: α-synuclein and degeneration of dopaminergic neurons have been closely associated to Parkinson´s disease. The interaction of α-synuclein with the neurotransmitter dopamine has been connected to neurodegeneration, ... -
Proteomic analysis of synaptic dysfunction in the hippocampus of late-stage Parkinson´s Disease
(2022-04-01)The present study focussed on assessing changes in the hippocampus as a result of late-stage Parkinson´s disease. Human post-mortem hippocampal samples were used to address these changes, quantifying significant alterations ... -
The role of RNA in synapse physiology and neurodegeneration in models of Parkinson’s disease
(2022-06-14)Synaptic dysfunction is an early alteration in multiple neurodegenerative disorders. Parkinson’s disease (PD) is characterised by the accumulation of α-synuclein (αsyn) in pathological inclusions known as Lewy bodies ... -
Translocator protein 18 ligand Emapunil protects against neurodegeneration in the MPTP mouse model of Parkinsonism
(2020-06-19)Parkinson’s disease (PD) is the second most common neurodegenerative disorder in old age. The presence of akinesia, rigidity and rest tremor caused by dopaminergic neuronal loss in the substantia nigra are the major clinical ... -
Vimentin protects differentiating stem cells from stress
(2020-12-10)Vimentin is the first cytoplasmic intermediate filament to be expressed in mammalian cells during early differentiation, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in ...