Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Rizzoli, Silvio Prof. Dr."
Now showing items 1-9 of 9
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Amyloid-beta driven changes in transcriptome plasticity: From OMICS to Therapy
(2016-04-06)Alzheimer’s disease is characterized by a progressive cognitive decline coinciding with the formation of amyloid plaques and tau fibrils in the human brain. It is the most common form of dementia and the number of people ... -
Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: Role of cytokines
(2013-06-07)Background: Worldwide, colorectal cancer is the third most common malignancy. The development of the colorectal cancer (CRC) is a multistep process that involves e.g. an accumulation of mutations in tumor-growth promoting ... -
Extracellular vesicle release of α-Synuclein is mediated by SUMOylation
(2015-11-13)We hypothesized that cells release and transfer α-Syn associated with EVs, followed by highly efficient internalization and induction of α-Syn aggregation in previously healthy neurons. EVs of 40-100 nm diameter can either ... -
Genetic and Pharmacological Modulation of Alpha-Synuclein Aggregation
(2017-07-18)Several neurodegenerative disorders, such as Parkinson’s disease (PD), are characterized by the deposition of misfolded and aggregated forms of a particular protein in different areas of the brain. Understanding the molecular ... -
Insights into the regulation of RNA helicases by protein cofactors
(2019-02-12)RNA helicases comprise a large family of ubiquitously expressed enzymes that remodel RNA structures and RNA-protein complexes in an NTP-dependent manner. These proteins are essential regulators of every RNA-related process, ... -
Investigation of myelin membrane adhesion and compaction in the central nervous system
(2013-02-13)Myelin is a multi-layered membrane which enwraps the axons in peripheral (PNS) and central nervous system (CNS). The formation and assembly of this structure is a multi-step process that is regulated by a variety of ... -
Monitoring mitochondrial translation with spatial resolution and high throughput strategies
(2023-05-30)Nearly all mitochondrial proteins are encoded in the nuclear genome, synthesized in the cytosol, and imported into mitochondria. However, mitochondria are semi-autonomous and possess their own genome, the mitochondrial DNA ... -
Proteomic analysis of synaptic dysfunction in the hippocampus of late-stage Parkinson´s Disease
(2022-04-01)The present study focussed on assessing changes in the hippocampus as a result of late-stage Parkinson´s disease. Human post-mortem hippocampal samples were used to address these changes, quantifying significant alterations ... -
Synaptic vesicle recycling <i>in Vivo</i>
(2012-03-12)The basic mechanism of neurotransmitter release at synapses is relatively well understood: upon arrival of an action potential, calcium influx into the nerve terminal triggers fusion of ...