Browsing Fakultät für Chemie (inkl. GAUSS) by Advisor & Referee "Diederichsen, Ulf Prof. Dr."
Now showing items 21-40 of 102
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Fatty acid oxidizing enzymes in Lobosphaera incisa
(2018-04-23)Green microalgae are a model in biotechnology because of their capacity to accumulate neutral lipids, as part of a general lipid remodeling mechanism under stress. The species L. incisa is of special interest for its unique ... -
Hybrids of SNARE Transmembrane Domains and Artificial Recognition Motifs as Membrane Fusion Inducing Model Peptides
(2018-03-13)Protein mediated fusion of membranes is a crucial biological process. For instance, SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor) proteins are involved in neuronal exocytosis. However, ... -
Dynamics, Intermolecular Interactions, and Organization of Transmembrane β-Peptides
(2018-02-01)Cellular membranes contain a vast variety of proteins, which are practically required for every vital mechanism, such as selective transportation of ions and organic molecules, cell-cell recognition and signal transduction.[1] ... -
Synthesis of Modified and Labelled Lipids for Analysis of Enzyme Mechanisms and Membrane Interactions
(2017-11-21)Communication is key. The development of language represents a milestone in human evolution history. Long before verbal communication evolved, other, more essential forms of information transfer have arisen. The necessity ... -
Fluorescent Dyes and Quenchers with Rigid Linkers
(2017-03-16)Electronic energy transfer (EET) between chromophores is of fundamental importance for many natural processes and technical applications. However, common models fall short in fully describing the process, especially in ... -
Long-range EPR distance measurements with semi-rigid spin labels at Q-band frequencies
(2017-03-02)Elucidating the structure of biomolecules is essential to understand their function. Pulsed electron double resonance (PELDOR) in conjunction with site-directed spin labelling has become a well-established experiment for ... -
The Siamese-Twin Porphyrin and its Metal Complexes: Platforms for Multi-Electron Redox Chemistry
(2017-02-14)This work comprises a redox-chemical investigation of a pyrazole-containing expanded porphyrin - the so-called Siamese-twin porphyrin. It includes synthetic organic and inorganic work and applies a series of analytical ... -
Ruthenium(II) biscarboxylate-Catalyzed C(sp2)-H and C(sp3)-H Functionalizations by Chelation Assistance
(2016-12-06)Functionalizations of C(sp2)-H and C(sp3)-H bond were achieved by Ruthenium(II) biscarboxylate complexes in an atom- and step-economic fashion. -
Development of Zinc-Finger-Based Artificial Restriction Endonucleases and Fluorescent Peptidyl Metal Sensors
(2016-11-17)Zinc finger proteins are ubiquitous in the cellular environment having an excessive diversity and performing variable tasks. Their outstanding capability to develop a sequence-specific bond to deoxyribonucleic acid (DNA) ... -
Organisation and Recognition of Artificial Transmembrane Peptides
(2016-11-15)A various number of cellular key functions such as signalling and transport are mediated by membrane proteins, which are either adhesively bound to the membrane surface or exhibit transmembrane domains. Many transmembrane ... -
Bioinspired Activation of Oxygen with Pyrazole-Supported Dinuclear Copper Complexes
(2016-10-10)A series of compartmental pyrazole-bridging ligands were successfully used to gain insights into copper-mediated dioxygen activation chemistry, and thus expand on the proven potential of these organic scaffolds for emulating ... -
Untersuchungen zur enantioselektiven Totalsynthese von Parnafungin C
(2016-10-10)Within this thesis, two fragments of the natural product Parnafungin C, a highly functionalized chiral chromane with the correct absolute and relative configuration of all stereogenic centers as well as a biaryl system ... -
Quantitative analysis of protein-protein interactions governing TASK-1/TASK-3 intracellular transport
(2016-07-27)The transport of the K+-channels TASK-1 and TASK-3 to the cell surface is regulated by protein-protein interactions with either the COPI vesicle coat, or members of the phosphoadaptor protein family 14-3-3. Interactions ... -
C<sub>2</sub>-Symmetric Pyrazole-Bridged Ligands and Their Application in Asymmetric Transition-Metal Catalysis
(2016-06-03)Within the scope of this thesis the synthesis of a plethora of examples of in total three types of C2-symmetric pyrazole-bridged ligand systems (namely PyrBOX, PyrBPyBOX and ProPyrazole) could be established ... -
Metal containing peptides as specific DNA binders
(2016-01-29)This doctoral thesis involves design and synthesis of small model peptides based on appended domains of DNA binding proteins that are found to be crucial in generating a particular cellular response or function. The model ... -
Zugang zu Agrar- & Pharmawirkstoffen durch organische Synthese
(2015-07-30)This thesis contains the design of new spinosyn analogues via two subsequent heck reactions as well as the modification of a beta-selective glycoslylation method and the synthesis of six new potential Hsp47 inhibitors based ... -
Fluorescence based studies on neuronal processes
(2015-07-22)Synaptotagmin-1 is a calcium dependent trigger of the SNARE-fusion machinery that ultimately upon stimulation executes signal transmission between neurons. However, the actual mechanistic function and the role of ... -
Synthesis and Investigation of Nucleobase Functionalized β-Peptide as SNAREs Model System for Membranefusion
(2015-07-22)In this work, the novel simplified SNARE-mimicking systems consisting of TMD/linker segments of the natural membrane-bound SNARE proteins (syntaxin-1A and synaptobrevin 2) with a nucleobase functionalized β-peptide (β-PNA) ... -
Synthesis of fluorescent toxin and nucleotide derivatives to specifically address membrane proteins
(2015-07-15)Within this project, new tools for in vivo/in vitro labelling were developed and investigated, which may be utilized in the future to elucidate structures, localisation and distinct processes of biomolecules in their native ... -
Post-Synthetic DNA-Functionalization Based on DNA-Templated Dynamic Chemistry
(2015-06-26)With the growing field of DNA technology there is an increasing demand for new modifications of DNA, which improve its versatility and promote the DNA as a fundamental scaffold for a wide field of applications like catalysis, ...