Browsing Fakultät für Agrarwissenschaften (inkl. GAUSS) by Advisor & Referee "Simianer, Henner Prof. Dr."
Now showing items 1-20 of 39
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Development of an optimization framework for complex breeding programs based on the Modular Breeding Program Simulator (MoBPS)
(2025-05-16)The aim of this thesis is to develop an optimization framework for complex breeding programs that involve numerous input parameters, auxiliary constraints, and stochastic outputs. Chapter 1 introduces the topic of stochastic ... -
Understanding the Effective Number of Independent Chromosome Segments as a Tuning Parameter for Genomic Prediction
(2025-04-16)The effective number of independently segregating chromosome segments (𝑀𝑒) is a key parameter in animal selection. Its relevance lies within the methods to obtain the accuracy of genomic prediction. However, there is ... -
Modeling and Optimization of Animal Breeding Programs
(2024-11-22)Simulation software can be used to model and optimize breeding programs. In the current work, the “Modular Breeding Program Simulator” (MoBPS) was applied to demonstrate this on three examples from layer, horse and pig ... -
Dissecting intraspecific variation in body size related traits in Drosophila melanogaster
(2024-10-23)Understanding the evolution of complex morphological traits is one of the main challenges in biology. This requires the identification of the causative genomic regions and the molecular changes responsible for phenotypic ... -
Investigation of machine learning approaches to predict quantitative traits using environmental and genomic information
(2023-02-01)In plant breeding, genotype-by-environment (G × E) interactions represent a substantial source of variation underlying complex phenotypic traits. A better understanding of G × E interactions can be beneficial to design ... -
Arrays and beyond: Evaluation of marker technologies for chicken genomics
(2022-01-04)A key research question in livestock research is how livestock’s phenotypic diversity is shaped by its genomic diversity. Genomic diversity is thereby assessed through genomic markers. The use and definition of genomic ... -
Deciphering the genetic background of quantitative traits using machine learning and bioinformatics frameworks
(2021-10-08)In this thesis, I developed two frameworks that can help highlight the genetic mechanisms underlying quantitative traits. In this regard, my focus was to design efficient methodologies to discover genotype-phenotype ... -
Accounting for Epistasis in Genomic Phenotype Prediction
(2021-06-03)Wide availability of genomic data has had a considerable impact on plant and animal breeding programs which enables the study of genotypes and their relationships with phenotypes. Improving genomic prediction accuracy is ... -
Identification of candidate signature genes and key regulators associated with trypanotolerance in the Sheko breed
(2020-05-19)African Animal Trypanosomiasis (AAT) is caused by a protozoan parasite that affects the health of livestock. Livestock production in Ethiopia is severely hampered by AAT and various controlling measures were not successful ... -
Retrieving patterns of genetic diversity in a global set of chicken breeds
(2020-02-06)The chicken was first domesticated about 6000 B.C in Asia. Today the species is widely spread across the globe providing a good source of quality protein. There have been concerns about the loss of genetic diversity within ... -
Genotype by temperature interaction effects on sex determination in zebrafish (Danio rerio)
(2019-12-06)The mechanism of sex determination and gonad differentiation in zebrafish is one of the more challenging research questions and complex puzzles in biology. The regulation of sexual dimorphism in this species is not yet ... -
Methods and software to enhance statistical analysis in large scale problems in breeding and quantitative genetics
(2019-11-08)The aim of this thesis is the development of methods and software to enhance the statistical analysis in large scale problems in breeding and quantitative genetics. In Chapter 1 a brief introduction to the subject of big ... -
Integrating Omics Data into Genomic Prediction
(2019-07-26)Prediction of genetic values plays a central role in quantitative genetics and breeding. Genomic prediction making use of genome-wide single nucleotide polymorphisms (SNPs) was widely adopted to predict breeding values in ... -
Genomic and conventional evaluations for fertility traits in pigs
(2019-01-17)The aim of genomic selection (GS) is to predict breeding values with high accuracy for young animals (without own phenotypic record) as early as possible. GS can increase the accuracy of the breeding values at the time ... -
Incorporating Interactions and Gene Annotation Data in Genomic Prediction
(2018-10-08)In this work, we consider theoretical and practical aspects of models incorporating interactions, so called "epistasis models''. Moreover, we follow approaches towards the incorporation of biological prior knowledge into ... -
Sequence-Based Analyses of the Goettingen Minipig Genome
(2018-07-27)Among the known pig breeds, the Göttingen Miniature Pig (GMP) stands out due to its special characteristics and history. Its current appearance dates back to the 1960´s when animal scientists from Goettingen took the effort ... -
Genetic evaluation of longevity in dairy cattle - A new model for an old trait
(2017-11-23)Longevity is an important trait in dairy cows, reflecting the overall functionality of a cow. The aim of this thesis was the development of a new model for the routine genetic evaluation of longevity in German Holsteins. ... -
Studies on Chicken Hatchability and Its Relation with Egg Yolk Metabolites
(2017-03-27)Hatchability is an important trait for the chicken industry because of its high impact on chicken output. The embryonic survival ability in fertile eggs is greatly influenced by the offspring genotype and the quality of ... -
Lost in Transition - Genetic, Transcriptomic and Breeding Aspects of Metabolic Robustness in Dairy Cows
(2016-12-12)The transition phase of dairy cows is marked by severe metabolic stress resulting from a discrepancy of a high energy demand for rapidly increasing milk production and limited feed intake. Here, a failure in metabolic ... -
Genomic selection in farm animals: accuracy of prediction and applications with imputed whole-genome sequencing data in chicken
(2016-03-15)Genomic prediction has been successfully applied in many livestock breeding schemes, based on different densities of single nucleotide polymorphism (SNP) array data. With the availability of whole-genome sequencing (WGS) ...