Recent Submissions
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Multi-layered proteogenomic characterization of mouse brain aging in physiology and disease
(2026-01-06)Functional decline and increased susceptibility to neurodegenerative disease are the result of a complex interplay of molecular changes that accompany brain aging. These changes include accumulation of cellular damage, ... -
Responses of timber species to climatic changes in Northern Germany: Studies on the radial stem growth and the fine root system of European beech, Sessile oak, Scots pine and Douglas fir along a gradient of increasing aridity
(2025-12-17)Climate change with rapid warming and increasing atmospheric and edaphic drought exposes trees and forests to growing stress. Most of Central Europe’s economically important tree species have suffered vitality losses, ... -
Impacts of warmer temperatures on the above- and belowground system of four economically important timber species
(2025-12-17)Recent decades of climate warming, along with more frequent heatwaves, have profoundly affected European forests, causing vitality loss and increased mortality in many tree species. Given the essential role forests ... -
Regulation of the telomerase
(2025-12-16)Transcription is essential to transfer genetic information and to allow cell viability. Cells must control the resulting traffic of RNA polymerases (RNAP) by holding transcription into gene boundaries and prevent conflicts ... -
A journey toward independence in young mandrills ("Mandrillus sphinx"): the intertwined effects of early life adversity and maternal investment
(2025-12-15)Early life adversity (‘ELA’) can have lasting effects on development influencing both survival and physical growth in wild animal populations, with maternal care playing a crucial role in shaping these trajectories and ... -
Functional Reconstitution of SLC18 Family Transporters
(2025-12-12)The Solute Carrier (SLC) family proteins are a diverse group of proteins performing many vital functions from bacteria to humans. Vesicular neurotransmitter transporters (VNTs) also belong to the SLC family. Based on ... -
Establishing proximity-dependent protein labeling to investigate co-chaperone mediated effector secretion in Ustilago maydis
(2025-12-10)The complex process of protein folding within the endoplasmic reticulum (ER) of the corn smut fungi Ustilago maydis depends on the coordinated action of chaperone and their associated co-chaperone proteins. The unfolded ... -
Synthesis and characterization of fluorescent probes targeting Histone Deacetylase 6 for live cell imaging
(2025-12-10)Histone Deacetylase 6 (HDAC6) is a unique enzyme that plays a central role in major cellular processes, including cytoskeletal regulation, protein quality control, and stress responses. Its dysregulation is linked to many ... -
Resolving intermediate states of mitotic entry
(2025-12-08)Mitosis, the division of cells, is a fundamental biological process essential for growth, tissue repair, and the propagation of genetic material. Mitosis is tightly regulated and its dysregulation has severe consequences, ... -
Investigating biocompatibility of super-resolution compatible fluorescent DNA probes in mouse living tissues
(2025-12-08)Fluorescence nanoscopy allows the observation of living biological structures at the nanometer scale. However, choosing the best fluorophore for in-vivo imaging often is a challenging task as systematic studies investigating ... -
Enhancing RNAi-Based Pest Control through Effective Target Gene Selection and Optimal dsRNA Design
(2025-12-04)The growing global population demands new strategies for sustainable pest management. Chemical insecticides, while historically successful in controlling pest populations to protect agricultural yields and suppress disease ... -
Generation and characterization of an otic bioengineered neuronal organoid (oBENO) from human pluripotent stem cells
(2025-12-03)Hearing loss impacts nearly 20% of the global population, and according to estimations its prevalence will increase by 2050, affecting around 1 in 4 individuals. The most common form of hearing impairment, sensorineural ... -
Community assembly processes of intertidal salt marsh microarthropods
(2025-12-01)Salt marshes are highly dynamic ecosystems at the land–sea interface, shaped by steep environmental gradients and frequent disturbances. They provide critical ecosystem services, including coastal protection, nutrient ... -
Untersuchungen zum Wasserhaushalt tropischer Bäume in Abhängigkeit von der Meereshöhe in Süd-Ecuador
(2025-11-27)The scope of this research study examines the influence elevation has on the water status in tropical montane rainforests in southern Ecuador. The investigation focused upon the vessel anatomy of branches and roots as well ... -
Ecological and functional significance of plant hydraulics in a changing climate
(2025-11-27)This habilitation treatise evolved from seven years of postdoctoral work in the Department of Plant Ecology and Ecosystem research at the University of Göttingen. During this time, I had the opportunity to continue my ... -
Network hyperexcitability and dopaminergic neuron loss in a novel A30P-driven Parkinson’s midbrain organoid model
(2025-11-24)Midbrain dopaminergic (mDA) neurons are essential for motor control, reward processing, emotional regulation and motivation. The degeneration of these neurons, seen in Parkinson’s disease (PD), disrupts fine motor control, ... -
Uncovering the interactome of peripheral myelin protein 22 kDa (PMP22) to understand its role in health and neuropathy
(2025-11-20)PMP22, a hydrophobic glycoprotein, is crucial for proper myelination in Schwann cells of the peripheral nervous system. Dosage alterations lead to the neuropathies Charcot-Marie-Tooth disease 1A (CMT1A), where PMP22 is ... -
Functional relevance of oligodendroglial CDC42 effector proteins CDC42EP1 and CDC42EP2 in myelin morphogenesis
(2025-11-12)Myelin sheaths are composed of multiple compacted membrane layers that tightly encase the underlying axon. Structural abnormalities of myelin indicate pathological processes and are frequently associated with neurological ... -
Computational analysis of nucleosome assembly and cis-regulatory DNA elements
(2025-11-12)Induced pluripotent stem cells (iPSCs) represent embryonic stem cells (ESCs) that are reprogrammed from somatic stem cells. iPSCs can be directed to differentiate into any cell type in the human body, therefore, holding ... -
Comparative Cognitive Flexibility Assessment: Multidimensional set-shifting in monkeys, adult humans and children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD)
(2025-11-10)This thesis aims to provide a be0er and more comprehensive understanding of one of the crucial execu8ve func8ons: cogni8ve flexibility (Chapters 2 and 3). To that end, we have developed a novel mul8-dimensional set-shiEing ...