Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Pieler, Tomas Prof. Dr."
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A Role for Glycogen Synthase Kinase 3 beta in the Regulation of Glucagon Gene Transcription by Insulin
(2003-11-21)Insulin binding to its receptor on the a-cells in endocrine pancreas initiates a signalling cascade that results in inhibition of glucagon gene transcription. Evidence suggests that the ... -
Analysis of Tribolium head patterning by forward and reverse genetics and transgenic techniques
(2009-09-09)In this thesis several different methods have been applied to get deeper insights into the complex process of head development in insects. As model organism the red flour beetle Tribolium ... -
Die Bedeutung von BRCA1-assoziiertem Protein in der Entwicklung der lastinduzierten Myokardhypertrophie
(2009-02-17)Mitogen activated protein kinase (MAPK) pathways are regulating important cellular processes such as growth, differentiation, mitosis and apoptosis and are highly relevant for cardiac ... -
Biochemische und zellbiologische Untersuchungen zur Rolle der Cajal Bodies bei der Zusammenlagerung spleißosomaler UsnRNP Partikel
(2005-06-27)Eukaryotic pre-mRNA splicing is catalysed by a large macromolecular complex called the spliceosome. One central unit of the spliceosome is the [U4/U6.U5] tri-snRNP particle that consists ... -
Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: Role of cytokines
(2013-06-07)Background: Worldwide, colorectal cancer is the third most common malignancy. The development of the colorectal cancer (CRC) is a multistep process that involves e.g. an accumulation of mutations in tumor-growth promoting ... -
Expression screen for Wnt signaling-like phenotypes identifies Fam132b as a novel inhibitor of BMP signaling in Xenopus
(2014-03-13)The canonical Wnt signaling pathway is known to regulate multiple developmental events,including development of the digestive tract. In this study, we wanted to systematically analyze the role of the Wnt/β-Catenin signaling ... -
Function analysis of Xenopus NumbL in the context of primary neurogenesis
(2011-03-24)Members of the vertebrate Numb family of cell fate determinants have been shown to play multiple roles throughout early embryogenesis including an essential role during the development of ... -
Functional analysis of transcription factor mScrt2 in cortical neurogenesis
(2010-11-11)The neocortex, a specific for the mammals layered structure that cover the forebrain, is characterized by an enormous cellular diversity as a result of several coordinated developmental ... -
Functional characterization of m Satb1 and Satb2 in the developing neocortex
(2008-11-21)Satb1, special AT-rich sequence binding protein 1, is a transcription factor that is involved in the regulation of tissue-specific organization of chromatin. It is localized at nuclei ... -
Functions of TGF-β2 and GDNF in the Development of the Mouse Nervous System: Evidence from Double Mutant Mice
(2006-11-08)Abstract: A major area of investigations in neuroscience is directed at understanding factors that participate in neural survival versus death. A number of neurotrophic growth factors ... -
Die Funktion des Wnt Antagonisten XsFRP5 während der frühembryonalen Musterbildung des Entoderms in Xenopus laevis
(2008-05-08)In vertebrates the embryonic development of all endodermal organs follows conserved molecular mechanisms. Wnt signaling is supposed to play a key role during these processes. The gastrointestinal tract comprises the ... -
Funktion und Evolution von hochkonservierten Kopfgenen im Reismehlkäfer Tribolium castaneum
(2009-09-09)The anterior-posterior axis of all bilaterian animals is subdivided into a posterior region marked by the expression of highly conserved Hox-cluster genes and an anterior region free of ... -
Germ cell development and migration
(2005-07-29)Sexually reproducing organisms arise from gametes (sperm and egg), which develop from primordial germ cells (PGCs), a small population of cells that set aside from other cell lineages ... -
Größenegulation der Augenanlage von Xenopus laevis durch Inhibition von Hedgehog-, Fgf- und Wnt-Signalen
(2004-01-16)The molecular mechanisms, which underlie the control of organ size during embryogenesis, are only poorly understood. Using the South African clawed frog Xenopus laevis as a ... -
Identification and Functional Characterization of Novel Genes Involved in Primary Neurogenesis in Xenopus laevis
(2002-07-16)The South African claw-toed frog, Xenopus laevis, is a good model to study neurogenesis in vertebrates. Early on, at the open neural plate stage, the territory of primary neurons is nicely ... -
Identification and Functional Characterization of Trans-acting Factors Involved in Vegetal mRNA Localization in Xenopus Oocytes
(2008-07-24)Directional transport of specific mRNAs is a mechanism for the generation of asymmetry which is of primary biological importance. In Xenopus oocytes, mRNA localization to the vegetal ... -
Identifikation und funktionelle Analyse von Xdach1 und Xeya3 als morphogenetische Faktoren der Kopfentwicklung von Xenopus laevis
(2005-02-14)Dachshund (dac) and Eyes absent (eya) are two transcription factors indispensable for proper compound eye development in Drosophila melanogaster. In vertebrates homologues of dac and eya ... -
Identifikation von Zielen und molekulare Charakterisierung des RNA-Bindeproteins XSeb4R in Xenopus laevis
(2009-10-28)While developmental processes have been extensively studied in the context of transcriptional regulation, much less is known about regulation via translational regulation. RNA-binding ... -
Identifizierung neuer vegetal lokalisierter RNAs in der Xenopus laevis Oozyte und deren funktionelle Charakterisierung
(2005-12-16)Vegetally localized mRNA molecules in Xenopus laevis oocytes play important roles in the formation of the primary germ layers and the germ line. In order to identify novel vegetally localized ... -
Identifizierung und funktionelle Charakterisierung neuer RNA-Transportfaktoren in der Xenopus laevis Oozyte
(2008-06-05)RNA localization is an important strategy to create intracellular asymmetry and plays an essential role in early embryogenesis in several organisms. Revealing the molecular mechanism of ...