Dokumente Fakultät für Chemie (inkl. GAUSS) nach Gutachter "Zeeck, Axel Prof. Dr."
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Protein NMR studies of two systems involved in bacterial pathogenicity
(2006-12-04)The present work provides new structural information about bacterial proteins involved in transcription regulation and protein secretion, as well as a contribution to the improvement of ... -
Pseudo-helicale und helicale Primärstrukturen aus spiroanellierten vier- und fünfgliedrigen Ringen: Synthesen und chiroptische Eigenschaften
(2006-01-24)The objective of this dissertation is a comparative study of the chiroptical properties of 1,2-spiroannulated helical hydrocarbons of three-, four- and five- membered rings. Towards this ... -
Reaktionen des Amino-di-<i>tert</i>-butylsilanols
(2003-11-26)In contrast to carbon chemistry in silicon chemistry a kinetic stabilization of compounds with two or three OH or NH2 groups bonded to one silicon atom is possible. The reaction of (Me3C)2Si(OH)Cl with liquid ammonia affords ... -
Reaktionen des Bis(tert-butyl-methyl)ketazins mit Halogensilanen
(2004-10-22)This thesis refers to the synthesis of unknown acyclic und cyclic silylketazines. Reactions of monolithiated bis(tert-butyl-methyl)ketazine with chloro- and fluorosilanes lead to acyclic ... -
Struktur und Biosynthese von Collinolacton aus Streptomyces sp. und Beiträge zum Screening neuer Wirkstoffe
(2006-10-16)The cyclodecatrien collinolactone is a new microbial natural product from Streptomyces sp. Gö 40/10 and represents a hitherto unknown chemical class of substances. The structure elucidation ... -
Struktur und Biosynthese von Spirodionsäure und Kirromycin aus Streptomyces sp.
(2009-04-09)The first project is about the investigation of the biosynthesis of the novel microbial metabolite spirodionic acid and its absolute stereoconfiguration. Within the scope of these biosynthetic ... -
Studien zur Ansamitocin-Biosynthese sowie Sekundärstoffproduktion durch mikrobielle Interaktion
(2009-06-23)This thesis is structured in four separate sections. The main part is about biosynthetic investigations of Ansamitocin, a high-potent antitumor agent belonging to the family of the maytansins. ... -
Synthese und Anwendung eines radioaktiven Photoaffinitätslabels zur Wirkortbestimmung von Naturstoffen sowie Beiträge zur Totalsynthese des Collinolactons
(2009-05-05)Starting form Dibromobenzene, an effective synthesis of a radioactive labeled photoaffinity-probe was realized. By using a double-silylated diaziridine as an intermediate the first direct ... -
Synthese und Untersuchung von Alanyl-PNA Oligomeren und deren Einfluß auf β-Faltblatt Strukturen
(2006-08-01)The activity and properties of proteins mainly depend on the three-dimensional arrangment of their secondary structure elements and their conformation. Conformational changes as well as ... -
Synthetisch interessante Transformationen von Ring-anellierten (E,Z,E)-1,3,5-Hexatrienen
(2004-10-05)Twofold palladium-catalyzed coupling reactions (Heck reactions) of 1,2-dibromocycloalkenes with styrene or acrylates afforded 1,6-diphenyl- and 1,6-dialkoxycarbonyl-substituted ... -
Total Synthesis of Various Hormaomycin Analogues with Modified Amino Acid Residues
(2008-07-28)Hormaomycin 1 and its all-peptide aza-analogue 53 were synthesized in quantities of 39 and 34 mg respectively, using the protocol developed by B. Zlatopolskiy, to have enough material for ... -
Towards a Total Synthesis of Mensacarcin
(2004-12-09)The work in this thesis has been concerned with attempts to develop concise synthetic routes to the natural product mensacarcin, which is a novel polyfunctionalised hexahydroanthracene ... -
Untersuchung der synaptischen Neurotransmitterfreisetzung mit kombiniert elektrophysiologischen und bildgebenden Verfahren
(2006-04-25)Neuronal networks in the brain are comprised of a mixture of excitatory and inhibitory neurons. The excitatory and inhibitory cells play distinct roles in the functional network since the ... -
Untersuchungen zur Biosynthese und Aktivität ausgewählter Plecomakrolide sowie chemisches Screening von Actinomyceten
(2005-06-10)This Ph.D. thesis deals with the isolation and structure elucidation of microbial secondary metabolites and comprises studies of their biosynthesis and biological activity.The first part ... -
Unusual Sesquiterpenes: Gorgonenes and Further Bioactive Secondary Metabolites Derived from Marine and Terrestrial Bacteria.
(2009-03-16)An increasing number of infectious diseases is still not curable as many organisms are showing antibiotic resistance which urges the development of new medicaments to combat them. Natural ... -
Zur Biosynthese des Borrelidins sowie Isolierung und Strukturaufklärung von Sekundärmetaboliten aus marinen und terrestrischen Mikroorganismen
(2007-11-06)The relevance of natural products in pharmacological research is now after a long period again gaining more and more attention. Different aspects of natural product research are covered by ...