Fakultät für Biologie und Psychologie (inkl. GAUSS)
Recent Submissions
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Investigation of cytoplasmic long noncoding RNA in Saccharomyces cerevisiae
(2025-06-12)Research on lncRNAs has increased in the past, but little is known about their function. Recently, discoveries have given us insight into sense- and asRNA regulation in yeast. dsRNA is formed in the nucleus and shuttles ... -
Advancing CRISPR gene therapy for Noonan syndrome: Targeting recurrent LZTR1 variants with all-in-one Cas9 and base editors in patient-derived iPSC-cardiomyocytes
(2025-05-28)Pathogenic variants in LZTR1 are causative for Noonan syndrome with early onset of a severe hypertrophic cardiomyopathy. Despite high clinical relevance, therapeutic options are highly limited, and no curative treatment ... -
Transformation of waste gases into biocommodities by syngas fermentation
(2025-05-28)This study describes a total of 13 novel gas-fermenting strains from four different bacterial genera. Three strains represent a new species. These acetogenic and carboxydotrophic hydrogenogenic strains were successfully ... -
Tau oligomers and stress granules: Molecular insights into slowly and rapidly progressive Alzheimer’s disease
(2025-05-27)Alzheimer’s disease (AD) exhibits substantial clinical and molecular heterogeneity, with rapidly progressive AD representing a distinct and aggressive subtype. This study provides an in-depth characterization of stress ... -
Dendroclimatic investigation of European beech growth dynamics along a precipitation gradient in northern Germany
(2025-05-22)This thorough study of European beech (Fagus sylvatica) growth limits in Northern Germany shows the major difficulties caused by climate change and global warming. Drawing on the findings of three main chapters, we arrive ... -
The temporal characteristics of the motion bridging effect and a connected illusion: Time-related interactions and dependencies in a two-process-model
(2025-05-22)The Motion Bridging Effect (MBE) is a visual illusion in which a motion that is not consciously visible, due to high speed, induces an illusory rotation percept in a stationary stimulus (test ring) that is presented ... -
Effects of environmental change on grassland birds in the Central-Asian flyway through the annual cycle
(2025-05-20)Land use change is a significant driver of biodiversity loss, but its impacts have been largely studied with a particular focus on temperate regions and forest ecosystems. In this thesis, I used bird abundance, occurrence, ... -
Responses of bird and moth communities to forest disturbance and associated management in Central European forests
(2025-05-20)Forest disturbances – such as windthrow, bark beetle and wildfire – play a key role in shaping forest ecosystems by altering forest structure, ecosystem processes and biodiversity. Central European forests are currently ... -
Land Use Change in Papua, Indonesia – Assessing Deforestation Patterns and Predicting Future Hotspots of Habitat Loss to Inform Spatial Conservation Planning
(2025-05-08)New Guinea, the world’s largest tropical island, harbors some of the most biologically diverse and unique ecosystems. Despite its global ecological significance and endemic biodiversity, the region remains one of the most ... -
Communication of Colletotrichum graminicola in development and pathogenic maize interactions
(2025-05-05)Colletotrichum graminicola is a filamentous ascomycete that infects Zea mays and reduces the annual yield by 10-20 % worldwide. The fungus produces two asexual spore types, oval and falcate-shaped conidia of which the ... -
Evolution of polyploidy and apomixis in the pantropically distributed and species-rich genus Zanthoxylum (Rutaceae)
(2025-04-22)The proto-Rutaceae group includes genera with significant economic and evolutionary importance, yet their phylogenetic relationships and evolutionary mechanisms remain incompletely understood. This thesis focuses on the ... -
Lying with Deceptive Implicatures: The Roles of Commitment, Culture, and Partisan Bias
(2025-03-25)The aim of the present work is to advance our understanding of how ordinary speakers use the term lying to categorize deceptive behaviours they inevitably encounter in their everyday lives. Although a firm grasp of how ... -
Social evaluation and decision-making in nonhuman primates
(2025-03-25)One of the challenges of living in a group is constantly having to decide when, how, and whom to interact with among several conspecifics in plenty of different contexts. For optimal decision-making, social animals can ... -
The role of chromatin hubs in the regulation of gene expression and maintenance of genomic integrity
(2025-03-20)The correct development and functioning of complex organisms rely on precise spatiotemporal regulation of gene expression and on efficient maintenance of their genomic stability. Regulation of gene expression during ... -
The Melody of Miscommunication in the Heart Decoding LZTR1 deficiency with a Multicellular Focus
(2025-03-20)LZTR1 deficiency is a known cause of Noonan syndrome (NS) and is linked to early-onset and severe hypertrophic cardiomyopathy (HCM). Despite the recognized importance of paracrine communication in cardiac pathology, the ... -
Fast inference in flexible high dimensional models of gene co-expression and genotype-gene expression interaction
(2025-03-20)As more high-throughput sequencing data is produced from ever-growing human cohorts, understanding human biology becomes a more and more quantitative and statistical task. Starting notably with the data made available in ... -
Decision-making under risk in Barbary macaques (Macaca sylvanus)
(2025-02-24)Risk is ubiquitous in the everyday lives of all animals. Individuals often face precarious situations, such as unpredictable resources and exposure to predators, in which their decisions may lead to a variety of possible ... -
The roles of long non-coding RNAs in CNS diseases with a focus on astroglial-neuronal communication
(2025-02-14)Aging is accompanied by a decline of cognitive functions and represents a major risk factor for the development of neurodegenerative diseases such as Alzheimer’s disease (AD). Key pathological changes linked to AD are the ... -
A nidulans development and secondary metabolism requires coordinated VeA nuclear import and export
(2025-02-14)Survival of multicellular organisms requires the functional interplay between complex regulatory networks including gene expression, the ubiquitin proteasome protein degradation system, and intracellular transport control. ... -
Alpha-synuclein amyloid aggregation: From basic to translational research
(2025-02-05)Neurodegenerative diseases are a heterogeneous group of disorders affecting the lives of millions of people worldwide. A shared pathologic hallmark is the appearance of insoluble aggregates in the brain. The components of ...