Browse by type "cumulativeThesis"
Now showing items 1-20 of 107
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Impacts of warmer temperatures on the above- and belowground system of four economically important timber species
(2025-12-17)Recent decades of climate warming, along with more frequent heatwaves, have profoundly affected European forests, causing vitality loss and increased mortality in many tree species. Given the essential role forests ... -
Enhancing RNAi-Based Pest Control through Effective Target Gene Selection and Optimal dsRNA Design
(2025-12-04)The growing global population demands new strategies for sustainable pest management. Chemical insecticides, while historically successful in controlling pest populations to protect agricultural yields and suppress disease ... -
Network hyperexcitability and dopaminergic neuron loss in a novel A30P-driven Parkinson’s midbrain organoid model
(2025-11-24)Midbrain dopaminergic (mDA) neurons are essential for motor control, reward processing, emotional regulation and motivation. The degeneration of these neurons, seen in Parkinson’s disease (PD), disrupts fine motor control, ... -
Psychological Effects of Age and Hormonal Contraceptive Use in the Context of Female Reproductive Decision Making
(2025-09-05)Reproductive decision making is a central aspect of human life, shaped by both biological and psychological factors. While prior research has often focused on fertility-related outcomes, little is known about if and how ... -
Analysis of Transcription Factor Binding and Cancer Stage-Specific Regulatory Dynamics Using DNA-Binding Domain Annotations
(2025-07-31)Transcription Factors (TFs) regulate gene expression by binding to specific DNA sequences through their DNA-Binding Domain (DBD)s. Accurate modeling of TF–DNA interactions is essential for uncovering the mechanisms of ... -
Cell-type specific roles of long non-coding RNAs in Neurodegenerative diseases
(2025-07-14)Long non-coding RNAs (lncRNAs) are a heterogeneous group of RNAs that occupy a substantial proportion of the genome and are intricately involved in the regulation of various cellular processes. A notable feature of lncRNAs ... -
CNS myelin heterogeneity in species, single myelin sheaths and in Multiple Sclerosis
(2025-06-16)In the Central Nervous System (CNS), oligodendrocytes (OLGs) produce myelin which is a specialized plasma membrane that supports axons. Similarly, Schwann Cells (SCs) fulfill this role in the Peripheral Nervous System ... -
Advancing CRISPR gene therapy for Noonan syndrome: Targeting recurrent LZTR1 variants with all-in-one Cas9 and base editors in patient-derived iPSC-cardiomyocytes
(2025-05-28)Pathogenic variants in LZTR1 are causative for Noonan syndrome with early onset of a severe hypertrophic cardiomyopathy. Despite high clinical relevance, therapeutic options are highly limited, and no curative treatment ... -
Responses of bird and moth communities to forest disturbance and associated management in Central European forests
(2025-05-20)Forest disturbances – such as windthrow, bark beetle and wildfire – play a key role in shaping forest ecosystems by altering forest structure, ecosystem processes and biodiversity. Central European forests are currently ... -
Lying with Deceptive Implicatures: The Roles of Commitment, Culture, and Partisan Bias
(2025-03-25)The aim of the present work is to advance our understanding of how ordinary speakers use the term lying to categorize deceptive behaviours they inevitably encounter in their everyday lives. Although a firm grasp of how ... -
Microbial Communities in the Terrestrial Subsurface
(2025-01-23)Terrestrial subsurface habitats represent a significant portion of Earth's prokaryotic biomass. However, our understanding of microbial diversity and functions in these environments, particularly in arid regions, remains ... -
Structural basis of human mitochondrial RNA processing
(2024-12-16)Mitochondrial transcription produces polycistronic transcripts, in which ribosomal RNA (rRNA) and messenger RNA (mRNA) regions are interspersed with transfer RNA (tRNA) sequences. Endonucleolytic cleavages at the 5' and ... -
Comparative analyses of stress-induced dynamics in global differential gene expression across more than 550 million years of streptophyte evolution
(2024-11-22)The transition from aquatic to terrestrial habitats was a major evolutionary step in the evolution of plants. It ushered in the birth of embryophytes. This transition occurred before the last common ancestor (LCA) of land ... -
The role of pragmatics in early word learning
(2024-10-10)Young children show remarkable abilities in learning words from highly ambiguous surroundings. Regardless how many languages they learn, they seem to have no effort in linking a novel word to its correct meaning. ... -
Influence of clock gene homologs and Pseudomonas spp. on Verticillium dahliae development and host plant interaction
(2024-08-09)The soil-borne phytopathogenic fungus Verticillium dahliae requires a tight regulation to form different developmental structures for infection, colonization of the plant vasculature and survival in soil. The fungal life ... -
Engagement in web-based interventions for individuals who sexually abused children
(2024-05-16)Although treatment for individuals who committed sexual offenses against children (ICSOC) can reduce their likelihood of reoffending, many individuals remain without treatment due to a lack of its availability. One way to ... -
Protein Signatures of Incision Injury in Humans and Mice - a Translational Study
(2024-05-08)Acute pain is the physiological reaction of a body to noxious external stimuli such as surgical interventions. Depending on the intensity and persistence of pain, tissue recovery may be hampered leading to post-operative ... -
Computational analysis of transcriptional regulation and chromatin assembly
(2023-12-07)Primordial germ cells (PGCs), the precursors of gametes, are specified from post-implantation epiblast cells in response to bone morphogenetic protein (BMP) signaling at the onset of gastrulation in mouse. Followed by ... -
Altercentric Bias: A Potential New Window into Implicit Theory of Mind
(2023-07-24)It has been traditionally assumed that theory of mind (ToM) -our ability to ascribe mental states to others and ourselves- emerges around age four, as indicated in performance on standard explicit false belief (FB) tasks ... -
Evaluation of a Noise Reduction and Information Management System on Noise, Stress, Communication and User Acceptance of Crews in the Operating Room and the Medical Laboratory
(2023-05-16)The theoretical background includes the working definitions, theories, and models. It will be shown that noise levels exceed recommendations by the World Health Organisation and that the consequences of noise are detrimental ...