GZMB - Göttinger Zentrum für molekulare Biowissenschaften
Recent Submissions
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Metabolism of NHP and SA
(2023-01-02)When mobile organisms face a threat, they have the options of a fight or flight as reaction. The sessile nature of plants narrows their response option down to defend themselves against the threat. Therefore, plants developed ... -
Assembly pathway of the fungal COP9 signalosome
(2022-12-20)The conserved eight-subunit COP9 signalosome (CSN complex) controls the exchange of E3 ubiquitin cullin RING ligase receptors, and therefore the specificity of protein degradation in eukaryotic cells and it is required ... -
Prevention and treatment: Effects on pathological alterations in transgenic Alzheimer’s disease mouse models
(2021-06-21)Alzheimer’s disease (AD) is a neurodegenerative disorder representing the most common form of dementia worldwide. To date, no successful therapeutic approach to treat AD has been developed, hence preventive strategies ... -
Characterization of Mitochondrial Calcium Uniporter in Barth Syndrome Models
(2020-07-15)The Barth Syndrome (BTHS) is caused by the loss of the mitochondrial acyltransferase tafazzin, which is involved in the remodeling process of the hallmark mitochondrial glycerophospholipid cardiolipin. Cardiolipin maintains ... -
Molecular architecture of SF3B and the structural basis of splicing modulation
(2019-06-20)During splicing non-coding introns are excised from the transcribed pre-messenger RNA (pre-mRNA), and the protein-coding exons are ligated to generate the mature mRNA. In cells, the pre-mRNA splicing reaction is catalyzed ... -
Charakterisierung klinisch-relevanter Bakterien mittels Proteotypisierung
(2019-05-03)In case of a disease outbreak fast and reliable detection of the source of infection is crucial. For this reason, typing of microbial species, also at the below-species level is an important task of clinical microbiological ... -
Filtered spaced-word matches: a novel approach to fast and accurate sequence comparison
(2019-01-22)Standard methods for biological sequence comparison and phylogeny reconstruction are traditionally based on sequence alignments. These methods are very accurate but also computationally expensive. Because of the exponentially ... -
Functional conservation of germ plasm organizers Bucky ball in zebrafish and Drosophila Oskar
(2018-12-12)The reproductive cells of many animals are specified by a maternal determinant termed germ plasm. Cells inheriting germ plasm during embryogenesis will develop into primordial germ cells (PGCs), the precursors to eggs and ... -
Chromatin affinity purification coupled with mass spectrometry indetifies novel histone ubiquitylation interactors
(2018-07-12)Histone ubiquitylation is the post-translational covalent attachment of ubiquitin to histones. Ubiquitylation of histones regulates chromatin-templated processes through a combination of structural and functional effects. ... -
Investigation of cpeb1 transcript regulation and potential functions of CPEB1 in germline development in X. laevis
(2017-11-17)Germline specification represents the first functional segregation between two cell populations in the embryo. The germ cell lineage is the source of genetic variation and is essential for the continuity of the species. ... -
The signal transduction of synapse formation and it's failure in Rett syndrome
(2017-04-26)The mechanistic target of rapamycin (mTOR) perceives and integrates various extracellular and intracellular signals and regulates cellular growth and homeostasis. The evolutionary conserved serine/threonine kinase can form ... -
Characterization of Lipoxygenases from Cyanothece sp.
(2016-12-12)Lipoxygenases (LOXs) are non-heme iron- or manganese-containing dioxygenases that catalyze the regio- and stereospecific peroxidation of polyunsaturated fatty acids containing at least one cis,cis-1,4-pentadiene system. ... -
A functional analysis of a signaling center of the insect head
(2014-08-06)Most of our knowledge on embryonic development comes from the fruit y Drosophila melanogaster. An elaborate genetic model explains the segmentation process in the trunk. However, the anterior head region is patterned ... -
Fundamental Efforts to Develop Novel Biotechnological Approaches in Pest Management Applications against Coleoptera: Transcriptomic Exploration of the Chemical Defense Mechanism in the Red Flour Beetle, Tribolium castaneum
(2013-04-24)Chemical defense is one of the most important traits, which endow insects with the ability to conquer diverse ecological environments. Chemical secretions are used for defense against anything from vertebrate or invertebrate ... -
Untersuchungen zur Wirksamkeit von Dacarbazin und Temozolomid bei der Behandlung des kutanen Melanoms in Assoziation mit DNA-Reparatur
(2010-02-09)The aim of this study was to identify individual host markers for hematologic side effects and treatment efficacy of dacarbazine or temozolomide in melanoma treatment. Such markers could facilitate the decision for or ... -
The role of Lissencephaly-1 protein in male germ cell differentiation
(2009-07-24)In the present study the function of Lissencephaly-1 protein in male germ cell differentiation was analysed. A gene trap mouse model (L39) in which a gene trap vector had integrated in intron 2 of Lis1 gene resulted in ... -
Functions of Vti1a and Vti1b in the Development of the Mouse Nervous System: Evidence from Double Knockout Mice
(2009-02-12)In eukaryotic cells molecules need to be transported to their correct intracellular destination without compromising the structural integrity of cellular compartments in order to maintain homoeostasis and to allow appropriate ... -
Growth, fruiting body development and laccase production of selected coprini
(2008-11-26)The coprini are a form group of mushrooms that grow mainly on compost and horse dung and that for over 100 years were thought to present one genus. Only in 2001 it was discovered by Redhead and coworkers by molecular ... -
Patched-assoziierte Tumoren: Modifikatorgene und Pathogenese
(2008-06-05)Patched (Ptch), a component of the Hedgehog (Hh)/Ptch signalling cascade, is frequently mutated in basal cell carcinoma (BCC), medulloblastoma (MB) and rhabdomyosarcoma (RMS). Ptchneo67/+ mice, in which exons 6 and 7 are ... -
Genomics and Phylogeny of Motor Proteins: Tools and Analyses
(2008-02-19)This work is a collection of several projects that are mainly concerned with the genomics and the phylogeny of Myosins. Two database driven web applications are described. The first, CyMoBase (www.cymobase.org) ...