Browsing GZMB - Göttinger Zentrum für molekulare Biowissenschaften by Issue Date
Now showing items 21-38 of 38
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Untersuchungen zur Funktion der Gene MPH1 und MMS2 aus Saccharomyces cerevisiae bei der fehlerfreien Umgehung von replikationsarretierenden DNA-Schäden
(2010-02-25)in vivo error free bypass of replication blocking lesions is done by at least two distinct processes: homologous recombination via sister chromatid interaction (SCI) and post replicative repair (PRR). Additionally PRR is ... -
Untersuchungen zur Wirksamkeit von Dacarbazin und Temozolomid bei der Behandlung des kutanen Melanoms in Assoziation mit DNA-Reparatur
(2010-02-09)The aim of this study was to identify individual host markers for hematologic side effects and treatment efficacy of dacarbazine or temozolomide in melanoma treatment. Such markers could facilitate the decision for or ... -
Participation of Eag1 in tumor relevant pathways
(2010-01-12)Ether--go-go-1 (Eag1) is a CNS-localized voltage-gated potassium channel that is found ectopically expressed in a majority of extra-cranial solid tu- mors. While evidence linking Eag1 to tumor biology has been well ... -
Expression of SLC transporters in Chronic Lymphocytic Leukaemia cells and their interaction with cytostatics
(2009-11-18)Chronic Lymphocytic Leukaemia, CLL, is one of the most common forms of leukaemia in the elderly. The treatment regimen determines the outcome of patients with CLL and the efficiency of this treatment is modulated by the ... -
Gene prediction in metagenomic sequencing reads
(2009-11-13)Gene prediction is an essential step in the annotation of metagenomic sequencing reads. Since most metagenomic reads cannot be assembled into long contigs, specialized gene prediction tools are required for the analysis ... -
The role of Lissencephaly-1 protein in male germ cell differentiation
(2009-07-24)In the present study the function of Lissencephaly-1 protein in male germ cell differentiation was analysed. A gene trap mouse model (L39) in which a gene trap vector had integrated in intron 2 of Lis1 gene resulted in ... -
Investigation of Protein Structure and Dynamics
(2009-07-22)This thesis addresses three aspects of protein function:Part I describes the structural investigation of a calmodulin-peptide complex by NMR spectroscopy. The intracellular calcium sensor ... -
Functions of Vti1a and Vti1b in the Development of the Mouse Nervous System: Evidence from Double Knockout Mice
(2009-02-12)In eukaryotic cells molecules need to be transported to their correct intracellular destination without compromising the structural integrity of cellular compartments in order to maintain homoeostasis and to allow appropriate ... -
Growth, fruiting body development and laccase production of selected coprini
(2008-11-26)The coprini are a form group of mushrooms that grow mainly on compost and horse dung and that for over 100 years were thought to present one genus. Only in 2001 it was discovered by Redhead and coworkers by molecular ... -
Mikroautophagischer Abbau von Teilen der Kernhülle und Untersuchungen zum Transport und der Aktivität von Atg15p in der Hefe Saccharomyces <i>cerevisiae</i>
(2008-08-12)Autophagy is a ubiquitous process, occurring in all eukaryotic cells. Microautophagy sequesters cytoplasm or organelles by invagination or septation of the vacuolar membrane. In Saccharomyces ... -
Patched-assoziierte Tumoren: Modifikatorgene und Pathogenese
(2008-06-05)Patched (Ptch), a component of the Hedgehog (Hh)/Ptch signalling cascade, is frequently mutated in basal cell carcinoma (BCC), medulloblastoma (MB) and rhabdomyosarcoma (RMS). Ptchneo67/+ mice, in which exons 6 and 7 are ... -
Functional Characterisation of Syndecan, a heparan sulpahte proteoglycan, in Slit/Robo signalling
(2008-04-25)Syndecan (Sdc) is a type I transmembrane protein characterized by the presence of linear sugar chains called heparan sulphate glycosaminoglycans (HSGAGs) linked to its extracellular domain. Sdc was shown to be critical for ... -
Identifizierung und Charakterisierung extrazellulärer Proteine unter dem Einfluss von Verticillium longisporum in Arabidopsis thaliana und Raps (<i>Brassica napus</i>)
(2008-03-04)Verticillium species are soil-borne, xylem-colonizing fungi with worldwide distribution in temperate and subtropical regions. They cause vascular disease in many agriculturally important crops. Verticillium longisporum ... -
Genomics and Phylogeny of Motor Proteins: Tools and Analyses
(2008-02-19)This work is a collection of several projects that are mainly concerned with the genomics and the phylogeny of Myosins. Two database driven web applications are described. The first, CyMoBase (www.cymobase.org) ... -
Die Funktion der inflammatorischen CCR2+ Monozyten bei der postnatalen Mikrogliaentwicklung und bakteriellen Meningitis
(2008-02-12)The central nervous system (CNS) differs from other organs in its privileged status in relation to the immune system. To ensure a specific and stable neuronal environment, the blood-brain barrier separates it from the ... -
Ein neu entdeckter Weg der Reparatur hydrolytisch geschädigter DNA-Cytosinreste, etabliert im thermophilen Archaeon Methanothermobacter thermautotrophicus ΔH
(2007-11-21)The DNA bases cytosine, adenine and guanine can be deaminated at the exocyclic aminogroups by spontaneous hydrolysis. Cytosine deamination leads to the RNA base uracil and is of particular mutagenic relevance, because ... -
Proteome-wide Identification of New Molecular Targets Affected by Methotrexate in Acute Promyelocytic Leukaemia Cell Line
(2007-06-11)Methotrexate (MTX) was first introduced as a cytotoxic agent that inhibits nucleotide biosynthesis in various cancer disorders. Accumulating evidences suggest that MTX inhibits the proliferation of malignant cells by ... -
Transcriptional control in the context of primary neurogenesis
(2006-09-18)The Myc/Max/Mad network of bHLH-Zip transcription factors plays an essential role in a variety of cellular processes including proliferation, differentiation and apoptosis. Mxi1, a Mad family member, was previously ...