Browsing Fakultät für Chemie (inkl. GAUSS) by Advisor & Referee "Bennati, Marina Prof. Dr."
Now showing items 1-12 of 12
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NMR Spectroscopy of Biomolecular Liquid-Liquid Phase Separation
(2024-02-09)Phase separation of biomolecules has transformed our understanding of cell organization and function, motivating intensive research in the last decade. New evidence for their critical role in mechanisms essential for ... -
Metal-induced aggregation of ß-peptides on membrane surfaces
(2022-04-05)According to the liquid mosaic model of Singer and Nicolson, the cell membrane defines the boundaries of a cell to the inside and outside and describes a twodimensional lipid bilayer. Integrated into this lipid bilayer ... -
Synthesis of new, rigid and conformation stabilizing spin labels for analysis of the orientation of transmembrane domains
(2021-11-15)Lipid-peptide interactions are involved in many essential processes of living organisms, such as cell fusion or transport processes and are therefore, in the center of research interest. One efficient technique to analyze ... -
Investigation of Peptidic Templates for Bioorthogonal Ligations
(2021-08-16)One of the biggest challenges for biochemical researchers in the postgenomic era remains the elucidation of structure-activity relationships in proteins. While many proteins can be routinely produced by recombinant protein ... -
Design and synthesis of small organic molecules to stabilize ALS-associated SOD1 mutants
(2021-06-25)Amyotrophic Lateral Sclerosis is a globally occurring neurodegenerative disease with serious implications for the patient’s life as well as imposing a heavy economic burden both on the affected individuals and society. Due ... -
Revealing atomic resolution structural insights into membrane proteins in near-native environments by proton detected solid-state NMR
(2021-05-18)Membrane proteins are an essential part of any living organism. They are cellular switches that trigger metabolic cascades regulating the cell metabolism, including cell division, gene expression and others functions as ... -
Iron-Catalyzed C–H/N–H Activations for Annulation of Allenes, Alkynes, and Bicyclopropylidenes
(2020-11-16)Iron-catalyzed C–H/N–H activations for the annulation of allenes, alkynes, and bicyclopropylidenes were realized by using a customizable clickable triazole amide under mild reaction conditions. The powerful iron catalysis ... -
Synthesis of Rigid Spin Labels for the Investigation of Transmembrane Peptides by EPR Spectroscopy
(2018-04-27)Transmembrane model peptides enable the investigation of complex protein-lipid interactions since the specific structure of proteins is influenced by the lipid environment. Herein, the synthesis of nitroxide spin labels ... -
Long-range EPR distance measurements with semi-rigid spin labels at Q-band frequencies
(2017-03-02)Elucidating the structure of biomolecules is essential to understand their function. Pulsed electron double resonance (PELDOR) in conjunction with site-directed spin labelling has become a well-established experiment for ... -
Hydrogen Bonds and Electrostatic Environment of Radical Intermediates in Ribonucleotide Reductase Ia
(2016-06-16)Ribonucleotide reductase connects the RNA and the DNA world via strictly controlled radical chemistry that reduces all four essential ribonucleotides to deoxyribonucleotides. In RNR Ia, the starting point is the µ-oxo ... -
Thermal coefficients of methyl groups within ubiquitin and metabolic coupling of NAA and lactate in cortical neurons
(2013-10-30)Protein folding and molecular recognition are physiological processes that are intricately linked to their dynamic signature and reflected in their thermal coefficients. Additionally, the local conformational entropy is ... -
High-field EPR and ENDOR spectroscopy for proton-coupled electron transfer investigations in E.coli ribonucleotide reductase
(2012-02-27)Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides in all organisms, thereby providing the essential precursors for DNA synthesis and replication. ...