Fakultät für Biologie und Psychologie (inkl. GAUSS)
Recent Submissions
-
The roles of long non-coding RNAs in CNS diseases with a focus on astroglial-neuronal communication
(2025-02-14)Aging is accompanied by a decline of cognitive functions and represents a major risk factor for the development of neurodegenerative diseases such as Alzheimer’s disease (AD). Key pathological changes linked to AD are the ... -
A nidulans development and secondary metabolism requires coordinated VeA nuclear import and export
(2025-02-14)Survival of multicellular organisms requires the functional interplay between complex regulatory networks including gene expression, the ubiquitin proteasome protein degradation system, and intracellular transport control. ... -
Alpha-synuclein amyloid aggregation: From basic to translational research
(2025-02-05)Neurodegenerative diseases are a heterogeneous group of disorders affecting the lives of millions of people worldwide. A shared pathologic hallmark is the appearance of insoluble aggregates in the brain. The components of ... -
Single-cell studies of mammalian ovaries
(2025-01-31)Ovarian aging progresses more rapidly than in other organs. Female fertility declines exponentially after the age of 35, and as women increasingly delay childbearing, it is paramount to understand the underlying etiology ... -
Proteogenomic peptide discovery in large search spaces
(2025-01-30)Novel peptide and protein discovery is of therapeutical relevance and ignited the development of methods for their identification, commonly done via mass spectrometry. The latter relies on a well-characterised proteogenomic ... -
Microbial Communities in the Terrestrial Subsurface
(2025-01-23)Terrestrial subsurface habitats represent a significant portion of Earth's prokaryotic biomass. However, our understanding of microbial diversity and functions in these environments, particularly in arid regions, remains ... -
Children’s Language Learning and Processing in Digital Social Interactions
(2025-01-10)Language is inherently a social tool, and nearly all questions concerning its origins, development, and processing raise a discussion of social interactions. As technological advancements transform how we communicate – ... -
The long-term effects of fire, climate, and human impact in the highland and lowland ecosystems of Sumatra Indonesia
(2025-01-09)Sumatra, Indonesia is one of the outstanding biodiversity hotspots of the world. Over the past few decades, the primary forests of this island, from the highlands to the lowlands, have experienced a remarkable transformation ... -
Time-sensitive reconstruction of joint evolutionary trees in a host-parasite model with host switches
(2024-12-20)This thesis focuses on mathematical models that describe the joint evolution of host-parasite systems in the presence of host switches, or in other words, horizontal transfers. This is a phenomenon where a parasite individual ... -
Social evaluation and partner choice in the tolerant multi-level society of Guinea baboons
(2024-12-18)Group living animals must navigate complex social environments, continuously updating their knowledge of group members to help them make appropriate social decisions in both competitive and cooperative interactions with ... -
Structural basis of human mitochondrial RNA processing
(2024-12-16)Mitochondrial transcription produces polycistronic transcripts, in which ribosomal RNA (rRNA) and messenger RNA (mRNA) regions are interspersed with transfer RNA (tRNA) sequences. Endonucleolytic cleavages at the 5' and ... -
The dual role of MTG3 during human mitoribosome biogenesis
(2024-12-05)Mitochondria are the main energy provider of the cell, and because of the endosymbiotic event they arise from, still contain a small independent genome. Only with the vast ATP production through the mitochondrial OXPHOS ... -
Computational Analysis of Prognostic Factors, Immune Microenvironment, and T-Cell Receptor Repertoires in Lymphoma
(2024-11-22)The immune system plays an important role in the development and progression of cancer. While solid cancers like carcinomas primarily affect specific organs and tissues, hematologic malignancies are not always so localized, ... -
Comparative analyses of stress-induced dynamics in global differential gene expression across more than 550 million years of streptophyte evolution
(2024-11-22)The transition from aquatic to terrestrial habitats was a major evolutionary step in the evolution of plants. It ushered in the birth of embryophytes. This transition occurred before the last common ancestor (LCA) of land ... -
Investigation of TOMM20 Interactome in Relation to Protein Quality Control and Translocation
(2024-11-11)The human mitochondria are home to a vast repertoire of approximately 1,500 proteins, most of which are synthesized within the cytosol and post-translationally translocated into the mitochondria. Amidst the intricate ... -
Multi-omics studies of RNA polymerase II transcription regulation by cyclin-dependent kinases
(2024-10-30)Phosphorylation of the C-terminal repeat domain (CTD) of RNA polymerase II (Pol II) plays a central role in the regulation of gene transcription in eukaryotes. In yeast and mammals, the CTD is highly conserved and consists ... -
Caregiver-child dynamics in early language development: The influence of children’s interests and parental input on children’s word learning
(2024-10-30)Active child views of children’s development postulate that children are active participants in their own learning and development, choosing what information and from whom to learn. More recently, research has demonstrated ... -
Coordinated Transcriptional Response to Stress-Related Disorders in Multiple Brain Regions: A Spatial and snRNA-sequencing Study in Mice
(2024-10-22)Recent work has demonstrated specific, genome-wide transcriptional changes related to fear and anxiety in rodent animal models and post-mortem human brain samples on the level of individual brain regions and even cell ... -
The role of pragmatics in early word learning
(2024-10-10)Young children show remarkable abilities in learning words from highly ambiguous surroundings. Regardless how many languages they learn, they seem to have no effort in linking a novel word to its correct meaning. ... -
Specification of Multiple Processes in Metacontrast Masking
(2024-09-13)Metacontrast masking has been widely used as a tool to study visual perception, but there is still no comprehensive theory of the phenomenon. There is no lack of theories, but a synthesis of the different approaches seems ...