Browse by type "doctoralThesis"
Now showing items 1-20 of 1549
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The dual role of MTG3 during human mitoribosome biogenesis
(2024-12-05)Mitochondria are the main energy provider of the cell, and because of the endosymbiotic event they arise from, still contain a small independent genome. Only with the vast ATP production through the mitochondrial OXPHOS ... -
Computational Analysis of Prognostic Factors, Immune Microenvironment, and T-Cell Receptor Repertoires in Lymphoma
(2024-11-22)The immune system plays an important role in the development and progression of cancer. While solid cancers like carcinomas primarily affect specific organs and tissues, hematologic malignancies are not always so localized, ... -
Investigation of TOMM20 Interactome in Relation to Protein Quality Control and Translocation
(2024-11-11)The human mitochondria are home to a vast repertoire of approximately 1,500 proteins, most of which are synthesized within the cytosol and post-translationally translocated into the mitochondria. Amidst the intricate ... -
Caregiver-child dynamics in early language development: The influence of children’s interests and parental input on children’s word learning
(2024-10-30)Active child views of children’s development postulate that children are active participants in their own learning and development, choosing what information and from whom to learn. More recently, research has demonstrated ... -
Multi-omics studies of RNA polymerase II transcription regulation by cyclin-dependent kinases
(2024-10-30)Phosphorylation of the C-terminal repeat domain (CTD) of RNA polymerase II (Pol II) plays a central role in the regulation of gene transcription in eukaryotes. In yeast and mammals, the CTD is highly conserved and consists ... -
Coordinated Transcriptional Response to Stress-Related Disorders in Multiple Brain Regions: A Spatial and snRNA-sequencing Study in Mice
(2024-10-22)Recent work has demonstrated specific, genome-wide transcriptional changes related to fear and anxiety in rodent animal models and post-mortem human brain samples on the level of individual brain regions and even cell ... -
Specification of Multiple Processes in Metacontrast Masking
(2024-09-13)Metacontrast masking has been widely used as a tool to study visual perception, but there is still no comprehensive theory of the phenomenon. There is no lack of theories, but a synthesis of the different approaches seems ... -
High-resolution analysis of regulatory interactions and nano-scale chromatin structures
(2024-09-11)Despite having the same genetic blueprint, the development of a complex, multicellular organism from a single fertilized egg results in a wide variety of hundreds distinct cell types, each uniquely contributing to the ... -
Soil food webs change with land use: basal resources, functional diversity and trophic niche breadth
(2024-09-06)The diversity and interactions of organisms, along with ecosystem functions and stability, are intricately linked to food webs. Among these, soil food webs have only been investigated relatively recently due to the small ... -
Community dynamics and trophic niches of soil fauna in Central European forests
(2024-09-06)Global change is altering the state of forest ecosystems, threatening their integrity. A number of studies have reported declines in aboveground arthropod diversity over the last decade and indicated management practices ... -
Sensory Attenuation related to Action-effect Prediction and the Sense of Agency
(2024-09-03)Sensory consequences caused by a self-generated action (action-effect) are assumed to lead to less intense perception compared to external stimuli. This reduced perception referred to as sensory attenuation is suggested ... -
Structural and functional characterization of TIM22 complex in the inner mitochondrial membarne
(2024-08-16)Mitochondria have gained significant attention in disease models due to their crucial role in cellular energy production and metabolic activity. Understanding how mitochondria maintain their function and interact with other ... -
An automated data integration platform for interpreting genomic data and reporting treatment options in molecular tumor boards
(2024-08-16)This thesis presents significant advancements in precision oncology, focusing on enhancing MTB workflows through the development and integration of innovative bioinformatics tools and methodologies. These contributions ... -
Cognitive Foundations of Ascribing Intentional Action
(2024-08-09)Understanding and interpreting actions is fundamental for profoundly social beings like humans. We explain and predict intentional actions of others by reference to mental states, such as beliefs, desires and intentions. ... -
Characterization of the Phosphomimetic Mutant Y39E of a-Synuclein
(2024-08-06)α-Synuclein (aSyn) has long been identified as a key factor in the pathogenesis of Parkinson's Disease (PD), with familial mutations in the SNCA gene contributing to the aberrant aggregation of aSyn. Its aggregation results ... -
Mobile Cognitive Interventions in Mental Disorders
(2024-08-05)Mental disorders pose a significant public health challenge, contributing substantially to disability-adjusted life years and increasing mortality rates. Despite their prevalence, the mechanisms underlying the development, ... -
Trophic ecology of earthworms: the relative role of litter- and root-derived resources investigated with compound-specific stable isotope analysis of amino acids
(2024-07-23)Earthworms, known as ecosystem engineers, shape the structure and functioning of ecosystems by altering nutrient cycling, habitat architecture and plant growth due to feeding interactions or physiological activities. They ... -
The Role of Low-Level Visual Features in the Emotional and Motivational Relevance of Symbolic Stimuli
(2024-07-16)In our daily lives, we encounter a wide range of visual stimuli, but printed words are critical for communication and information acquisition. Emotional words receive preferential attention, resulting in modulations of ... -
The role of Wnt signalling in the microtubule-mediated maintenance of chromosomal stability
(2024-07-05)Chromosomal instability (CIN) is a major hallmark of cancer and represents a driving force for tumourigenesis, tumour progression, and the development of therapy resistance. CIN can be subdivided into structural CIN ... -
Analysis of the Antiviral Restriction Factor Shiftless in the context of HIV-1 Programmed –1 Ribosomal Frameshifting
(2024-07-05)The human immunodeficiency virus 1 (HIV 1) is responsible for a major global health crisis, the acquired immunodeficiency syndrome (AIDS) pandemic. Retroviruses integrate their genetic material into the genome of host ...