Dokumente GZMB - Göttinger Zentrum für molekulare Biowissenschaften nach Titel
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A functional analysis of a signaling center of the insect head
(2014-08-06)Most of our knowledge on embryonic development comes from the fruit y Drosophila melanogaster. An elaborate genetic model explains the segmentation process in the trunk. However, the anterior head region is patterned ... -
Analyse der Funktion des Miz1 Gens bei Kardiomyopathie
(2012-03-27)The sarcomeric Z-disc is the main structure of the decentralized model of the muscle mechanotransduction. Proteins, which are anchored to the Z-disc are associated with cardiomyopathy. An example is the muscle LIM protein, ... -
Assembly pathway of the fungal COP9 signalosome
(2022-12-20)The conserved eight-subunit COP9 signalosome (CSN complex) controls the exchange of E3 ubiquitin cullin RING ligase receptors, and therefore the specificity of protein degradation in eukaryotic cells and it is required ... -
Characterization of Lipoxygenases from Cyanothece sp.
(2016-12-12)Lipoxygenases (LOXs) are non-heme iron- or manganese-containing dioxygenases that catalyze the regio- and stereospecific peroxidation of polyunsaturated fatty acids containing at least one cis,cis-1,4-pentadiene system. ... -
Characterization of Mitochondrial Calcium Uniporter in Barth Syndrome Models
(2020-07-15)The Barth Syndrome (BTHS) is caused by the loss of the mitochondrial acyltransferase tafazzin, which is involved in the remodeling process of the hallmark mitochondrial glycerophospholipid cardiolipin. Cardiolipin maintains ... -
Charakterisierung klinisch-relevanter Bakterien mittels Proteotypisierung
(2019-05-03)In case of a disease outbreak fast and reliable detection of the source of infection is crucial. For this reason, typing of microbial species, also at the below-species level is an important task of clinical microbiological ... -
Chromatin affinity purification coupled with mass spectrometry indetifies novel histone ubiquitylation interactors
(2018-07-12)Histone ubiquitylation is the post-translational covalent attachment of ubiquitin to histones. Ubiquitylation of histones regulates chromatin-templated processes through a combination of structural and functional effects. ... -
Expression of SLC transporters in Chronic Lymphocytic Leukaemia cells and their interaction with cytostatics
(2009-11-18)Chronic Lymphocytic Leukaemia, CLL, is one of the most common forms of leukaemia in the elderly. The treatment regimen determines the outcome of patients with CLL and the efficiency of this treatment is modulated by the ... -
Filtered spaced-word matches: a novel approach to fast and accurate sequence comparison
(2019-01-22)Standard methods for biological sequence comparison and phylogeny reconstruction are traditionally based on sequence alignments. These methods are very accurate but also computationally expensive. Because of the exponentially ... -
Functional Characterisation of Syndecan, a heparan sulpahte proteoglycan, in Slit/Robo signalling
(2008-04-25)Syndecan (Sdc) is a type I transmembrane protein characterized by the presence of linear sugar chains called heparan sulphate glycosaminoglycans (HSGAGs) linked to its extracellular domain. Sdc was shown to be critical for ... -
Functional Characterization of Hereditary Spastic Paraplegia Proteins Spastin and ZFYVE27
(2010-04-20)Hereditary spastic paraplegias (HSP) are a heterogeneous group of genetic disorders characterized by progressive spasticity in the lower limbs caused primarily due to dysfunction of ... -
Functional conservation of germ plasm organizers Bucky ball in zebrafish and Drosophila Oskar
(2018-12-12)The reproductive cells of many animals are specified by a maternal determinant termed germ plasm. Cells inheriting germ plasm during embryogenesis will develop into primordial germ cells (PGCs), the precursors to eggs and ... -
Functions of Vti1a and Vti1b in the Development of the Mouse Nervous System: Evidence from Double Knockout Mice
(2009-02-12)In eukaryotic cells molecules need to be transported to their correct intracellular destination without compromising the structural integrity of cellular compartments in order to maintain homoeostasis and to allow appropriate ... -
Fundamental Efforts to Develop Novel Biotechnological Approaches in Pest Management Applications against Coleoptera: Transcriptomic Exploration of the Chemical Defense Mechanism in the Red Flour Beetle, Tribolium castaneum
(2013-04-24)Chemical defense is one of the most important traits, which endow insects with the ability to conquer diverse ecological environments. Chemical secretions are used for defense against anything from vertebrate or invertebrate ... -
Die Funktion der inflammatorischen CCR2+ Monozyten bei der postnatalen Mikrogliaentwicklung und bakteriellen Meningitis
(2008-02-12)The central nervous system (CNS) differs from other organs in its privileged status in relation to the immune system. To ensure a specific and stable neuronal environment, the blood-brain barrier separates it from the ... -
Gene prediction in metagenomic sequencing reads
(2009-11-13)Gene prediction is an essential step in the annotation of metagenomic sequencing reads. Since most metagenomic reads cannot be assembled into long contigs, specialized gene prediction tools are required for the analysis ... -
Genomics and Phylogeny of Motor Proteins: Tools and Analyses
(2008-02-19)This work is a collection of several projects that are mainly concerned with the genomics and the phylogeny of Myosins. Two database driven web applications are described. The first, CyMoBase (www.cymobase.org) ... -
Growth, fruiting body development and laccase production of selected coprini
(2008-11-26)The coprini are a form group of mushrooms that grow mainly on compost and horse dung and that for over 100 years were thought to present one genus. Only in 2001 it was discovered by Redhead and coworkers by molecular ... -
Identifizierung und Charakterisierung extrazellulärer Proteine unter dem Einfluss von Verticillium longisporum in Arabidopsis thaliana und Raps (<i>Brassica napus</i>)
(2008-03-04)Verticillium species are soil-borne, xylem-colonizing fungi with worldwide distribution in temperate and subtropical regions. They cause vascular disease in many agriculturally important crops. Verticillium longisporum ... -
Inducing neuroplasticity in the human motor system by transcranial magnetic stimulation: from pathophysiology to a therapeutic option in movement disorders
(2010-05-17)Transcranial magnetic stimulation (TMS) has become a well established method to non-invasively assess corticospinal excitability in human subjects. In addition repetitive transcranial magnetic stimulation (rTMS) is capable ...